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ClinicalTrials.gov public records Last synced Oct 2, 2026, 8:06 AM EDT

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Showing 49–72 of 299 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: vagal nerve stimulation Clear all
Not yet recruiting Not applicable Interventional

Trans Auricular Vagal Nerve Stimulation in Patients With IBS-C

NCT07662083
View directory record Official record
Conditions
Irritable Bowel Syndrome (IBS-C)
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS), Sham Transcutaneous Auricular Vagus Nerve Stimulation
Device
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 2, 2026, 8:06 AM EDT
Completed Not applicable Interventional

Delivering Transcutaneous Auricular Neurostimulation to Reduce Heavy Menstrual Bleeding in Patients With and Without Von Willebrand Disease

NCT06064851
View directory record Official record
Conditions
Von Willebrand Disease, Type 1, Heavy Menstrual Bleeding
Interventions
Volta System
Device
Lead sponsor
Five Liters, Inc.
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 2, 2026, 8:06 AM EDT
Not listed Not applicable Interventional

Effect of taVNS on Heart Rate in Persistent Atrial Fibrillation

NCT05944575
View directory record Official record
Conditions
Atrial Fibrillation, Persistent
Interventions
active taVNS, sham-taVNS
Device
Lead sponsor
Burrell College of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Las Cruces, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 14, 2023 · Synced Oct 2, 2026, 8:06 AM EDT
Active, not recruiting Not applicable Interventional

Leverage Noninvasive Transcutaneous Vagus Nerve Stimulation to Reduce Suicidal Behaviors in Vulnerable Adolescents

NCT05602779
View directory record Official record
Conditions
Self Harm, Suicidal Ideation
Interventions
tVNS Program, Phone App Program, tVNS and Phone App Program, Sham tNVS and Control App
Device · Other · Combination Product
Lead sponsor
University of Notre Dame
Other
Eligibility
13 Years to 17 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
South Bend, Indiana • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 2, 2026, 8:06 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Imaging Brain Fluids During Breathing

NCT05180981
View directory record Official record
Conditions
Healthy
Interventions
Transcutaneous vagal nerve stimulation, Breathing task
Device · Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 70 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 2, 2026, 8:06 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

NCT07424365
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
Interventions
transcutaneous auricular vagus nerve stimulation, sham stimulation
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 2, 2026, 8:06 AM EDT
Completed Not applicable Interventional Results available

taVNS in Mild to Moderate Parkinson's Disease

NCT04157621
View directory record Official record
Conditions
Parkinson Disease
Interventions
Active taVNS, Sham Stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
40 Years to 79 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Oct 2, 2026, 8:06 AM EDT
Not listed Not applicable Interventional

Respiratory-gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) Study in Ulcerative Colitis

NCT05662059
View directory record Official record
Conditions
Ulcerative Colitis
Interventions
RAVANS, RAVANS-sham
Device
Lead sponsor
Cala Health, Inc.
Industry
Eligibility
10 Years to 39 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Lake Success, New York
Source: ClinicalTrials.gov public record
Updated Mar 17, 2023 · Synced Oct 2, 2026, 8:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Noninvasive VNS to Facilitate Excitability in Motor Cortex

NCT04130646
View directory record Official record
Conditions
Stroke, Stroke Sequelae, Motor Activity
Interventions
Transcranial Magnetic Stimulation, transcutaneous auricular vagus nerve stimulation (taVNS)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2025 · Synced Oct 2, 2026, 8:06 AM EDT
Recruiting Phase 2Phase 3 Interventional

A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation

NCT07487818
View directory record Official record
Conditions
Smoking Cessation
Interventions
Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches
Combination Product · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 2, 2026, 8:06 AM EDT
Recruiting Not applicable Interventional

Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome

NCT05212129
View directory record Official record
Conditions
Functional Gastrointestinal Disorders, Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome, Autonomic Nervous System Disease, Autonomic Nervous System Imbalance
Interventions
Percutaneous vagal nerve stimulation (pVNS) device, Acoustic vagal nerve stimulation (aVNS) treatment
Device · Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
10 Years to 18 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 2, 2026, 8:06 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Potential Benefit for Non Invasive Vagus Nerve Stimulation Using GammaCore in the Treatment of Raynaud's Phenomena.

