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ClinicalTrials.gov public records Last synced Oct 8, 2026, 9:53 PM EDT

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Showing 25–48 of 109 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: Smith & Nephew, Inc. Clear all
Completed Not applicable Interventional Results available

Agili-C™ Implant Performance Evaluation

NCT03299959
View directory record Official record
Conditions
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Interventions
Agili-C implant, SSOC
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
11
States / cities
San Diego, California • New Orleans, Louisiana • Salisbury, Maryland + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 8, 2026, 9:53 PM EDT
Terminated Not applicable Interventional Results available

Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)

NCT01084772
View directory record Official record
Conditions
Degenerative Arthritis of Knee
Interventions
VISIONAIRE Total Knee Arthroplasty, Standard Total Knee Arthroplasty
Other
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
6
States / cities
Park Ridge, Illinois • Springfield, Illinois • St Louis, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2020 · Synced Oct 8, 2026, 9:53 PM EDT
Completed Not applicable Interventional Results available

Achilles Tendon Repair With Bioinductive Implant

NCT02811003
View directory record Official record
Conditions
Tendinopathy
Interventions
Rotation Medical Bioinductive Implant
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Baltimore, Maryland • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 4, 2022 · Synced Oct 8, 2026, 9:53 PM EDT
Completed Not applicable Interventional

A Comparison of Post-Sternotomy Dressings

NCT02198066
View directory record Official record
Conditions
Impaired Wound Healing, Postoperative Wound Infection-deep
Interventions
Dry Sterile Dressing, Metallic Silver Dressing, Ionic Silver Dressing
Other
Lead sponsor
Carilion Clinic
Other
Eligibility
21 Years and older
Enrollment
351 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 23, 2014 · Synced Oct 8, 2026, 9:53 PM EDT
Completed No phase listed Observational Results available

Safety and Performance of ENTACT Septal Staple System for Septoplasty

NCT04392583
View directory record Official record
Conditions
Septoplasty
Interventions
ENTACT Septal Staple system
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
3
States / cities
Boca Raton, Florida • Fort Lauderdale, Florida • Elkhart, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Oct 8, 2026, 9:53 PM EDT
Withdrawn Not applicable Interventional

Non-Comparative Study of Open Abdomen That Require the Use of Negative Pressure Wound Therapy (NPWT) for Temporary Abdominal Closure

NCT03431220
View directory record Official record
Conditions
Abdomenal Wound Trauma
Interventions
RENASYS® TOUCH Negative Pressure Wound Therapy (NPWT) Device
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 13, 2018 · Synced Oct 8, 2026, 9:53 PM EDT
Terminated Not applicable Interventional Results available

Mechanical vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage Lesions

NCT01803880
View directory record Official record
Conditions
Chondral Lesion Plus Partial Medial Meniscectomy
Interventions
Mechanical Debridement, RF-Based Debridement
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
7
States / cities
Tucson, Arizona • Gulf Breeze, Florida • Greenwood, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2019 · Synced Oct 8, 2026, 9:53 PM EDT
Active, not recruiting No phase listed Observational

Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts

NCT03687593
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Legion™ CR Oxinium and CoCr Femoral Implants combined with Legion™/Genesis™ II XLPE High Flex Tibial Inserts
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
4
States / cities
Edina, Minnesota • Reno, Nevada • Greenville, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 8, 2026, 9:53 PM EDT
Completed Not applicable Interventional Results available

Study of Suture Repair of Torn Meniscus in the Knee

NCT02237001
View directory record Official record
Conditions
Meniscal Tear, Meniscus Tear
Interventions
Suture-based meniscal repair
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
8
States / cities
Encinitas, California • Long Beach, California • Gulf Breeze, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2020 · Synced Oct 8, 2026, 9:53 PM EDT
Active, not recruiting No phase listed Observational

A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis

NCT05197036
View directory record Official record
Conditions
Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
Interventions
Total Knee Arthroplasty
Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2033
U.S. locations
12
States / cities
Atlanta, Georgia • Boston, Massachusetts • Novi, Michigan + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 8, 2026, 9:53 PM EDT
Recruiting No phase listed Observational

A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)

NCT07199738
View directory record Official record
Conditions
Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis), Post-traumatic Arthritis
Interventions
Cemented CoCr, Cemented Oxinium, Cementless
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2036
U.S. locations
4
States / cities
Newton, Massachusetts • New York, New York • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 8, 2026, 9:53 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Navio Robotic Versus Conventional Total Knee Arthroplasty

NCT03519269
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Navio™ Robotics-assisted Surgical System
Device
Lead sponsor
Columbia University
Other
Eligibility
40 Years to 85 Years
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 8, 2026, 9:53 PM EDT
Terminated No phase listed Observational

REDAPT Retrospective-Prospective Modular Stem Study

NCT02661620
View directory record Official record
Conditions
Arthroplasties, Hip Replacement
Interventions
REDAPT Revision Femoral System modular stem
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
3
States / cities
Louisville, Kentucky • Detroit, Michigan • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 8, 2026, 9:53 PM EDT
Completed No phase listed Observational

