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ClinicalTrials.gov public records Last synced Oct 8, 2026, 1:40 AM EDT

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Showing 25–48 of 56 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: Laureate Institute for Brain Research, Inc. Clear all
Terminated Phase 2 Interventional Results available

Adherence to Antidepressant Treatment in Subjects With Depression

NCT03388164
View directory record Official record
Conditions
Depression
Interventions
Escitalopram + RT2CK17, Escitalopram + Placebo
Drug
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Oct 8, 2026, 1:40 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Pilot Study on the Clinical Utility of the Tulsa Life Chart

NCT05523843
View directory record Official record
Conditions
Mental Health Issue, Mental Health Disorder, Assessment, Self
Interventions
Tulsa Life Chart (TLC)
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
15 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 8, 2026, 1:40 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Decoding Emotional Dynamics in Bipolar Disorder

NCT07221864
View directory record Official record
Conditions
Bipolar Disorder I or II, Healthy (Controls)
Interventions
Think and Regulate Affective State Task
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 8, 2026, 1:40 AM EDT
Suspended Not applicable Interventional

Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression

NCT04934553
View directory record Official record
Conditions
Alcoholism, Alcohol Drinking, Drinking Behavior, Alcohol-Related Disorders, Substance-Related Disorders, Mental Disorder, Anxiety, Depression
Interventions
Amplification of Positivity Training, Cognitive-behavioral Therapy
Behavioral
Lead sponsor
Charles Taylor
Other
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
2
States / cities
La Jolla, California • Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Oct 8, 2026, 1:40 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Study of Ibuprofen Effects on Brain Function

NCT02507219
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Ibuprofen
Drug
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 23, 2018 · Synced Oct 8, 2026, 1:40 AM EDT
Recruiting Phase 4 Interventional

Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression

NCT06004115
View directory record Official record
Conditions
Depression, Anxiety, Fear, Depression, Anxiety and Fear, Anxiety Disorders, Anxious Depression
Interventions
Lorazepam, Placebo
Drug · Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 8, 2026, 1:40 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Gastrointestinal Interoception in Anorexia Nervosa

NCT05111977
View directory record Official record
Conditions
Anorexia Nervosa
Interventions
Vibrant capsule
Device
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
15 Years to 40 Years · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 10, 2024 · Synced Oct 8, 2026, 1:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression

NCT05697172
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Low-intensity focused ultrasound
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Oct 8, 2026, 1:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neurophysiological and Immunological Effects of the Transition From Combustible to Electronic Cigarettes

NCT02433015
View directory record Official record
Conditions
Tobacco Smoking, Nicotine Dependence
Interventions
Electronic Cigarette, Tobacco Cigarette
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 50 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 28, 2017 · Synced Oct 8, 2026, 1:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Self-regulation of Prefrontal Cortex During Emotional Cognitive Control

NCT04543500
View directory record Official record
Conditions
Healthy Volunteers, Cognitive Function
Interventions
Real-time functional magnetic resonance neurofeedback (rtfMRI-nf)
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 19, 2022 · Synced Oct 8, 2026, 1:40 AM EDT
Completed Phase 1 Interventional Results available

Lipopolysaccharide (LPS) Challenge in Depression

NCT03142919
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Lipopolysaccharide, Placebo
Biological
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Oct 8, 2026, 1:40 AM EDT
Recruiting Not applicable Interventional

Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression

NCT07166289
View directory record Official record
Conditions
Treatment-Resistant Depression
Interventions
Low-intensity focused ultrasound
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 8, 2026, 1:40 AM EDT
Completed Not applicable Interventional

Effects of Reduced Environmental Stimulation on Eating Disorders

NCT02801084
View directory record Official record
Conditions
Anorexia Nervosa
Interventions
Reduced environmental stimulation
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 15, 2022 · Synced Oct 8, 2026, 1:40 AM EDT
Completed Not applicable Interventional

