Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 12, 2026, 4:44 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 213 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: reduced calorie diet Clear all

Conditions: Orthostatic Hypotension, Falls
Interventions: Medication review, Nutrition/Salt intake, Education, Exercise, Drug Recommendations; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 99 Years
Enrollment: 356 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Obesity, Weight Loss, Diet Modification, Aging, Weight Change, Body, Dietary Habits, Osteopenia, Osteoporosis, Bone Loss, Fractures, Bone
Interventions: Weight loss intervention months 0-6, Exercise intervention months 0-6, NutraBio™ CarboMax Supplement, 6-month NutraBio™ 100% Whey Protein Isolate Supplement, 18-month NutraBio™ 100% Whey Protein Isolate Supplement; Behavioral · Dietary Supplement
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 65 Years to 85 Years
Enrollment: 187 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Obesity
Interventions: Dietary substitution A, Dietary Substitution B, Healthy Choices; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 65 Years
Enrollment: 318 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Obesity, Cardiovascular Diseases, Heart Diseases
Interventions: Diet, Exercise, Environment; Behavioral
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Obesity
Interventions: Alternate Day Intermittent Energy Restriction, Reduced Calorie Diet; Other
Lead sponsor: Texas Tech University; Other
Eligibility: 18 Years to 25 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 2
States / cities: Lubbock, Texas

Conditions: Calorie Restriction
Interventions: Not listed
Lead sponsor: Tufts University; Other
Eligibility: 33 Years to 70 Years
Enrollment: 216 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 3
States / cities: Baton Rouge, Louisiana • Boston, Massachusetts • St Louis, Missouri

Conditions: Weight Loss, BMD
Interventions: Weight Loss, Weight Maintenance; Behavioral
Lead sponsor: Rutgers University; Other
Eligibility: 50 Years to 72 Years · Male only
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Obesity
Interventions: Tapered Low Calorie Diet, Traditional Low-Calorie Diet; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 45 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Obesity, Overweight, Diabetes Mellitus, Type 2
Interventions: NNC0487-0111, Semaglutide, Placebo (matched to NNC0487-0111), Placebo (matched to semaglutide); Drug
Lead sponsor: Novo Nordisk A/S; Industry
Eligibility: 18 Years and older
Enrollment: 985 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 10
States / cities: Hollywood, Florida • Orange City, Florida • Weston, Florida + 7 more

Conditions: Advanced Non-small Cell Lung Cancer, EGFR Mutation, HER2 Mutation, Healthy Volunteers
Interventions: BAY2927088, Esomeprazole, Food; Drug · Other
Lead sponsor: Bayer; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Sweetness Liking Adaptation
Interventions: Flavored carbonated soft drink (CSD); Other
Lead sponsor: PepsiCo Global R&D; Industry
Eligibility: 25 Years to 55 Years
Enrollment: 168 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Addison, Illinois

Conditions: Insulin Resistance, Hypertriglyceridemia
Interventions: Rosiglitazone, Fenofibrate, Weight Loss; Drug · Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 30 Years to 65 Years
Enrollment: 47 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2008
U.S. locations: 1
States / cities: Stanford, California