NCT03869008
View directory record Official record
Conditions
Raynaud Phenomenon, Primary Raynaud Phenomenon, Raynaud Disease, Raynaud Syndrome
Interventions
gammaCore Sapphire, Sham Device
Device
Lead sponsor
University of Toledo Health Science Campus
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Oct 2, 2026, 8:06 AM EDT
Terminated Not applicable Interventional

ANTHEM-HFrEF Pivotal Study

NCT03425422
View directory record Official record
Conditions
Heart Failure, Heart Failure, Congestive, Heart Failure, Systolic
Interventions
VITARIA System
Device
Lead sponsor
LivaNova
Industry
Eligibility
18 Years and older
Enrollment
533 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
22
States / cities
Birmingham, Alabama • Tucson, Arizona • Little Rock, Arkansas + 19 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2023 · Synced Oct 2, 2026, 8:06 AM EDT
Completed Not applicable Interventional Results available

Noninvasive Neuromodulation to Reserve Diastolic Dysfunction

NCT02983448
View directory record Official record
Conditions
Heart Failure, Diastolic
Interventions
transcutaneous vagus nerve stimulation
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Oct 2, 2026, 8:06 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Vagal Nerve Stimulation to Reduce Inflammation and Hyperadrenergia

NCT02983266
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
InTENsity MicroCombo
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced Oct 2, 2026, 8:06 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Assessment of Effect of Vagal Nerve Stimulator (VNS) on Electrocorticograms Recorded by Responsive Neurostimulator (RNS) in Patients With Drug Resistant Epilepsy

NCT03595072
View directory record Official record
Conditions
Epilepsy
Interventions
observation of VNS stimulation effects
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 7, 2023 · Synced Oct 2, 2026, 8:06 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Pilot Testing of Vagus Nerve Stimulation for Early Spinal Cord Injury Recovery

NCT07562113
View directory record Official record
Conditions
Spinal Cord Injuries (Complete and Incomplete)
Interventions
Transauricular vagus nerve stimulation
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 89 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 2, 2026, 8:06 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Transauricular Vagus Nerve Stimulation in Children

NCT06168071
View directory record Official record
Conditions
Hypoxia-Ischemia, Brain
Interventions
taVNS
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
7 Years to 18 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 2, 2026, 8:06 AM EDT
Not yet recruiting Not applicable Interventional

taVNS in Veterans With Knee OA (AVAHCS)

NCT07804199
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Methylprednisolone acetate, taVNS
Drug · Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
45 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 2, 2026, 8:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Learning and Ear Stimulation

NCT04812015
View directory record Official record
Conditions
Learning, taVNS
Interventions
transcutaneous auricular vagus nerve stimulation (taVNS) 15 minutes, taVNS 30 minutes, taVNS 45 minutes, taVNS 60 minutes, taVNS 75 minutes, taVNS 0 minutes
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Oct 2, 2026, 8:06 AM EDT
Recruiting Not applicable Interventional

VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems

NCT03953768
View directory record Official record
Conditions
Autoimmune Diseases, Epilepsy, Autonomic Dysfunction, Inflammatory Bowel Diseases
Interventions
Vagal nerve stimulation (VNS)
Device
Lead sponsor
University of Louisville
Other
Eligibility
0 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
4
States / cities
Louisville, Kentucky • Houston, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Oct 2, 2026, 8:06 AM EDT
Recruiting Not applicable Interventional

Transcutaneous Vagus Nerve Stimulation for Attention and Memory

NCT06723743
View directory record Official record
Conditions
Traumatic Brain Injury (TBI) Patients
Interventions
Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
Other · Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
25 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 2, 2026, 8:06 AM EDT
Completed Not applicable Interventional Results available

Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression

NCT04448327
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
active tVNS, Sham tVNS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 2, 2026, 8:06 AM EDT
Recruiting Not applicable Interventional

Self-applied taVNS for CIPN

NCT07596030
View directory record Official record
Conditions
Chemotherapy Induced Peripheral Neuropathy
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Oct 2, 2026, 8:06 AM EDT