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ClinicalTrials.gov public records Last synced Sep 25, 2026, 9:33 PM EDT

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Showing 1–24 of 146 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: tissue plasminogen activator, tPA Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Inhaled Tissue Plasminogen Activator for Acute Plastic Bronchitis

NCT02315898
View directory record Official record
Conditions
Plastic Bronchitis, Protein-Losing Enteropathies, Healthy
Interventions
Treatment-inhaled tPA
Drug
Lead sponsor
University of Michigan
Other
Eligibility
5 Years to 24 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
6
States / cities
Palo Alto, California • Chicago, Illinois • Ann Arbor, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Sep 25, 2026, 9:33 PM EDT
Completed No phase listed Observational

New York City Mobile Interventional Stroke Team

NCT03048292
View directory record Official record
Conditions
Acute Stroke
Interventions
Acute Endovascular Stroke Treatment
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
191 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 25, 2026, 9:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pharmacogenetics of Ace Inhibitor-Associated Angioedema

NCT01413542
View directory record Official record
Conditions
Hypertension, Diabetes Type 2
Interventions
Sitagliptin (DPP4 inhibitor), Substance P,, bradykinin, enalaprilat (ACE inhibitor), Glucagon-like peptide 1, brain natriuretic peptide
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 3, 2015 · Synced Sep 25, 2026, 9:33 PM EDT
Recruiting Phase 2 Interventional

Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +]

NCT06713382
View directory record Official record
Conditions
Pleural Effusion Associated With Pulmonary Infection, Pleural Effusion Disorder, Pleural Effusions
Interventions
Pleural Saline Irrigation
Combination Product
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 25, 2026, 9:33 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Valsartan and the Combination of Valsartan and Simvastatin

NCT00385931
View directory record Official record
Conditions
Hypertension, Hypercholesterolemia, Dyslipidemia
Interventions
Valsartan and simvastatin
Drug
Lead sponsor
Novartis
Industry
Eligibility
50 Years and older
Enrollment
412 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 8, 2023 · Synced Sep 25, 2026, 9:33 PM EDT
Withdrawn Phase 4 Interventional

Early Intrapleural TPA Instillation Versus Late

NCT03167281
View directory record Official record
Conditions
Tissue Plasminogen Activator
Interventions
early tPA and DNase
Combination Product
Lead sponsor
Prisma Health-Midlands
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2025 · Synced Sep 25, 2026, 9:33 PM EDT
Terminated Phase 2 Interventional Results available

Study of Tenecteplase (TNK) in Acute Ischemic Stroke (TNK-S2B)

NCT00252239
View directory record Official record
Conditions
Stroke
Interventions
tenecteplase, tissue plasminogen activator, tPA
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
9
States / cities
San Diego, California • Englewood, Colorado • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2015 · Synced Sep 25, 2026, 9:33 PM EDT
Recruiting Phase 2Phase 3 Interventional

Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial

NCT06949228
View directory record Official record
Conditions
Ischemic Stroke, Acute Disease
Interventions
tenecteplase
Drug
Lead sponsor
ProMedica Health System
Other
Eligibility
18 Years to 85 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 25, 2026, 9:33 PM EDT
Completed Not applicable Interventional

IV vs. IA tPA (Activase) in Acute Ischemic Stroke With CTA Evidence of Major Vessel Occlusion

NCT00624000
View directory record Official record
Conditions
Ischemic Stroke
Interventions
IV tpa (Alteplase) vs IA tpa (Alteplase)
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
19 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2011 · Synced Sep 25, 2026, 9:33 PM EDT
Active, not recruiting Phase 4 Interventional

Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE

NCT03581877
View directory record Official record
Conditions
Pulmonary Embolism, Pulmonary Hypertension, Thromboembolism, Right Ventricular Dysfunction
Interventions
Alteplase, EKOS
Drug · Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 89 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
Bay Shore, New York • Queens, New York
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Sep 25, 2026, 9:33 PM EDT
Not listed Phase 2Phase 3 Interventional

BEnefits of Stroke Treatment Delivered Using a Mobile Stroke Unit

NCT02190500
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Mobile Stroke Unit Management
Other
Lead sponsor
Memorial Hermann Health System
Other
Eligibility
18 Years and older
Enrollment
1,038 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 16, 2023 · Synced Sep 25, 2026, 9:33 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

CLOTBUST Hands-Free: A Phase I/II Pilot Safety Trial

NCT01240356
View directory record Official record
Conditions
Stroke
Interventions
2-MHz transcranial Doppler ultrasound, 2-MHz transcranial Doppler ultrasound insonation
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
2
States / cities
Birmingham, Alabama • Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 22, 2016 · Synced Sep 25, 2026, 9:33 PM EDT
Terminated Phase 2 Interventional Results available

Safety of Rt-PA + Transcranial Emission of Low-Energy Lasers for Acute Stroke Recovery

NCT01220739
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Transcranial Laser Therapy
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
3
States / cities
Englewood, Colorado • Columbia, South Carolina • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Dec 4, 2016 · Synced Sep 25, 2026, 9:33 PM EDT
Not listed Phase 1 Interventional

