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ClinicalTrials.gov public records Last synced Nov 3, 2026, 6:55 AM EST

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Showing 1–24 of 230 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: opioid prescribing Clear all
Not listed Not applicable Interventional

Open Label Placebo to Reduce Prescription Opioid Use

NCT05014230
View directory record Official record
Conditions
Acute Pain
Interventions
Open Placebo, Opioid medication as part of standard care
Dietary Supplement · Other
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Nov 3, 2026, 6:55 AM EST
Completed No phase listed Observational

Postpartum Pain Experience and Attitudes About Opioid Prescribing

NCT05202795
View directory record Official record
Conditions
Postpartum Pain, Pain Management, Opioid Prescribing
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
46 participants
Timeline
2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

A Randomized Trial of Behavioral Economic Approaches to Reduce Unnecessary Opioid Prescribing

NCT03825549
View directory record Official record
Conditions
Acute Pain
Interventions
Individual audit feedback, Peer comparison feedback
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
452 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Walnut Creek, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

De-prescribing Program to Evaluate Falls in Older Adults

NCT04272671
View directory record Official record
Conditions
Opioid-Related Disorders, Benzodiazepine-Related Disorders, Falls Injury
Interventions
Educational Intervention
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
65 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 5, 2022 · Synced Nov 3, 2026, 6:55 AM EST
Not listed Not applicable Interventional

Pharmacogenomics Applied to Chronic Pain Treatment in Primary Care

NCT04685304
View directory record Official record
Conditions
Chronic Pain
Interventions
Pharmacogenetic Testing, Pharmacist Consultation Note, Delayed pharmacogenetic testing
Genetic · Other
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Results available

Collaborating to Heal Addiction and Mental Health in Primary Care

NCT04600414
View directory record Official record
Conditions
Opioid-use Disorder, Mental Health Disorder
Interventions
Collaborative Care for Mental Health Symptoms, Collaborative Care for Opioid Use Disorder and Mental Health Symptoms
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
33
States / cities
Washington D.C., District of Columbia • Atlanta, Georgia • Dunwoody, Georgia + 22 more
Source: ClinicalTrials.gov public record
Updated Oct 3, 2025 · Synced Nov 3, 2026, 6:55 AM EST
Completed No phase listed Observational

Targeting Effective Analgesia in Clinics for HIV - Patient Cohort

NCT02525731
View directory record Official record
Conditions
HIV Infection, Pain, Drug Dependence
Interventions
Not listed
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
Atlanta, Georgia • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

An Opioid Prescribing Nudge

NCT04069403
View directory record Official record
Conditions
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior, Benzodiazepine Abuse, Benzodiazepine Dependent
Interventions
Automated Reports on prescription patterns for their patients
Other
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
427 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 30, 2020 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Results available

Spine Pain INtervention to Enhance Care Quality And Reduce Expenditure

NCT03083886
View directory record Official record
Conditions
Back Pain, Neck Pain
Interventions
Identify, Coordinated, Enhanced (ICE) Decision Making + PCP led care, Individualized Postural Therapy (IPT) + PCP led care, Usual PCP led care
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
3,087 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
8
States / cities
Phoenix, Arizona • Laguna Hills, California • North Hollywood, California + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Nov 3, 2026, 6:55 AM EST
Suspended Phase 4 Interventional

Opioid Reduction Toolkit Reduces Opioids Prescribed and Consumed

NCT05363436
View directory record Official record
Conditions
Opioid Abuse, Opioid Misuse, Pain
Interventions
Oxycodone
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 99 Years
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 22, 2024 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Results available

Employment-based Reinforcement of Naltrexone Ingestion and Abstinence

NCT00149669
View directory record Official record
Conditions
Cocaine-Related Disorders, Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
Interventions
employment-based reinforcement
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 14, 2017 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 2 Interventional Results available

