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Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: nCPAP Clear all
Completed No phase listed Observational

Observational Crossover Study Comparing Oxygenation and Ventilation Using SiPAP Versus CPAP in LBW Infants

NCT01053455
View directory record Official record
Conditions
Ventilation, Respiratory Distress Syndrome
Interventions
SiPAP
Device
Lead sponsor
Children's Hospitals and Clinics of Minnesota
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 21, 2012 · Synced Sep 3, 2026, 8:18 AM EDT
Completed No phase listed Observational

3D Imaging of Neonatal Faces

NCT02603796
View directory record Official record
Conditions
Nose Deformities, Acquired
Interventions
3D Scan of nares
Other
Lead sponsor
Sharp HealthCare
Other
Eligibility
24 Weeks to 42 Weeks
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2016 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Not applicable Interventional Results available

Laryngeal Mask Airway (LMA) for Surfactant Administration in Neonates

NCT01116921
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
Nasal continuous positive airway pressure (nCPAP), Laryngeal Mask Airway (LMA) to deliver surfactant, Surfactants, Pulmonary
Device · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
Up to 36 Hours
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
7
States / cities
Loma Linda, California • San Diego, California • Maple Grove, Minnesota + 4 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2017 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure

NCT01531465
View directory record Official record
Conditions
Respiratory Insufficiency
Interventions
Pulmonary Function Testing & esophageal pressure monitoring, Pulmonary function testing and esophageal pressure
Other
Lead sponsor
Christiana Care Health Services
Other
Eligibility
2 Days to 6 Months
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jun 3, 2013 · Synced Sep 3, 2026, 8:18 AM EDT
Withdrawn Not applicable Interventional

Oscillatory Versus Non-oscillatory Nasal Continuous Airway Pressure Neonatal Respiratory Support

NCT03711565
View directory record Official record
Conditions
Neonatal Respiratory Distress Related Conditions
Interventions
Regular Nasal CPAP using a conventional ventilator, High Frequency Nasal CPAP
Device
Lead sponsor
University of California, Davis
Other
Eligibility
Up to 4 Months
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 5, 2021 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Phase 3 Interventional

Humidified High Flow Nasal Cannula as Compared to Nasal Continuous Positive Airway Pressure

NCT00356668
View directory record Official record
Conditions
Respiratory Distress Syndrome, Cronic Lung Disease
Interventions
High Flow Nasal Cannula
Device
Lead sponsor
Children's Hospitals and Clinics of Minnesota
Other
Eligibility
72 Hours and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 13, 2015 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Phase 2 Interventional Results available

The Safety and Efficacy of Lucinactant for Inhalation in Premature Neonates 26 to 32 Weeks Gestational Age

NCT02636868
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
Lucinactant delivered via investigational delivery device, nCPAP
Drug
Lead sponsor
Windtree Therapeutics
Industry
Eligibility
26 Weeks to 32 Weeks
Enrollment
221 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
22
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Loma Linda, California + 18 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2021 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Phase 3 Interventional

Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)

NCT00433212
View directory record Official record
Conditions
Respiratory Insufficiency of Prematurity
Interventions
nCPAP, NIPPV
Device
Lead sponsor
McMaster University
Other
Eligibility
Up to 28 Days
Enrollment
1,011 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
14
States / cities
Washington D.C., District of Columbia • Boston, Massachusetts • Voorhees Township, New Jersey + 6 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2014 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Not applicable Interventional Results available

Physiological Changes With High-Flow Nasal Cannula

NCT03700606
View directory record Official record
Conditions
Respiratory Distress Syndrome in Premature Infant
Interventions
High flow nasal cannula, Nasal CPAP
Procedure
Lead sponsor
Sharp HealthCare
Other
Eligibility
23 Weeks to 28 Weeks
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 3, 2026, 8:18 AM EDT
Terminated Phase 2 Interventional Results available

Trial To Assess The Safety And Tolerability Of Lucinactant For Inhalation In Preterm Neonates 26 to 28 Weeks PMA

NCT02528318
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
Lucinactant for inhalation, nCPAP alone
Combination Product · Device
Lead sponsor
Windtree Therapeutics
Industry
Eligibility
26 Weeks to 28 Weeks
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
10
States / cities
Loma Linda, California • San Diego, California • Newark, Delaware + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Phase 2 Interventional Results available

Trial to Assess the Safety and Tolerability of Lucinactant for Inhalation in Premature Neonates

NCT02074059
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
Lucinactant for Inhalation, nCPAP alone
Drug · Device
Lead sponsor
Windtree Therapeutics
Industry
Eligibility
29 Weeks to 34 Weeks
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
11
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Loma Linda, California + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Phase 3 Interventional Results available

Delivery Room Management Trial of Premature Infants at High Risk of Respiratory Distress Syndrome

NCT00244101
View directory record Official record
Conditions
Respiratory Distress Syndrome, Newborn
Interventions
PS Group, NCPAP Group, ISX Group
Drug · Device
Lead sponsor
Vermont Oxford Network
Network
Eligibility
26 Weeks to 29 Weeks
Enrollment
648 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2011
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jan 17, 2023 · Synced Sep 3, 2026, 8:18 AM EDT
Withdrawn Not applicable Interventional

