Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)
Public ClinicalTrials.gov record NCT00433212. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of NIPPV to Increase Survival Without Bronchopulmonary Dysplasia in Extremely Low Birth Weight Infants
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The machines and oxygen used to help very premature babies breathe can have side-effects, such as bronchopulmonary dysplasia (BPD). Infants with BPD get more complications (a higher death rate, a longer time in intensive care and on assisted ventilation, more hospital readmissions in the first year of life, and more learning problems) than infants who do not develop BPD. Doctors try to remove the tube in the wind-pipe that links the baby to the breathing machine as soon as possible. However, small babies get tired, and still require help to breathe. One of the standard and common techniques to help them breathe without a tube in the wind-pipe is to use simple pressure support, nasal continuous positive airway pressure or nCPAP. This supports breathing a little, but it is often not enough to prevent the need to go back on the breathing machine. Nasal intermittent positive pressure ventilation (NIPPV) is similar to nCPAP, but also gives some breaths, or extra support, to babies through a small tube in the nose. NIPPV is safe and effective, and already in use as an alternate "standard" therapy. The main research question: After being weaned from the breathing machine, is NIPPV better than nCPAP in preventing BPD in premature babies weighing 999 grams or less at birth?
Study identification
- NCT ID
- NCT00433212
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,011 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- Up to 28 Days
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 31, 2007
- Primary completion
- Jul 31, 2011
- Completion
- Nov 30, 2011
- Last update posted
- Dec 4, 2014
2007 – 2011
United States locations
- U.S. sites
- 14
- U.S. states
- 6
- U.S. cities
- 9
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Georgetown University Children's Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| The George Washington University Hospital | Washington D.C. | District of Columbia | 20037 | — |
| Tufts University Medical Center | Boston | Massachusetts | 02111 | — |
| Beth Israel Deaconess Medical Center (BIDMC) | Boston | Massachusetts | 02215 | — |
| Virtua West Jersey Hospital | Voorhees Township | New Jersey | 08043 | — |
| SUNY Downstate Medical Center | Brooklyn | New York | 11023 | — |
| Kings County Hospital | Brooklyn | New York | 11203 | — |
| New York Hospital Queens | Brooklyn | New York | 11355 | — |
| Queens Hospital Center | Jamaica | New York | 11432 | — |
| Brookdale University Hospital & Medical Center | New York | New York | 11212 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794-8111 | — |
| Pennsylvania Hospital/U. of Pennsylvania | Philadelphia | Pennsylvania | 19035 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| University of Utah | Salt Lake City | Utah | 84158-1289 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00433212, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 4, 2014 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00433212 live on ClinicalTrials.gov.