Treating Negative Affect in Low Back Pain Patients

NCT04747314
View directory record Official record
Conditions
Chronic Low Back Pain, Negative Affectivity
Interventions
Antidepressant, Enhanced Fear Avoidance Rehabilitation
Drug · Other
Lead sponsor
Ajay Wasan, MD, Msc
Other
Eligibility
18 Years to 75 Years
Enrollment
308 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Chestnut Hill, Massachusetts • Rochester, Minnesota • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Results available

Strategies for Prescribing Analgesics Comparative Effectiveness Trial

NCT01583985
View directory record Official record
Conditions
Back Pain, Osteoarthritis
Interventions
Opioid-intensive prescribing strategy, Opioid-avoidant prescribing strategy
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
265 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 6, 2019 · Synced Nov 3, 2026, 6:55 AM EST
Completed Early Phase 1 Interventional

Pilot Trial of Microsphere Oxycodone (Xtampza ER) for Pain Management in Patients Receiving Radiotherapy for Locally Advanced Head and Neck Cancer

NCT03317730
View directory record Official record
Conditions
Locally Advanced Head and Neck Cancer
Interventions
Xtampza ER
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 20, 2021 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional

Post-Discharge Opioid Reduction Intervention for Open, Laparoscopic, and Endoscopic Surgery

NCT03536065
View directory record Official record
Conditions
Prostate Cancer, Opioid Use
Interventions
Opioid Reduction Intervention, Current Care
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years · Male only
Enrollment
443 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 3 Interventional Results available

Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdrawal

NCT01863186
View directory record Official record
Conditions
Opioid Dependence, Acute Opioid Withdrawal Syndrome
Interventions
Lofexidine HCl, Placebo, Open Label Lofexidine HCL
Drug
Lead sponsor
USWM, LLC (dba US WorldMeds)
Industry
Eligibility
18 Years and older
Enrollment
603 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
18
States / cities
Clovis, California • Escondido, California • San Diego, California + 15 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2022 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Results available

AESOPS Trial 2 (AESOPS-2): Availability of Opioid Harm

NCT04758637
View directory record Official record
Conditions
Opioid Abuse
Interventions
Overdose Notification
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Controlled Substance Treatment Agreements in an Internal Medicine Residents' Clinic

NCT02244099
View directory record Official record
Conditions
Anxiety, Chronic Pain, Opioid Use, Unspecified
Interventions
Controlled Substance
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 24, 2015 · Synced Nov 3, 2026, 6:55 AM EST
Recruiting Phase 4 Interventional

A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

NCT04375033
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Sublingual buprenorphine with naloxone, Injectable subcutaneous buprenorphine
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
952 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2029
U.S. locations
25
States / cities
Tuscaloosa, Alabama • Phoenix, Arizona • Long Beach, California + 21 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Results available

Testing a Provider-Level Feedback Intervention to Optimize Postoperative Prescribing

NCT04776928
View directory record Official record
Conditions
Opioid Prescribing
Interventions
Push reports
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
217 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Nov 3, 2026, 6:55 AM EST
Terminated Phase 4 Interventional Accepts healthy volunteers

Effect of Gabapentin on Postoperative Opioid Analgesic Use and Pain in Adolescents Undergoing Tonsillectomy

NCT05024825
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Gabapentin, hydrocodone, acetaminophen and ibuprofen
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
12 Years to 18 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2021 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

E-mails to Nudge Safer and Better-Informed Prescribing of Risky Drugs

NCT06443385
View directory record Official record
Conditions
Opioid Prescribing, Prescription Drug Misuse
Interventions
PDMP Legal Mandate E-mail, PDMP Clinical Benefit E-mail
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
7,872 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reducing Prescription Opioid Misuse: ROPEs Pilot Trial

NCT03691948
View directory record Official record
Conditions
Knowledge, Attitudes, Practice
Interventions
Responsible Opioid Prescriber Education (ROPES), Active Comparator Control
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 4 Interventional

A Study Of Opioid Avoidance In Surgery Through Integrating Suzetrigine

NCT07257133
View directory record Official record
Conditions
Post Operative Pain
Interventions
Suzetrigine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Nov 3, 2026, 6:55 AM EST