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ClinicalTrials.gov public records Last synced Oct 9, 2026, 5:11 PM EDT

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Showing 97–120 of 129 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: transcutaneous auricular nerve stimulation Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

NCT07424365
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
Interventions
transcutaneous auricular vagus nerve stimulation, sham stimulation
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Completed Not applicable Interventional Results available

Addressing Disparities in Neuromodulation for Rehabilitation: A Mixed Methods Approach to Optimize Access for Underrepresented Racial Minorities

NCT05896202
View directory record Official record
Conditions
Neuropathic Pain
Interventions
taVNS Video, Educational materials, TMS Video
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 80 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Oct 9, 2026, 5:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Combined Effect of TENS and TaVNS on Pressure and Heat Pain Thresholds in Pain-Free Subjects

NCT06361381
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Active Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS), Placebo Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS), Transcutaneous Electrical Nerve Stimulation
Device
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
West Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 6, 2024 · Synced Oct 9, 2026, 5:11 PM EDT
Recruiting Not applicable Interventional

A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness

NCT07420803
View directory record Official record
Conditions
Chronic Dizziness, Persistent Postural Perceptual Dizziness
Interventions
Sham Device, Auricular transcutaneous vagus nerve stimulation
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

taVNS-Paired Breastfeeding to Improve Breastfeeding at Discharge

NCT06417385
View directory record Official record
Conditions
Premature Birth, Breastfeeding, Exclusive, Feeding; Difficult, Newborn
Interventions
taVNS soterix device
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
35 Weeks and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Active, not recruiting Not applicable Interventional

Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health

NCT07812987
View directory record Official record
Conditions
Anxiety, PTSD, ADHD, Depression Disorders, Post-traumatic Stress, Substance Use, Executive Function, Sleep Disturbance
Interventions
AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation, Audiovisual Entrainment, Vibroacoustic Stimulation, Breathwork-Based Auditory Driving Entropy Module (BADEM), Transcranial Electrical Stimulation
Behavioral · Device
Lead sponsor
Tactical Mind Research Coalition, Inc.
Other
Eligibility
18 Years to 70 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Not yet recruiting Not applicable Interventional

TENS of Auricular Vagal Nerve for Radiation Necrosis

NCT07680127
View directory record Official record
Conditions
Radiation Necrosis, Cerebral Edema
Interventions
Transcutaneous auricular vagal nerve stimulation (taVNS), Sham
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Completed Not applicable Interventional

Delivering Transcutaneous Auricular Neurostimulation to Reduce Heavy Menstrual Bleeding in Patients With and Without Von Willebrand Disease

NCT06064851
View directory record Official record
Conditions
Von Willebrand Disease, Type 1, Heavy Menstrual Bleeding
Interventions
Volta System
Device
Lead sponsor
Five Liters, Inc.
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 9, 2026, 5:11 PM EDT
Not yet recruiting Not applicable Interventional

Transcutaneous Auricular Vagus Nerve Stimulation for Attenuation of Inflammatory Response and Blood Pressure in Type B Aortic Dissection

NCT07534722
View directory record Official record
Conditions
Type B Aortic Dissection
Interventions
Auricular Vagus Nerve Stimulator, 3D Printed Earpiece
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Recruiting Phase 1 Interventional

Using taVNS to Modulate Cardiovascular Function in Individuals With Neurologic Disease

NCT07557706
View directory record Official record
Conditions
PARKINSON DISEASE (Disorder)
Interventions
transcutaneous auricular vagus nerve stimulation
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Completed Not applicable Interventional

Vagus Auricular Stimulation for Tinnitus

NCT06821893
View directory record Official record
Conditions
Tinnitus
Interventions
Vibrational stimulation, Sham
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 14, 2025 · Synced Oct 9, 2026, 5:11 PM EDT
Completed Not applicable Interventional

taVNS for Anxiety in ASD

NCT06258590
View directory record Official record
Conditions
Autism Spectrum Disorder, Anxiety
Interventions
Transcutaneous auricular vagus nerve stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Locus Coeruleus, Norepinephrine and Cognitive Aging

