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ClinicalTrials.gov public records Last synced Oct 15, 2026, 8:40 PM EDT

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Showing 457–480 of 972 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: marcaine bupivacaine Clear all
Withdrawn Phase 4 Interventional

Bupivacaine Liposomal Injectable Suspension, Pain and Narcotic Use After Elective Orthognathic Surgery

NCT03318757
View directory record Official record
Conditions
Orthognathic Surgery
Interventions
Bupivacaine Extended Release Liposome Injection, Bupivacaine HCl
Drug
Lead sponsor
Boston University
Other
Eligibility
18 Years to 40 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 11, 2020 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Phase 4 Interventional Results available

Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy

NCT03250507
View directory record Official record
Conditions
Hysterectomy
Interventions
Bupivacaine, Liposomal bupivacaine, Saline
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Phase 4 Interventional Results available

A Randomized Trial of Exparel vs Saline in Opioid Reduction of Pain Management Following Lumbar Spine Surgeries.

NCT04644796
View directory record Official record
Conditions
Lumbar Spine Degeneration
Interventions
saline 0.9%, Liposomal bupivacaine
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 13, 2023 · Synced Oct 15, 2026, 8:40 PM EDT
Not listed Phase 1Phase 2 Interventional

Postoperative Pain Control With Lipossomic Extended Release Bupivacaine

NCT03560362
View directory record Official record
Conditions
Pain, Postoperative, Lung Cancer
Interventions
Bupivacaine liposome, Bupivacaine / Epinephrine
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 20, 2018 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Phase I Safety and Immunogenicity Trial of the Facilitated HIV-1 Gag-Pol DNA Vaccine (APL-400-047, Apollon, Inc.) Given Intramuscularly by Needle and Syringe or Biojector 2000 Needle-Free Jet Injection System in HIV-1 Uninfected Adult Volunteers

NCT00001088
View directory record Official record
Conditions
HIV Infections
Interventions
APL 400-047, Bupivacaine hydrochloride
Biological · Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2001
U.S. locations
4
States / cities
Birmingham, Alabama • Rochester, New York • Nashville, Tennessee + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 29, 2008 · Synced Oct 15, 2026, 8:40 PM EDT
Terminated Early Phase 1 Interventional

Multimodal Pain Management Following Primary TKA

NCT02369523
View directory record Official record
Conditions
Pain
Interventions
Exparel, Ropivacaine cocktail (PIC), Bupivacaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Not applicable Interventional

ED50 and ED95 of Isobaric Bupivacaine for Post-Partum Bilateral Tubal Ligation

NCT03779568
View directory record Official record
Conditions
Anesthesia, Local
Interventions
Dose adjustment of bupivacaine
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 19, 2020 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Phase 2 Interventional

Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction

NCT00001724
View directory record Official record
Conditions
Pain
Interventions
Flurbiprofen
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 15, 2026, 8:40 PM EDT
Terminated Not applicable Interventional

Epidural Technique: Does it Really Matter to the Patient?

NCT03539796
View directory record Official record
Conditions
Anesthesia
Interventions
Dural puncture epidurals (DPE), Traditional epidurals (EPI), Combined-spinal epidural technique (CSE)
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 12, 2023 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Phase 4 Interventional Results available

Genicular Nerve Block for Total Knee Arthroplasty

NCT03706313
View directory record Official record
Conditions
Post-operative Pain
Interventions
15mL 0.25% bupivacaine, Genicular nerve block, Saline
Drug · Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Not applicable Interventional

Synovial Fluid Analysis of Intraarticular Elbow Fracture

NCT02878941
View directory record Official record
Conditions
Elbow Fracture, Joint Contracture
Interventions
Synovial Fluid Analysis
Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Not applicable Interventional Results available

Dose Response Study of Dexamethasone in Combination With Bupivacaine 0.25%

NCT01690663
View directory record Official record
Conditions
Post Surgical Pain
Interventions
Bupivacaine 0.25%, Dexamethasone, normal saline
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 4, 2017 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Not applicable Interventional Results available

