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Conditions: Metabolic Syndrome, Obesity
Interventions: Sildenafil, Placebo; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Impotence, Prostatic Neoplasms
Interventions: Sildenafil therapy plus post-NSRRP HBO2T, Sildenafil therapy plus sham post-NSRRP HBO2T; Drug
Lead sponsor: Hartford Hospital; Other
Eligibility: 40 Years to 65 Years · Male only
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2021
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Female Sexual Health
Interventions: Sildenafil; Drug
Lead sponsor: Strategic Science & Technologies, LLC; Industry
Eligibility: 35 Years to 65 Years · Female only
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Ischemic Stroke
Interventions: Sildenafil (Viagra), Usual care; Drug · Other
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2005
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Cirrhosis
Interventions: IV bolus injection of Sildenafil; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Pulmonary Arterial Hypertension
Interventions: PDE5 inhibitor, Endothelin Receptor Antagonists; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 65 Years and older
Enrollment: 13,021 participants
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Erectile Dysfunction
Interventions: Levitra (Vardenafil, BAY38-9456), Sildenafil, Placebo; Drug
Lead sponsor: Bayer; Industry
Eligibility: 25 Years to 64 Years · Male only
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2006
U.S. locations: 18
States / cities: Phoenix, Arizona • Tempe, Arizona • Beverly Hills, California + 15 more

Conditions: Erectile Dysfunction
Interventions: Sildenafil Cream, Placebo Cream, Penile Plethysmography (RigiScan); Drug · Device
Lead sponsor: Strategic Science & Technologies, LLC; Industry
Eligibility: 18 Years to 70 Years · Male only
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 3
States / cities: San Diego, California • New Orleans, Louisiana • New York, New York

Conditions: Neurodegenerative Diseases
Interventions: Not listed
Lead sponsor: Washington D.C. Veterans Affairs Medical Center; Federal
Eligibility: 50 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Idiopathic Pulmonary Fibrosis
Interventions: Nintedanib, Placebo, Sildenafil; Drug
Lead sponsor: Boehringer Ingelheim; Industry
Eligibility: 40 Years and older
Enrollment: 274 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 17
States / cities: Birmingham, Alabama • Stamford, Connecticut • Jacksonville, Florida + 13 more

Conditions: Diabetic Neuropathy
Interventions: sildenafil (Viagra); Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: New York, New York

Conditions: Sexual Dysfunction, Depression
Interventions: sildenafil; Drug
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2005
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Impaired Glucose Tolerance
Interventions: Sildenafil, Placebo, Hyperglycemic clamp, Euglycemic clamp; Drug · Diagnostic Test
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Erectile Dysfunction
Interventions: ASP-001.1, ASP-001.1; Drug · Device
Lead sponsor: Aspargo Labs, Inc; Industry
Eligibility: 20 Years to 70 Years · Male only
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Pulmonary Arterial Hypertension, Pulmonary Hypertension
Interventions: Sitaxsentan, Placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 16 Years to 80 Years
Enrollment: 183 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 32
States / cities: Fountain Valley, California • Mather, California • Sacramento, California + 28 more

Conditions: Hypoactive Sexual Desire Disorder
Interventions: Placebo, Sildenafil, Testosterone; Drug
Lead sponsor: Emotional Brain NY Inc.; Industry
Eligibility: 21 Years to 70 Years · Female only
Enrollment: 196 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2011
U.S. locations: 14
States / cities: San Diego, California • Washington D.C., District of Columbia • Brooksville, Florida + 11 more

Conditions: Female Sexual Arousal Disorder
Interventions: Sildenafil 100 mg, Placebo; Drug
Lead sponsor: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.; Industry
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 2
States / cities: Seattle, Washington

Conditions: Persistent Pulmonary Hypertension of the Newborn
Interventions: 1 dose of sildenafil; Drug
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: Up to 364 Days
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 9
States / cities: Birmingham, Alabama • Indianapolis, Indiana • Louisville, Kentucky + 6 more