Conditions: Breast Cancer
Interventions: Cognitive behavioral therapy CBT) for weight loss; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 90 Years · Female only
Enrollment: 253 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Obesity, Insulin Resistance, Metabolically Healthy Obesity, Obesity, Metabolically Benign
Interventions: People with Metabolically Unhealthy Obesity - Low Calorie Diet; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 25 Years to 55 Years
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Breast Cancer, Obesity, Weight Changes
Interventions: behavioral dietary intervention, Exercise intervention; Behavioral
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 50 Years to 75 Years · Female only
Enrollment: 439 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
Interventions: Biospecimen Collection, Dual X-ray Absorptiometry, Functional Assessment, Lifestyle Counseling, Semaglutide; Procedure · Other · Behavioral + 1 more
Lead sponsor: Mayo Clinic; Other
Eligibility: 46 Years to 55 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2035
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Diet Modification, Lung Cancer
Interventions: Special Diet Therapy (low-carb), Special Diet Therapy (low-fat), Special Diet Therapy (USDA control); Behavioral
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Type 2 Diabetes Mellitus, Overweight, Obesity
Interventions: Low carbohydrate, ketogenic diet, Low glycemic index, reduced calorie diet; Behavioral
Lead sponsor: Robert C. Atkins Foundation; Other
Eligibility: 18 Years to 65 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Liver Cirrhoses, Portal Hypertension Related to Cirrhosis, Severe Obesity, TIPS
Interventions: Transjugular Intrahepatic Portosystemic Shunt (TIPS), Sleeve Gastrectomy, Anti-Obesity Pharmacotherapy (Class Effect), Lifestyle Counseling - Diet & Physical-Activity Program; Procedure · Drug · Behavioral
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 70 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2034
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Overweight, Obesity, Weight Loss, Health Behavior, Lifestyle Intervention
Interventions: Simplified Dietary Self-Monitoring, Detailed Dietary Self-Monitoring, Core Behavioral Weight Loss Intervention; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 328 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Overweight, Obesity
Interventions: Regulation of Cues (ROC), Behavioral Weight Loss (BWL), BWL + ROC, Nutrition Education, Stress Management and Social Support; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 65 Years
Enrollment: 271 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Hypertension
Interventions: Dietitian-Assisted DASH groceries, Self-directed shopping; Behavioral
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 100 Years
Enrollment: 176 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Obesity
Interventions: Velneperit 400 mg, Orlistat 120 mg, Orlistat Placebo, Velneperit Placebo, Reduced Calorie Diet; Drug · Other
Lead sponsor: Shionogi; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 486 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 25
States / cities: Santa Rosa, California • Waterbury, Connecticut • Clearwater, Florida + 22 more

Conditions: Overweight, Obesity, Type 2 Diabetes, Prediabetes
Interventions: Weight loss diet, Weight loss diet plus exercise; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 30 Years to 65 Years
Enrollment: 77 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

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Orthostatic Hypotension Treatment on Rehab Unit

Utilizing Protein During Weight Loss to Impact Physical Function and Bone

Trial of a Water Beverage Intervention for Promoting Modest Weight Reduction in Free Living Adults

Promoting Activity and Changes in Eating (PACE) to Reduce Obesity

Effect of a 4-week Alternate Day Intermittent Energy Restriction Intervention vs Reduced

The CALERIE™ Legacy Study

The Effect of Weight Loss on Bone in Men

The TREND Study: Tapered Reduction in Energy Intake as a Novel Approach to Dieting

AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

A Study to Learn About How Food and Esomeprazole Affect the Level of BAY2927088 in the Blood When Taken Together in Healthy Participants

Liking Adaptation to Beverages With Varying Sweetness Levels After Prolonged Exposure

Comparing Tricor, Avandia, or Weight Loss to Lower Cardiovascular Risk Factors in People With High Triglycerides.

Weight Reduction Intervention for Breast Cancer Survivors

Small Extracellular Vesicles and Insulin Action

Effect of a Low-Calorie Diet and/or Exercise Program on Risk Factors for Developing Breast Cancer in Overweight or Obese Postmenopausal Women

Semaglutide and Structured Lifestyle Support to Improve Heart and Blood Vessel Health in Postmenopausal Obese Breast Cancer Survivors Taking Aromatase Inhibitors

Reducing Insulin, Growth Hormones, and Tumors

Lifestyle Modification for Obesity-Related Type 2 Diabetes

Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease

Simplifying Diet Tracking in a Digital Weight Loss Intervention

PACIFIC: Providing Adults Collaborative Interventions For Ideal Changes

Groceries for Black Residents of Boston to Stop Hypertension Among Adults With Treated Hypertension

Double-Blind, Multi-Center, Randomized Study to Assess the Efficacy and Safety of Velneperit (S-2367) and Orlistat Administered Individually or Combined With a Reduced Calorie Diet (RCD) in Obese Subjects

Evaluating the Effects of a Diet and Exercise Program in People With Type 2 Diabetes or Prediabetes: (The SHAPE3 Study)