Continuous Subpleural Infusion of Bupivacaine

NCT01566838
View directory record Official record
Conditions
Postoperative Pain
Interventions
Subpleural pain catheter with infusion of 0.125% bupivacaine, Standard acute pain management
Drug
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 20, 2017 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Not applicable Interventional

Use of Platelet Rich Plasma Therapy for Acute Ankle Sprains in the Emergency Department

NCT01518335
View directory record Official record
Conditions
Sprain of Ankle
Interventions
Platelet rich plasma injection, Placebo Comparator: Placebo/Standard of Care
Procedure
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Infrapatellar Nerve Block for Post-operative Knee Arthroscopy Pain Control

NCT01279447
View directory record Official record
Conditions
Internal Derangement of Knee
Interventions
0.25% Bupivacaine, Normal Saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 12, 2014 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine After Arthroscopic Rotator Cuff Repair

NCT03149887
View directory record Official record
Conditions
Rotator Cuff Tear
Interventions
Liposomal bupivacaine, Placebo
Drug
Lead sponsor
Steven Orebaugh
Other
Eligibility
18 Years to 65 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2020 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Not applicable Interventional Results available

Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty

NCT01333943
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Study Group: Experimental, Control Group
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 90 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Phase 4 Interventional Results available

A Health Economic Trial in Adult Patients Undergoing Ileostomy Reversal MA402S23B501

NCT01509638
View directory record Official record
Conditions
Retraction of Colostomy
Interventions
Group 1 Standard of Care, Group 2 EXPAREL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
2
States / cities
Weston, Florida • Beachwood, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 6, 2014 · Synced Oct 15, 2026, 8:40 PM EDT
Enrolling by invitation Phase 4 Interventional

Liposomal Bupivacaine Versus Continuous Peripheral Nerve Blocks for Analgesia Following Ankle Surgery

NCT06995352
View directory record Official record
Conditions
Moderate-to-severely Painful Ankle Surgery
Interventions
Popliteal nerve block including liposomal bupivacaine, Adductor canal nerve block including liposomal bupivacaine, Continuous popliteal nerve block with normal saline, Popliteal nerve block with exclusively unencapsulated bupivacaine, Adductor canal nerve block with exclusively unencapsulated bupivacaine, Continuous popliteal nerve block with unencapsulated bupivacaine
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 15, 2026, 8:40 PM EDT
Terminated Not applicable Interventional Results available

The Effect of Dexamethasone on the Duration of Interscalene Nerve Blocks With Ropivacaine or Bupivacaine

NCT00801138
View directory record Official record
Conditions
Anesthesia, Local, Shoulder Surgery
Interventions
saline, Dexamethasone, ropivacaine, Bupivacaine
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 1, 2017 · Synced Oct 15, 2026, 8:40 PM EDT
Terminated Phase 4 Interventional Results available

Paravertebral Nerve Blocks in Neonates

NCT03408340
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Paravertebral Nerve Block, Standard of Care Anesthesia
Procedure · Drug
Lead sponsor
Emory University
Other
Eligibility
Up to 12 Months
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Phase 4 Interventional

Bupivacaine Versus Lidocaine on Inflammatory Regulation

NCT01060774
View directory record Official record
Conditions
Pain
Interventions
Lidocaine, Bupivacaine
Drug
Lead sponsor
University of Maryland
Other
Eligibility
18 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Does the Addition of Epinephrine Prolong the Duration of Spinal Anesthesia for Repeat Cesarean Section?

NCT02369510
View directory record Official record
Conditions
Spinal Anesthesia, Cesarean Section
Interventions
Low-dose epinephrine, High-dose epinephrine, No epinephrine
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Oct 15, 2026, 8:40 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty

NCT01683071
View directory record Official record
Conditions
Postoperative Pain
Interventions
Placebo, EXPAREL 67 mg, EXPAREL 133 mg, EXPAREL 266 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
297 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
30
States / cities
Birmingham, Alabama • Mobile, Alabama • Sheffield, Alabama + 23 more
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Oct 15, 2026, 8:40 PM EDT