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ClinicalTrials.gov public records Last synced Oct 19, 2026, 4:51 PM EDT

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Showing 361–384 of 757 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: pain blocking Clear all
Recruiting Phase 1Phase 2 Interventional

Minimally Invasive Esophagectomy Pain Control Trial

NCT05906134
View directory record Official record
Conditions
Postoperative Pain, Acute, Postoperative Complications
Interventions
Local intercostal nerve block, Cryo-analgesia and intercostal nerve block, Serratus plane catheter blocks and intercostal nerve blocks, Thoracic epidural catheter
Procedure
Lead sponsor
Swedish Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Oct 19, 2026, 4:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The CIA Score: a Learner's Tool

NCT05153265
View directory record Official record
Conditions
Anesthesia, Local
Interventions
Survey
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 16, 2022 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Paracervical Versus Intracervical Lidocaine

NCT00816751
View directory record Official record
Conditions
Abortion, Induced, Pain
Interventions
Paracervical block, Intracervical, Buffered Lidocaine, vasopressin, sodium bicarbonate
Procedure · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 13, 2019 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Phase 3 Interventional

Pilot: Intraoperative TAP Block and Post-operative Pain Control for Minimally Invasive Hysterectomy for Endometrial Cancer

NCT05763667
View directory record Official record
Conditions
Post Operative Pain, Gynecologic Cancer
Interventions
Liposomal bupivacaine, Bupivacain
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Oct 19, 2026, 4:51 PM EDT
Recruiting Phase 4 Interventional

The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair

NCT07076069
View directory record Official record
Conditions
Rotator Cuff Repairs, Pain Management
Interventions
Multimodal Pain Regimen, Standard of Care Pain Regimen
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery

NCT02274870
View directory record Official record
Conditions
Post-operative Pain
Interventions
Liposome Bupivacaine, Bupivacaine HCl
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 74 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Valley Stream, New York
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Not applicable Interventional

Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain

NCT02578108
View directory record Official record
Conditions
Osteoarthritis, Knee, Pain, Nerve; Lesion
Interventions
genicular nerve diagnostic block with lidocaine (local anesthetic), genicular nerve radiofrequency ablation
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
30 Years to 80 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 21, 2019 · Synced Oct 19, 2026, 4:51 PM EDT
Recruiting Phase 3 Interventional

Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery

NCT07539623
View directory record Official record
Conditions
Bariatric Surgery, Cardiac Surgery With Sternotomy, Post-operative Pain
Interventions
Suzetrigine, Placebo
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 85 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 19, 2026, 4:51 PM EDT
Terminated Early Phase 1 Interventional

Multimodal Pain Management Following Primary TKA

NCT02369523
View directory record Official record
Conditions
Pain
Interventions
Exparel, Ropivacaine cocktail (PIC), Bupivacaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Phase 4 Interventional Results available

Septorhinoplasty Post-operative Pain Control With SPG Nerve Block

NCT05667324
View directory record Official record
Conditions
Deviated Nasal Septum
Interventions
Ropivacaine, Dexamethasone, Placebo
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 19, 2026, 4:51 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Pain Measured by NRS and EEG in Acute Pulpitis

NCT06526572
View directory record Official record
Conditions
Acute Pulpitis
Interventions
Brain wave analysis using electroencephalography (EEG)., Numerical rate Scale (NRS)
Diagnostic Test
Lead sponsor
Cleveland Dental Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Not applicable Interventional

The Effectiveness of Immersive Virtual Reality as a Pain Control Modality After Hip Arthroscopy

NCT05868369
View directory record Official record
Conditions
Hip Pain Chronic
Interventions
iVR Group, Standard pain management regimen
Device · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Quadratus Lumborum Block Versus Control for Total Hip Arthroplasty

NCT03408483
View directory record Official record
Conditions
Total Hip Arthroplasty
Interventions
Quadratus Lumborum Block (QLB), Standard of Care
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Not applicable Interventional

