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ClinicalTrials.gov public records Last synced Oct 25, 2026, 11:51 PM EDT

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Showing 1–24 of 90 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: propofol general anesthesia Clear all
Completed Not applicable Interventional Results available

Sedation in Patients at Risk for Upper Airway Collapse

NCT01045122
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Propofol, Dexmedetomidine
Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2015 · Synced Oct 25, 2026, 11:51 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Dose-Finding and Human Abuse Potential Study Of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users

NCT05614544
View directory record Official record
Conditions
General Anesthesia
Interventions
HSK3486, Propofol, Placebo
Drug
Lead sponsor
Haisco-USA Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 13, 2023 · Synced Oct 25, 2026, 11:51 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects

NCT01557920
View directory record Official record
Conditions
Airway Complication of Anaesthesia, Healthy
Interventions
Propofol, Sevoflurane
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 13, 2016 · Synced Oct 25, 2026, 11:51 PM EDT
Recruiting Phase 4 Interventional

Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia

NCT07348614
View directory record Official record
Conditions
Knee Stiffness After Total Knee Arthroplasty
Interventions
Spinal Anesthesia, General Anesthesia, Propofol, Chloroprocaine
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 75 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 25, 2026, 11:51 PM EDT
Completed No phase listed Observational

Functional Near Infrared Spectroscopy to Detect Pain in Young Children Under General Anesthesia

NCT04362423
View directory record Official record
Conditions
Pain
Interventions
fNIRS
Device
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
1 Month to 16 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Oct 25, 2026, 11:51 PM EDT
Completed Phase 4 Interventional Results available

Desflurane or Propofol Anesthesia in Elderly Obese Patients Undergoing Total Knee Replacement

NCT01270620
View directory record Official record
Conditions
Obesity, Arthritis
Interventions
propofol, Desflurane
Drug
Lead sponsor
Pedro Paulo Tanaka
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 22, 2015 · Synced Oct 25, 2026, 11:51 PM EDT
Terminated Not applicable Interventional Results available

Infrared Pupillometry During General Anesthesia to Predict Pain

NCT02058511
View directory record Official record
Conditions
Postoperative Pain, Objective Assessment of Sedation
Interventions
Anesthesia Premedication, Induction and Maintenance, Pupillometry after administration of anesthetic drugs
Drug · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 99 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 15, 2019 · Synced Oct 25, 2026, 11:51 PM EDT
Terminated Phase 4 Interventional Results available

Anesthetic Techniques in EP Patients

NCT02664922
View directory record Official record
Conditions
Cardiac Disease
Interventions
Propofol, Ketamine, Remifentanil, Sevoflurane
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2020 · Synced Oct 25, 2026, 11:51 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Rectal Acetaminophen Use During Oocyte Retrievals to Reduce Post-Operative Opioid Utilization

NCT03732469
View directory record Official record
Conditions
Opioid Use
Interventions
Acetaminophen, Fentanyl, Propofol
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 56 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2021 · Synced Oct 25, 2026, 11:51 PM EDT
Completed Phase 3 Interventional

THRIVE Feasibility Trial

NCT05346588
View directory record Official record
Conditions
Surgery--Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia Emergence Delirium, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Nausea, Postoperative, Anesthesia Morbidity, Depression, Sleep Disorders, Circadian Rhythm
Interventions
Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
4
States / cities
Stanford, California • Ann Arbor, Michigan • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2023 · Synced Oct 25, 2026, 11:51 PM EDT
Completed Phase 4 Interventional Results available

Awake Caudal Catheter vs General Anesthesia

NCT05919732
View directory record Official record
Conditions
Inguinal Hernia
Interventions
Bupivacaine, Dexmedetomidine, Caffeine, Tylenol, Propofol, rocuronium, caffeine, Tylenol, bupivacaine
Drug
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
23 Weeks to 60 Weeks
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 25, 2026, 11:51 PM EDT
Terminated Not applicable Interventional Results available

Intravenous Sedation Versus General Anesthesia in Patients Undergoing Minor Gynecologic Surgery

NCT01890707
View directory record Official record
Conditions
Surgery, Anesthesia, Pain
Interventions
General Anesthesia, Deep Sedation
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 2, 2020 · Synced Oct 25, 2026, 11:51 PM EDT
Recruiting Not applicable Interventional

Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils

NCT06258837
View directory record Official record
Conditions
Otolaryngological Disease, Obstructive Sleep Apnea
Interventions
DISE-Directed Surgery, Adenotonsillectomy
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
2 Years to 17 Years
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Ann Arbor, Michigan • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 25, 2026, 11:51 PM EDT
Withdrawn Not applicable Interventional

Intravenous Anesthesia Versus Anesthesia With Volatile Agents in Elective Craniotomy for Tumors

NCT00555984
View directory record Official record
Conditions
Brain Neoplasms
Interventions
Propofol + Remifentanil, Sevoflurane + Remifentanil
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Oct 25, 2026, 11:51 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients

NCT04443517
View directory record Official record
Conditions
Postoperative Delirium
Interventions
Alpha Optimization, Emergence from anesthesia with Dexmedetomidine
Procedure · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
60 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 25, 2026, 11:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparative Effects of Two Anesthetic Techniques on Auditory Brain Response in Children

NCT02830815
View directory record Official record
Conditions
Auditory Brainstem Response
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Up to 18 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 2, 2021 · Synced Oct 25, 2026, 11:51 PM EDT
Terminated Not applicable Interventional

Patient Satisfaction and Postoperative Analgesia Between Subarachnoid Block With 2-chloroprocaine Versus General Anesthesia for Knee Arthroscopy

NCT03173326
View directory record Official record
Conditions
Knee Arthroscopy, General Anesthesia, Subarachnoid Block
Interventions
General anesthesia, Subarachnoid block
Procedure
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
30 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 8, 2018 · Synced Oct 25, 2026, 11:51 PM EDT
Completed Phase 4 Interventional Results available

Effect of Intraoperative Anesthetic Management on Postoperative Nausea and Vomiting in Bariatric Surgery

NCT01449708
View directory record Official record
Conditions
Postoperative Nausea and Vomiting
Interventions
TIVA NoNarc
Drug
Lead sponsor
Coastal Anesthesiology Consultants
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Saint Augustine, Florida
Source: ClinicalTrials.gov public record
Updated Mar 21, 2016 · Synced Oct 25, 2026, 11:51 PM EDT
Enrolling by invitation Phase 3 Interventional Accepts healthy volunteers

GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries

NCT05444751
View directory record Official record
Conditions
Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
Interventions
General anesthetic, SA + ESP
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 25, 2026, 11:51 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Two Anesthetic Techniques in Magnetic Resonance Imaging (MRI)

NCT00894751
View directory record Official record
Conditions
Magnetic Resonance Imaging, Anesthesia
Interventions
dexmedetomidine, propofol
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Months to 7 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Oct 25, 2026, 11:51 PM EDT
Recruiting Not applicable Interventional

BELUGA: Better to Exchange ETT for LMA Before Extubation in Children Under General Anaesthesia

NCT07204990
View directory record Official record
Conditions
Endotracheal Extubation, Airway Anesthesia, Paediatric
Interventions
Direct removal of endotracheal tube, Laryngeal mask airway inserted following deep extubation
Procedure
Lead sponsor
Telethon Kids Institute
Other
Eligibility
0 Years to 16 Years
Enrollment
1,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 25, 2026, 11:51 PM EDT
Completed Not applicable Interventional Results available

Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly

NCT00788008
View directory record Official record
Conditions
Lumbar Spondylosis, Cervical Spondylosis, Hip Osteoarthritis, Knee Osteoarthritis
Interventions
inhalation anesthesia with isoflurane vs. TIVA with propofol
Drug
Lead sponsor
Duke University
Other
Eligibility
65 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 26, 2015 · Synced Oct 25, 2026, 11:51 PM EDT
Withdrawn Phase 4 Interventional

GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture

NCT03226080
View directory record Official record
Conditions
Hip Fractures, Anesthesia, Spinal, Anesthesia, General, Neuromuscular Blockade
Interventions
Rocuronium, Sugammadex, Normal saline
Drug
Lead sponsor
Loyola University
Other
Eligibility
55 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Oct 25, 2026, 11:51 PM EDT
Withdrawn Phase 2 Interventional

Compare the Effect of Propofol vs. "Ketofol" on Hemodynamic Stability During Induction of General Anesthesia

NCT02282891
View directory record Official record
Conditions
Patients With "ASA 3" Designation
Interventions
Propofol, Propofol-Ketamine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 15, 2016 · Synced Oct 25, 2026, 11:51 PM EDT