- Conditions
- Keratoconus, Unstable, Ectasia Corneal, Bacterial Keratitis
- Interventions
- PXL 330 Platinum device/Riboflavin
- Combination Product
- Lead sponsor
- Eye Specialists of Indiana
- Other
- Eligibility
- 12 Years and older
- Enrollment
- 12 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2024
- U.S. locations
- 1
- States / cities
- Indianapolis, Indiana
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Showing 25–44
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- Conditions
- Unstable Corneas
- Interventions
- Epithelium-On Riboflavin, Epithelium-Off Riboflavin, UV Light - Continuous Beam, UV Pulsed Beam
- Drug · Device
- Lead sponsor
- Crowd Health Research, LTD
- Other
- Eligibility
- 12 Years and older
- Enrollment
- 500 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- Started 2014
- U.S. locations
- 16
- States / cities
- Santa Rosa, California • Denver, Colorado • Jacksonville, Florida + 13 more
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Interventions
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Combination Product
- Lead sponsor
- Cornea Associates of Texas
- Other
- Eligibility
- 8 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Keratoconus, Corneal Ectasia
- Interventions
- Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light
- Combination Product
- Lead sponsor
- Price Vision Group
- Industry
- Eligibility
- 10 Years to 90 Years
- Enrollment
- 500 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2031
- U.S. locations
- 1
- States / cities
- Indianapolis, Indiana
- Conditions
- Idiopathic Parkinson Disease
- Interventions
- [21CFR640.30] Plasma from 18 - 25 year old volunteer donors, Saline
- Biological · Other
- Lead sponsor
- The Neurology Center
- Other
- Eligibility
- 45 Years to 90 Years
- Enrollment
- 22 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2019
- U.S. locations
- 1
- States / cities
- Houston, Texas
- Conditions
- Keratoconus
- Interventions
- riboflavin solution, placebo solution, KXL System
- Drug · Device
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 92 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2017
- U.S. locations
- 11
- States / cities
- Irvine, California • San Diego, California • Indianapolis, Indiana + 8 more
- Conditions
- Keratoconus
- Interventions
- Riboflavin-5-phosphate, Sham cross-linking
- Drug
- Lead sponsor
- University at Buffalo
- Other
- Eligibility
- 16 Years to 35 Years
- Enrollment
- 150 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2008 – 2011
- U.S. locations
- 2
- States / cities
- Amherst, New York • Buffalo, New York
- Conditions
- Keratoconus
- Interventions
- riboflavin solution, placebo solution, KXL System
- Drug · Device
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 230 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2016
- U.S. locations
- 8
- States / cities
- San Diego, California • Indianapolis, Indiana • Overland Park, Kansas + 5 more
- Conditions
- Keratoconus
- Interventions
- riboflavin solution, placebo solution, KXL System
- Drug · Device
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 236 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2016
- U.S. locations
- 10
- States / cities
- Irvine, California • Miami, Florida • Atlanta, Georgia + 7 more
- Conditions
- Keratoconus and Ectasia
- Interventions
- Riboflavin, VEGA UV-A Illumination System
- Drug · Device
- Lead sponsor
- Topcon Medical Systems, Inc.
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 500 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2012
- U.S. locations
- 13
- States / cities
- Phoenix, Arizona • Atlanta, Georgia • Boston, Massachusetts + 7 more
- Conditions
- Keratoconus, Ectasia
- Interventions
- UVA Light with irradiance exposure of 9 mW/cm2, Riboflavin 0.1% ophthalmic solution
- Device · Drug
- Lead sponsor
- Stephen Trokel
- Other
- Eligibility
- 16 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2022
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Keratoconus, Unstable, Bacterial Keratitis, Ectasia of Cornea
- Interventions
- PXL-330 Platinum device for crosslinking with Peschke ribofflavin solution
- Combination Product
- Lead sponsor
- Pacific Clear Vision Institute
- Other
- Eligibility
- 12 Years to 45 Years
- Enrollment
- 300 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2030
- U.S. locations
- 1
- States / cities
- Eugene, Oregon
- Conditions
- Keratoconus
- Interventions
- PXL Platinum 330 system
- Device
- Lead sponsor
- Cohen Laser and Vision Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 300 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2024 – 2034
- U.S. locations
- 1
- States / cities
- Boca Raton, Florida
- Conditions
- Keratoconus
- Interventions
- The VEGA UV-A Illumination System, Riboflavin
- Device · Drug
- Lead sponsor
- Topcon Medical Systems, Inc.
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 127 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2011
- U.S. locations
- 9
- States / cities
- Phoenix, Arizona • Atlanta, Georgia • Bloomington, Minnesota + 4 more
- Conditions
- Corneal Ectasia
- Interventions
- Corneal Collagen Cross-linking
- Combination Product
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2026
- U.S. locations
- 11
- States / cities
- Palo Alto, California • Bloomington, Minnesota • Bozeman, Montana + 8 more
- Conditions
- Progressive Keratoconus
- Interventions
- riboflavin ophthalmic solution, UVA Irradiation
- Drug · Device
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 14 Years and older
- Enrollment
- 147 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2011
- U.S. locations
- 10
- States / cities
- La Jolla, California • San Diego, California • Miami, Florida + 7 more
- Conditions
- Keratitis, Corneal Ulcer
- Interventions
- PXL Platinum 330 system + Riboflavin 0.25% TE Solution, Sham CXL + Artificial Tears
- Combination Product · Other
- Lead sponsor
- Peschke GmbH
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 488 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 12
- States / cities
- Littleton, Colorado • Fort Myers, Florida • Tampa, Florida + 9 more
- Conditions
- Corneal Thinning, Keratoconus
- Interventions
- Pulsed or continuous lighting
- Combination Product
- Lead sponsor
- Vishal Jhanji
- Other
- Eligibility
- 18 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2031
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania
- Conditions
- Keratoconus, Corneal Ectasia
- Interventions
- Riboflavin
- Drug
- Lead sponsor
- Cornea and Laser Eye Institute
- Other
- Eligibility
- 12 Years and older
- Enrollment
- 170 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2025
- U.S. locations
- 1
- States / cities
- Teaneck, New Jersey
- Conditions
- Keratoconus, Corneal Ectasia
- Interventions
- Riboflavin/Dextran, Hypotonic Riboflavin
- Drug
- Lead sponsor
- Cornea and Laser Eye Institute
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 160 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2025
- U.S. locations
- 1
- States / cities
- Teaneck, New Jersey