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ClinicalTrials.gov public records Last synced Sep 1, 2026, 10:27 PM EDT

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Showing 1–24 of 30 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Aneurysm, Brain
Interventions
WAVE, as part of the SMART COIL System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years and older
Enrollment
572 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
34
States / cities
Dothan, Alabama • Tucson, Arizona • La Mesa, California + 29 more
Conditions
Stroke, Ischemic
Interventions
Penumbra System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years and older
Enrollment
650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
29
States / cities
Mesa, Arizona • Castro Valley, California • Fullerton, California + 25 more
Conditions
Acute Ischemic Stroke, Acute Ischemic Stroke (AIS) Related to a Distal Occlusion
Interventions
Endovascular Thrombectomy, Medical Management
Device · Other
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Knoxville, Tennessee
Conditions
Lower Extremity Acute Limb Ischemia, LE ALI
Interventions
Indigo Aspiration System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years and older
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
14
States / cities
Stanford, California • Danbury, Connecticut • Bradenton, Florida + 11 more
Conditions
Wide-neck, Saccular Intracranial Aneurysms
Interventions
Stent assisted coiling with the Liberty Stent
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
3
States / cities
Denver, Colorado • Chicago, Illinois • Stony Brook, New York
Conditions
Stroke
Interventions
Penumbra System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years to 79 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Kansas City, Missouri
Completed Not applicable Interventional Results available

MIND: Artemis in the Removal of Intracerebral Hemorrhage

NCT03342664
Conditions
Cerebral Hemorrhage, Brain Hemorrhage, Cerebral Parenchymal Hemorrhage, Intracerebral Hemorrhage
Interventions
Artemis + Medical Management, Best Medical Management Alone (MM)
Device · Other
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
27
States / cities
Phoenix, Arizona • Los Angeles, California • Mission Viejo, California + 22 more
Conditions
Stroke
Interventions
Current standard of care for acute ischemic stroke other than IV rtPA or other IA therapies
Other
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years to 85 Years · Male only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Plano, Texas
Conditions
Deep Vein Thrombosis, DVT
Interventions
Indigo Aspiration System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years and older
Enrollment
229 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
42
States / cities
La Mesa, California • Long Beach, California • Los Angeles, California + 32 more
Completed Not applicable Interventional Results available

Study of the Penumbra Coil 400 System to Treat Aneurysm

NCT01465841
Conditions
Intracranial Aneurysms, Peripheral Aneurysms
Interventions
PC 400 coils (Penumbra )
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
Not listed
Enrollment
517 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
6
States / cities
Newport Beach, California • Chicago, Illinois • New York, New York + 3 more
Conditions
Stroke, Ischemic
Interventions
Penumbra System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Englewood, Colorado • Tampa, Florida
Conditions
Intracranial Aneurysm
Interventions
Penumbra Smart Coil, Penumbra Coil 400TM (PC400), Penumbra Occlusion DeviceTM(POD)
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
Not listed
Enrollment
995 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
71
States / cities
Dothan, Alabama • Mesa, Arizona • Phoenix, Arizona + 62 more
Conditions
Acute Deep Vein Thrombosis
Interventions
Thrombolysis in combination with endhole aspiration
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Kansas City, Kansas
Conditions
Coronary Vessel Occlusion
Interventions
Indigo Aspiration System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
25
States / cities
Los Angeles, California • Orange, California • San Diego, California + 21 more
Conditions
Acute Ischemic Stroke
Interventions
Penumbra System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Lower Extremity Acute Limb Ischemia, LE ALI
Interventions
Indigo Aspiration System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
35
States / cities
Scottsdale, Arizona • San Diego, California • Ventura, California + 31 more
Conditions
Chronic Pelvic Pain Syndrome, Pelvic Pain, Pelvic Varices, Pelvic Congestive Syndrome, Pelvic Pain Syndrome
Interventions
Transcatheter Venography, Bilateral ovarian vein embolization
Diagnostic Test · Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
4
States / cities
New Hyde Park, New York • New York, New York • Chapel Hill, North Carolina + 1 more
Conditions
Peripheral Arterial Occlusion or Emboli
Interventions
Mechanical Thrombectomy by the Indigo System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
Not listed
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
5
States / cities
San Diego, California • Miami, Florida • Chicago, Illinois + 2 more
Conditions
Ischemic Stroke
Interventions
intravenous (IV) recombinant human tissue plasminogen activator (rtPA), Penumbra System
Drug · Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
4
States / cities
Denver, Colorado • Gainesville, Florida • Chicago, Illinois + 1 more
Conditions
Stroke
Interventions
Penumbra System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
Not listed
Enrollment
289 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Englewood, Colorado
Completed No phase listed Observational Results available

Investigation of Clot in Ischemic Stroke and Hematoma Evacuation

NCT04693767
Conditions
Ischemic Stroke, Intracranial Hematoma
Interventions
Mechanical thrombectomy, Minimally invasive surgery
Device · Other
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
27
States / cities
Mesa, Arizona • Phoenix, Arizona • Newark, Delaware + 24 more
Conditions
Visceral Artery Aneurysms, Arteriovenous Malformations
Interventions
Penumbra Ruby Coil System
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Conditions
Intracranial Aneurysms
Interventions
PC 400
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
Not listed
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Bellevue, Washington
Completed Not applicable Interventional Results available

Comparison of Two Pulmonary Embolism Treatments

NCT05684796
Conditions
Pulmonary Embolism Acute
Interventions
Anticoagulation, mechanical aspiration thrombectomy
Drug · Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
19
States / cities
Tucson, Arizona • Los Angeles, California • Lakeland, Florida + 14 more