Combination Tissue Plasminogen Activator (Tpa) and Dornase Alfa (Dnase) Administration Through Intrapleural Catheters for the Treatment of Loculated or Non-Draining Malignant Pleural Effusions

NCT02135588
View directory record Official record
Conditions
Loculated or Non-draining Malignant Pleural Effusions
Interventions
Combination TISSUE PLASMINOGEN ACTIVATOR (TPA) AND DORNASE ALFA (DNASE)
Drug
Lead sponsor
Eastern Regional Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 10, 2021 · Synced Sep 25, 2026, 9:33 PM EDT
Withdrawn Phase 1 Interventional

Study for the Use of Alteplase in Patients Who Awaken With Stroke

NCT01150266
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Alteplase (tPA)
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
22 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 12, 2013 · Synced Sep 25, 2026, 9:33 PM EDT
Completed Phase 2 Interventional Results available

Minimally Invasive Surgery and rtPA for Intracerebral Hemorrhage Evacuation

NCT00224770
View directory record Official record
Conditions
Intracerebral Hemorrhage
Interventions
MIS+Cathflo Activase (drug), Intraoperative stereotactic CT-Guided Endoscopic Surgery
Drug · Procedure
Lead sponsor
Daniel Hanley
Other
Eligibility
18 Years to 80 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
26
States / cities
Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2015 · Synced Sep 25, 2026, 9:33 PM EDT
Terminated Phase 2 Interventional Results available

Randomized Controlled Trial of Argatroban With Tissue Plasminogen Activator (tPA) for Acute Stroke

NCT01464788
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Low Dose Argatroban, High Dose Argatroban, rt-PA (alteplase)
Drug
Lead sponsor
Andrew D. Barreto, MD
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Sep 25, 2026, 9:33 PM EDT
Completed Phase 4 Interventional Results available

Fibrinolysis Compared to Thoracoscopy for Pleural Infection

NCT03468933
View directory record Official record
Conditions
Pleural Infection, Empyema, Pleural Diseases, Parapneumonic Effusion
Interventions
tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase), Medical Thoracoscopy
Drug · Procedure
Lead sponsor
Tulane University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Sep 25, 2026, 9:33 PM EDT
Not listed No phase listed Observational

Biomarkers of Acute Stroke in Clinic

NCT03897478
View directory record Official record
Conditions
Ischemic Stroke, Ischemia, Atrial Fibrillation, Transient Ischemic Attack, Transient Cerebrovascular Events, Thrombotic Stroke, Stroke, Stroke, Acute, Stroke, Ischemic, Stroke, Complication, Stroke of Basilar Artery, Atherosclerosis, Atheroma, Cardioembolic Stroke, Cardiomyopathies, Cardiovascular Stroke, Thromboembolism
Interventions
ISCDX blood test
Diagnostic Test
Lead sponsor
Ischemia Care LLC
Industry
Eligibility
18 Years to 80 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 25, 2026, 9:33 PM EDT
Completed Phase 2 Interventional Results available

A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients

NCT01282242
View directory record Official record
Conditions
Acute Stroke
Interventions
IV rt-PA
Drug
Lead sponsor
Lee Schwamm
Other
Eligibility
18 Years to 85 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
14
States / cities
Tucson, Arizona • Los Angeles, California • Chicago, Illinois + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2017 · Synced Sep 25, 2026, 9:33 PM EDT
Terminated Not applicable Interventional

Helping Stroke Patients With ThermoSuit Cooling

NCT02453373
View directory record Official record
Conditions
Stroke, Brain Ischemia
Interventions
ThermoSuit Cooling Induction, Magnesium Sulfate, tPA, Propofol, Etomidate, Neurothrombectomy
Device · Drug · Procedure
Lead sponsor
Life Recovery Systems
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
4
States / cities
New Orleans, Louisiana • Danville, Pennsylvania • Wilkes-Barre, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Sep 25, 2026, 9:33 PM EDT
Recruiting No phase listed Observational

Complex Adult Deformity Surgery (CADS)

NCT04194138
View directory record Official record
Conditions
Adult Spinal Deformity, Scoliosis, Kyphosis, Sagittal Imbalance
Interventions
Index or spine revision surgery for complex adult spinal deformity
Procedure
Lead sponsor
International Spine Study Group Foundation
Other
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2032
U.S. locations
17
States / cities
La Jolla, California • Sacramento, California • San Francisco, California + 11 more
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 25, 2026, 9:33 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Tenecteplase (TNK) for Loculated Pleural Effusions in Patients With Malignancy

NCT01580618
View directory record Official record
Conditions
Pleural Effusion
Interventions
normal saline, TNK (Tenecteplase)
Drug
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 25, 2026, 9:33 PM EDT
Withdrawn Phase 1 Interventional

Treatment of Acute Respiratory Distress Syndrome With Tenecteplase: A Dose Escalation Pilot Study

NCT00431379
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome
Interventions
Tenecteplase
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Macon, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 25, 2026, 9:33 PM EDT