BIOSURE™ RG Knee Safety & Performance Study

NCT03519555
View directory record Official record
Conditions
ACL Repair, Posterior Cruciate Ligament (PCL) Repair, Medial Collateral Ligament (MCL), Lateral Collateral Ligament (LCL), Posterior Oblique Ligament (POL), Patellar Realignment and Tendon Repairs, Vastus Medialis Obliquus Advancement, Iliotibial Band Tenodesis, Extra-capsular Repairs, Knee Repair
Interventions
Not listed
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
3
States / cities
Rockford, Illinois • Charlotte, North Carolina • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 8, 2021 · Synced Oct 8, 2026, 9:53 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study

NCT03292003
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Journey II BCS Total Knee System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
1,694 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
9
States / cities
Aurora, Colorado • Gulf Breeze, Florida • Indianapolis, Indiana + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2019 · Synced Oct 8, 2026, 9:53 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Optimized Loading Response by JOURNEY II BCS Knee Increases Daily Physical Activity and Functions

NCT02335710
View directory record Official record
Conditions
Knee Injuries
Interventions
Journey II BCS TKA
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
40 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
3
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced Oct 8, 2026, 9:53 PM EDT
Completed Phase 3 Interventional Results available

Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers

NCT01656889
View directory record Official record
Conditions
Venous Leg Ulcers
Interventions
HP-802-247, Vehicle
Biological
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
447 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
45
States / cities
Glendale, Arizona • Phoenix, Arizona • Tucson, Arizona + 37 more
Source: ClinicalTrials.gov public record
Updated Mar 14, 2016 · Synced Oct 8, 2026, 9:53 PM EDT
Completed No phase listed Observational

VISIONAIRE™ Value Study

NCT01107769
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Not listed
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Lake Charles, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 21, 2011 · Synced Oct 8, 2026, 9:53 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

S&P of Q-Fix™ All-Suture Anchor System

NCT03594071
View directory record Official record
Conditions
Bankart Lesion, Acetabular Labrum Tear, SLAP Lesion, Acromioclavicular Sprain, Capsular Shift/Capsulolabral Reconstruction, Deltoid Repair, Rotator Cuff Repair, Bicep Tendinitis, Extra-capsular Repair, Medial Collateral Ligament, Lateal Collateral Ligament, Posterior Oblique Ligament, IBT, Vastus Medialis, Obliquus Advancement, Joint Capsule Closure
Interventions
The Q-Fix™ All-Suture Anchor
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
13 Years and older
Enrollment
294 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
5
States / cities
Washington D.C., District of Columbia • Chicago, Illinois • New Orleans, Louisiana + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 9, 2021 · Synced Oct 8, 2026, 9:53 PM EDT
Terminated Phase 3 Interventional Results available

Negative Pressure Wound Therapy: Are All Systems Alike?

NCT00590369
View directory record Official record
Conditions
Wounds
Interventions
KCI -VAC, Versatile One (EZCare)
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 2, 2012 · Synced Oct 8, 2026, 9:53 PM EDT
Active, not recruiting No phase listed Observational

JOURNEY II XR Safety and Effectiveness PMCF

NCT03136887
View directory record Official record
Conditions
Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee, Unilateral Post-Traumatic Osteoarthritis of Knee, Knee Osteoarthritis, Degenerative Arthritis Peripheral Joint, Failed Osteotomies, Failed Unicompartmental Replacement
Interventions
JOURNEY II XR Total Knee System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
22 Years to 75 Years
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2029
U.S. locations
14
States / cities
Loma Linda, California • Fort Lauderdale, Florida • Aurora, Illinois + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2024 · Synced Oct 8, 2026, 9:53 PM EDT
Enrolling by invitation No phase listed Observational

A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the Knee

NCT06916728
View directory record Official record
Conditions
Knee Injuries, Joint Surface Knee Lesions
Interventions
Marketed Product - MP01, Surgical Standard of Care
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
La Mesa, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 8, 2026, 9:53 PM EDT
Active, not recruiting Not applicable Interventional

Evaluation of Regeneten Augmentation for Subscapularis Healing After Total Shoulder Arthroplasty (RESTOR)

NCT04861714
View directory record Official record
Conditions
Arthroplasty, Replacement, Shoulder
Interventions
Regeneten, Standard repair
Device · Procedure
Lead sponsor
Ohio State University
Other
Eligibility
50 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 8, 2026, 9:53 PM EDT
Terminated No phase listed Observational Results available

Circumferential Compression STITCH Repairs of Complex and Horizontal Cleavage Meniscal Tears

NCT04361487
View directory record Official record
Conditions
Meniscus Tear, Retention; Meniscus
Interventions
NOVOSTITCH™ PRO Meniscal Repair System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
6
States / cities
Washington D.C., District of Columbia • Honolulu, Hawaii • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Oct 8, 2026, 9:53 PM EDT