Non-Inferiority Trial of Acute HFT Versus nCPAP

NCT01860560
View directory record Official record
Conditions
Mild-Moderate Obstructive Sleep Disordered Breathing
Interventions
High-Flow Therapy, Continuous Positive Airway Pressure
Device
Lead sponsor
Vapotherm, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Glen Burnie, Maryland
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Sep 3, 2026, 8:18 AM EDT
Terminated Not applicable Interventional Results available

High Flow Nasal Cannula Versus Bubble Nasal CPAP for the Treatment of Transient Tachypnea of the Newborn in Infants ≥ 35 Weeks Gestation

NCT01270581
View directory record Official record
Conditions
Transient Tachypnea of the Newborn
Interventions
High Flow Nasal Cannula, Bubble Nasal CPAP
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
Up to 24 Hours
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 15, 2017 · Synced Sep 3, 2026, 8:18 AM EDT
Recruiting Not applicable Interventional

How Different Levels of CPAP Affect Oxygen Delivery and Lung Expansion in Preterm Infants

NCT07674953
View directory record Official record
Conditions
Respiratory Distress Syndrome (Neonatal), Respiratory Distress of Newborn
Interventions
Effective oxygen delivery and lung expansion measurement
Device
Lead sponsor
University of Arkansas
Other
Eligibility
Not listed
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 3, 2026, 8:18 AM EDT
Withdrawn Not applicable Interventional

Oscillatory Versus Non-Oscillatory Nasal Continuous Airway Pressure Neonatal Respiratory Support

NCT01277874
View directory record Official record
Conditions
Respiratory Distress Syndrome, Prematurity
Interventions
Nasal CPAP, Oscillatory NCPAP
Device
Lead sponsor
University of Utah
Other
Eligibility
Up to 28 Days
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
3
States / cities
Madera, California • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Not applicable Interventional

Comparing Weaning of Nasal Continuous Positive Airway Pressure (CPAP) From Preterm Infants

NCT02126501
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
Gradual pressure wean
Other
Lead sponsor
Maimonides Medical Center
Other
Eligibility
26 Weeks to 32 Weeks
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jun 7, 2016 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Not applicable Interventional

High Flow Nasal Cannula in Comparison With Nasal Continuous Positive Airway Pressure in the Management of Respiratory Distress Syndrome

NCT02587832
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
HHHFNC, NCPAP
Device
Lead sponsor
Sidra Medicine
Other
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 26, 2015 · Synced Sep 3, 2026, 8:18 AM EDT
Terminated Phase 2 Interventional Results available

Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants

NCT00807235
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
Aerosolized lucinactant
Drug
Lead sponsor
Windtree Therapeutics
Industry
Eligibility
15 Minutes to 30 Minutes
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 12, 2012 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Not applicable Interventional

Determining an Optimal Weaning Method of Nasal Continuous Positive Airway Pressure in Preterm Neonates

NCT02064712
View directory record Official record
Conditions
Infant, Newborn, Infant, Premature
Interventions
Low CPAP Wean, High CPAP Wean
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
Up to 32 Weeks
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 21, 2018 · Synced Sep 3, 2026, 8:18 AM EDT
Recruiting Phase 3 Interventional

Safety and Efficacy of APC-0101 in Preterm Infants With Respiratory Distress Syndrome

NCT06776783
View directory record Official record
Conditions
Respiratory Distress Syndrome, Pre-term Infants
Interventions
APC-0101 (SF-RI 1 surfactant for inhalation combined with a dedicated delivery system), Control
Combination Product · Other
Lead sponsor
Aerogen Pharma Limited
Industry
Eligibility
1 Hour to 24 Hours
Enrollment
520 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
12
States / cities
Little Rock, Arkansas • La Jolla, California • Jacksonville, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 3, 2026, 8:18 AM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP

NCT01939067
View directory record Official record
Conditions
Respiratory Distress, Lung Injury
Interventions
Heated Humidified High Flow Nasal Cannula, Nasal Continuous Positive Airway Pressure
Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
2 Hours to 72 Hours
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 14, 2015 · Synced Sep 3, 2026, 8:18 AM EDT
Completed Not applicable Interventional Results available

A Comparison of Non-invasive Ventilation Methods Used to Prevent Endotracheal Intubation Due to Apnea in Very Low Birth Weight Infants

NCT03298035
View directory record Official record
Conditions
Apnea of Prematurity
Interventions
NCPAP as mode for apnea prevention, NIPPV as rescue mode for apnea prevention
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
Not listed
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 6, 2020 · Synced Sep 3, 2026, 8:18 AM EDT
Completed No phase listed Observational

Nasal Continuous Positive Airway Pressure and Airway Patency in Obese Patient

NCT03024723
View directory record Official record
Conditions
Obese
Interventions
nasal mask CPAP
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Sep 3, 2026, 8:18 AM EDT