Cerebellar Neuromodulation to Enhance Fear Extinction and Predict Response to Exposure Therapy

NCT03275337
View directory record Official record
Conditions
Anxiety Disorders, Social Phobia
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Oct 8, 2026, 1:40 AM EDT
Recruiting Not applicable Interventional

Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa

NCT06332963
View directory record Official record
Conditions
Anorexia Nervosa, Body Image Disturbance, Interoception
Interventions
Floatation-REST, IFT, EFT
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
13 Years to 50 Years · Female only
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 26, 2025 · Synced Oct 8, 2026, 1:40 AM EDT
Recruiting Phase 1Phase 2 Interventional

Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression

NCT06088732
View directory record Official record
Conditions
Bipolar Depression
Interventions
Exercise Session, Ibuprofen 800 mg, Rest, Placebo
Other · Drug
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 23, 2025 · Synced Oct 8, 2026, 1:40 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Latent Structure of Multi-level Assessments and Predictors of Outcomes in Psychiatric Disorders

NCT02450240
View directory record Official record
Conditions
Depression, Anxiety, Eating Disorders, Drug Use Disorders
Interventions
standardized diagnostic assessment, self-report questionnaires, behavioral tasks, physiological measurements, structural and functional magnetic resonance imaging and EEG, biomarker and microbiome assessments, blood to derive induced pluripotent stem cells, genetic and epigenetic assessments
Behavioral · Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
1,271 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Oct 8, 2026, 1:40 AM EDT
Completed Not applicable Interventional

Neurocognitive Empowerment for Addiction Treatment (NEAT) in Opioid Use Disorder and Amphetamine Use Disorder

NCT03922646
View directory record Official record
Conditions
Opioid-use Disorder, Amphetamine Use Disorders
Interventions
Neurocognitive Empowerment for Addiction Treatment (NEAT), Active Control
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 28, 2023 · Synced Oct 8, 2026, 1:40 AM EDT
Completed Not applicable Interventional

Affective Modulation of Positivity for Alcohol Use Disorder

NCT04278365
View directory record Official record
Conditions
Anxiety, Depression, Alcohol Use Disorder
Interventions
Positive affect training
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Oct 8, 2026, 1:40 AM EDT
Not listed Not applicable Interventional

Floatation-REST (Reduced Environmental Stimulation Therapy) for Anxiety and Depression

NCT03899090
View directory record Official record
Conditions
Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia, Posttraumatic Stress Disorder, Major Depressive Disorder
Interventions
Float pool, Float chair
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 60 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 5, 2023 · Synced Oct 8, 2026, 1:40 AM EDT
Completed Phase 2 Interventional Results available

A Double-Blind Trial of Adjunctive Valacyclovir to Improve Cognition in Early Phase Schizophrenia

NCT02008773
View directory record Official record
Conditions
Schizophrenia
Interventions
Valacyclovir HCI 500 mg tablets, placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
13
States / cities
Bellflower, California • Los Angeles, California • Riverside, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2019 · Synced Oct 8, 2026, 1:40 AM EDT
Recruiting Not applicable Interventional

Amplification of Positivity for Alcohol Use

NCT06030154
View directory record Official record
Conditions
Alcohol Use Disorder, Anxiety, Depression
Interventions
Cognitive Behavioral Therapy, Amplification of Positivity Therapy, Surveys and Interviews
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 18, 2025 · Synced Oct 8, 2026, 1:40 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Dose-Dependent Effects of Low-Intensity Focused Ultrasound

NCT07099950
View directory record Official record
Conditions
Healthy Controls
Interventions
Low-intensity focused ultrasound
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 8, 2026, 1:40 AM EDT
Recruiting Not applicable Interventional

LIFU Mechanisms for PTSD in Healthcare Workers

NCT07164105
View directory record Official record
Conditions
PTSD and Trauma-related Symptoms
Interventions
Low intensity focused ultrasound, Sham modulation
Device
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 8, 2026, 1:40 AM EDT