Exparel and Ankle Surgery

NCT02072135
View directory record Official record
Conditions
Ankle Fracture
Interventions
Exparel
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 23, 2016 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Phase 4 Interventional Results available

Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty

NCT02658149
View directory record Official record
Conditions
Osteoarthritis, Arthroplasty
Interventions
Ropivacaine with NaCl, Epinephrine, Morphine, Ketorolac Tromethamine, Ropivacaine
Drug
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated May 9, 2018 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Self-administered Lidocaine Gel for Pain-control During Cervical Preparation for Dilation and Evacuation

NCT02852434
View directory record Official record
Conditions
Pain Management, Cervical Preparation
Interventions
Lidocaine Gel (2%), Lidocaine Paracervical Block (1%)
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2019 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Auriculotherapy for Surgical Pain

NCT03860259
View directory record Official record
Conditions
Acute Pain, Surgery, Shoulder Pain
Interventions
Auriculotherapy cryopuncture device without nitrogen gas, Auriculotherapy cryopuncture device with nitrogen gas
Device
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 17, 2022 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Phase 3 Interventional Results available

Evaluation of Anterior Quadratus Lumborum Block for Postoperative Analgesia in Hip Arthroscopy

NCT03432650
View directory record Official record
Conditions
Hip Disease
Interventions
Bupivacaine + dexamethasone, Ultrasound
Drug · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2022 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Phase 4 Interventional Results available

Surgeon Infiltration QL Block Comparison

NCT03496610
View directory record Official record
Conditions
Quadratus Lumborum Block, Surgical Wound Infiltration
Interventions
Liposomal Bupivicaine, QL Block
Drug · Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Not applicable Interventional Results available

Ultrasound-Assisted Paravertebral Block v. Traditional Paravertebral Block For Pain Control

NCT01949480
View directory record Official record
Conditions
Paravertebral Peripheral Nerve Block, Acute Pain Management
Interventions
Thoracotomy, Video-Assisted Thoracoscopic Surgery (VATS)
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 75 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 22, 2019 · Synced Oct 19, 2026, 4:51 PM EDT
Active, not recruiting Not applicable Interventional

Effects of Musical Intervention on Patient Pain and Anxiety for Office-based Procedures

NCT06235996
View directory record Official record
Conditions
Chronic Pain
Interventions
Office-based procedure indicated for chronic pain with music, Office-based procedure indicated for chronic pain without music
Procedure
Lead sponsor
Lake Erie College of Osteopathic Medicine
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Wesley Chapel, Florida • Zephyrhills, Florida
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Oct 19, 2026, 4:51 PM EDT
Completed Not applicable Interventional Results available

A Comparison of Postoperative Analgesic Nerve Block Ropivacaine Concentrations

NCT01556724
View directory record Official record
Conditions
Total Hip Arthroplasty, Postoperative Pain
Interventions
0.1% or 0.2% ropivacaine nerve blocks
Drug
Lead sponsor
Sylvia Wilson
Other
Eligibility
18 Years to 75 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Oct 19, 2026, 4:51 PM EDT
Not listed Phase 4 Interventional

ICNBs for Post-op Pain in Breast Surgery

NCT04606836
View directory record Official record
Conditions
Pain, Postoperative, Length of Stay
Interventions
Bupivacaine Hydrochloride
Drug
Lead sponsor
Christine M. Kleinert Institute for Hand and Microsurgery
Other
Eligibility
20 Years to 70 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
5
States / cities
New Albany, Indiana • Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Oct 19, 2026, 4:51 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

A Comparison of the Post-C/S Analgesic Effects of Neuraxial Duramorph vs Bilateral TAP Block With Liposomal Bupivacaine

NCT03638011
View directory record Official record
Conditions
Caesarean Section
Interventions
Exparel
Drug
Lead sponsor
Maimonides Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jun 7, 2022 · Synced Oct 19, 2026, 4:51 PM EDT