Conditions: Patent Foramen Ovale, Intrapulmonary Arteriovenous Anastamosis
Interventions: Sildenafil, Placebo; Drug · Other
Lead sponsor: University of Oregon; Other
Eligibility: 18 Years to 65 Years
Enrollment: 82 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Kidney Tumor
Interventions: sildenafil citrate, placebo, therapeutic conventional surgery; Drug · Other · Procedure
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Prostate Cancer, Male Erectile Disorder, Stage I Prostate Cancer, Stage II Prostate Cancer
Interventions: sildenafil citrate, alprostadil, robotic-assisted laparoscopic surgery, quality-of-life assessment, questionnaire administration; Drug · Procedure · Other
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 18 Years to 65 Years · Male only
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Duarte, California

Conditions: Fontan Circulation
Interventions: Sildenafil 10mg oral tablet (participants <20kg), or 20mg oral tablet (participants ≥20kg), Pravastatin 20 mg oral tablet (ages <13 years), or 40 mg oral tablet (≥14 years); Drug
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: 8 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Hypertension, Pulmonary Artery, Ventricular Dysfunction, Left
Interventions: sildenafil; Drug
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 80 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Erectile Dysfunction, Testosterone Deficiency, Diabetes
Interventions: Sildenafil citrate (open label), Testosterone gel, Placebo gel; Drug · Other
Lead sponsor: Boston University; Other
Eligibility: 40 Years to 70 Years · Male only
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

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Study of Sildenafil Citrate on Insulin Resistance in African American

Can Hyperbaric Oxygen Improve Erectile Function Following Surgery for Prostate Cancer

A Open-Label, Within-Subject Dose-Escalation Study to Evaluate the Clinical Safety and Pharmacokinetic Profile of a Topical Sildenafil Cream (5% w/w), in Healthy Postmenopausal Women

Sildenafil (Viagra) Treatment of Subacute Ischemic Stroke

A Phase 1, Open-Label Study of Intravenous Sildenafil in Patients With Cirrhosis

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - PDE5

Assess the Effect of Daily Treatment of Vardenafil 20mg or Sildenafil 100mg and Placebo on Sperm Function

Phase 2a Topical Sildenafil Proof-of-Concept Study in Men With Mild to Moderate ED

Cerebrovascular Reactivity and Oxygen Metabolism as Markers of Neurodegeneration After Traumatic Brain Injury

Efficacy and Safety of Nintedanib Co-administered With Sildenafil in Idiopathic Pulmonary Fibrosis Patients With Advanced Lung Function Impairment

An Open Label, Dose Finding Trial of Viagra for the Treatment of Neuropathic Pain (in Diabetes Mellitus)

Study of Sildenafil for Treatment of SSRI-Antidepressant Sexual Dysfunction in Women

Renin-Angiotensin and Fibrinolysis in Humans: Effect of Long-Term PDE5 Inhibition on Glucose Homeostasis

The Objective of This Phase 1 Study is to Evaluate the Food Effect of 100 mg Hezkue Turbo® (ASP-001.1, Sildenafil) Under Fed Versus 100 mg of Hezkue Turbo® (ASP-001.1, Sildenafil) Under Fasted Conditions in Healthy Adult Male Subjects

Sitaxsentan Efficacy And Safety Trial With A Randomized Prospective Assessment Of Adding Sildenafil (SR-PAAS)

Lybrido for Female Sexual Dysfunction

Study to Investigate Effect of Sildenafil on Clitoral Engorgement as Measured by Magnetic Resonance Imaging (MRI) in Pre-menopausal Women With Female Sexual Arousal Disorder

Pharmacokinetics of Sildenafil in Premature Infants

Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?

Sildenafil Citrate Before Surgery in Improving Kidney Function in Patients With Kidney Cancer

ED Recovery in Men Age </=65 Treated With Bilateral Nerve Sparing Robotic Assisted Prostatectomy for Prostate Cancer

IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease

Characterization of LV Strain Patterns in Mildly Elevated PCWP and PAH.

Effect of Testosterone in Men With Erectile Dysfunction