NCT06880510
View directory record Official record
Conditions
Alzheimer Disease
Interventions
t-VNS transcutaneous auricular vagus nerve stimulator
Device
Lead sponsor
Cornell University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Transcutaneous Electric Nerve Stimulation (TENS) for Vagal Modulation

NCT05987813
View directory record Official record
Conditions
Functional Gastrointestinal Disorders
Interventions
TENS Unit
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
12 Years to 21 Years · Female only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 9, 2026, 5:11 PM EDT
Recruiting Not applicable Interventional

Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke

NCT07404852
View directory record Official record
Conditions
Large Vessel Occlusion, Acute Ischemic Stroke
Interventions
transcutaneous auricular vagal nerve stimulation, Sham transcutaneous vagal nerve stimulation
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 99 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Recruiting Not applicable Interventional

taVNS + CCT for Neurocognitive Rehab

NCT07517237
View directory record Official record
Conditions
Psychosocial Well-being, Neurocognitive Function, Cognitive Complaint, Cognitive Dysfunction
Interventions
taVNS, Computerized Cognitive Training
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
45 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Withdrawn Not applicable Interventional

Using Transcutaneous Auricular Vagus Nerve Stimulation to Treat Acute Alcohol Withdrawal

NCT04159909
View directory record Official record
Conditions
Alcohol Withdrawal, Alcohol Use Disorder
Interventions
Transcutaneous Nerve Stimulation, Sham Stimulation
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Mar 13, 2024 · Synced Oct 9, 2026, 5:11 PM EDT
Active, not recruiting Not applicable Interventional

Neurostimulation to Improve NOWS Outcomes

NCT05129020
View directory record Official record
Conditions
Neonatal Opioid Withdrawal Syndrome, Neonatal Abstinence Syndrome
Interventions
Sparrow Fledging Therapy System, Sham Sparrow Fledging Therapy System
Device
Lead sponsor
Spark Biomedical, Inc.
Industry
Eligibility
33 Weeks to 1 Year
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
3
States / cities
Charleston, South Carolina • Dallas, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Completed Not applicable Interventional Results available

BabyStrong Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Paired Bottle Feeding to Improve Oral Feeding

NCT04849507
View directory record Official record
Conditions
Infant Feeding Problems, taVNS
Interventions
transcutaneous auricular vagus nerve stimulation, Sham transcutaneous auricular vagus nerve stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
2 Weeks to 5 Months
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Oct 9, 2026, 5:11 PM EDT
Recruiting Not applicable Interventional

A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)

NCT05583942
View directory record Official record
Conditions
Nephrotic Syndrome in Children, Minimal Change Disease, Focal Segmental Glomerulosclerosis
Interventions
trascutaneous auricular vagus nerve stimulation, Sham device
Device
Lead sponsor
Northwell Health
Other
Eligibility
3 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
New Hyde Park, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Stimulation on the Vagus Nerve

NCT04206540
View directory record Official record
Conditions
Healthy Subjects
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation, Vagal Stimulation
Device · Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 9, 2026, 5:11 PM EDT
Completed Not applicable Interventional

Delivering Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention in Opioid Use Disorder

NCT05053503
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Withdrawal
Interventions
Sparrow Ascent Therapy System, Lofexidine, Extended-release injectable naltrexone
Device · Drug
Lead sponsor
Spark Biomedical, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
4
States / cities
Rancho Mirage, California • Crownsville, Maryland • Center City, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 4, 2025 · Synced Oct 9, 2026, 5:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

taVNS Cold Pressor

NCT05254080
View directory record Official record
Conditions
taVNS, Brain Stimulation
Interventions
Active taVNS, Sham taVNS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Oct 9, 2026, 5:11 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Transcutaneous Auricular Vagus Nerve Stimulation to Enhance Motor Learning

NCT05316519
View directory record Official record
Conditions
Neurological Injury, Motor Disorders, Paresis
Interventions
Transcutaneous Vagus Nerve Stimulation
Other
Lead sponsor
VA Pittsburgh Healthcare System
Federal
Eligibility
18 Years to 75 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Oct 9, 2026, 5:11 PM EDT