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ClinicalTrials.gov public records Last synced Oct 1, 2026, 5:32 PM EDT

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Showing 1–24 of 1,120 matching trials from the live ClinicalTrials.gov search.
Filters: Sponsor: The Cleveland Clinic Clear all
Recruiting No phase listed Observational Accepts healthy volunteers

Analysis of Anterior Chamber Inflammation by Optical Coherence Tomography

NCT01746537
View directory record Official record
Conditions
Uveitis
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
Not listed
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2029
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Oct 1, 2026, 5:32 PM EDT
Completed Phase 3 Interventional

The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection

NCT00273377
View directory record Official record
Conditions
Surgical Wound Infection, Surgery, Colon
Interventions
Mild intraoperative hypercapnia (50 mmHg vs. 30 mmHg), Supplemental oxygen (80% vs. 30%), Dexamethasone, Placebo
Other · Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
2
States / cities
Louisville, Kentucky • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 29, 2016 · Synced Oct 1, 2026, 5:32 PM EDT
Completed No phase listed Observational

Genomic Sequencing in Patients With HCM Undergoing Septal Myectomy

NCT03043209
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy, Genetic Disease, Gene Product Sequence Variation
Interventions
Genomic sequencing
Genetic
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 6, 2023 · Synced Oct 1, 2026, 5:32 PM EDT
Withdrawn Not applicable Interventional

Brain Autoregulation Research Study

NCT07221721
View directory record Official record
Conditions
Hypotension During Surgery, Hypotension Postprocedural
Interventions
Surgery with Active MAP Management, Surgery without Active MAP Management
Device · Other
Lead sponsor
Jennie E Minnich
Other
Eligibility
30 Days to 30 Days
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Oct 1, 2026, 5:32 PM EDT
Completed No phase listed Observational

Quantitative Detection of Circulating Donor-Specific DNA in Organ Transplant Recipients (DTRT-Multi-Center Study)

NCT02109575
View directory record Official record
Conditions
Cardiovascular Disease, Acute Rejection of Cardiac Transplant, Cardiac Transplant Rejection, Heart Transplant Failure and Rejection
Interventions
Blood Draw of up to 10 ml
Diagnostic Test
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
Not listed
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
8
States / cities
Little Rock, Arkansas • Atlanta, Georgia • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2021 · Synced Oct 1, 2026, 5:32 PM EDT
Recruiting Phase 2 Interventional

Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS

NCT07442747
View directory record Official record
Conditions
Parkinson's Disease, Deep Brain Stimulation
Interventions
Exercise
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 1, 2026, 5:32 PM EDT
Terminated Not applicable Interventional Results available

Improving Erectile Function and Quality of Life After Prostate Cancer Treatment

NCT01996852
View directory record Official record
Conditions
Prostate Cancer, Erectile Dysfunction Following Radical Prostatectomy, Erectile Dysfunction Following Simple Prostatectomy, Erectile Dysfunction
Interventions
Cognitive-behavioral Meetings, sildenafil citrate, Vacuum Constriction Device
Behavioral · Drug · Device
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
21 Years and older · Male only
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 10, 2019 · Synced Oct 1, 2026, 5:32 PM EDT
Completed No phase listed Observational

Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19

NCT04343898
View directory record Official record
Conditions
Coronavirus Infection
Interventions
No intervention
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
5,154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 9, 2023 · Synced Oct 1, 2026, 5:32 PM EDT
Completed No phase listed Observational

Invasive Approach to Model Human Cortex-Basal Ganglia Action-Regulating Networks

NCT03608228
View directory record Official record
Conditions
Parkinson's Disease Patients Undergoing Deep Brain Stimulation (DBS) Surgery
Interventions
Measuring electrical signals from the brain
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2021 · Synced Oct 1, 2026, 5:32 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

HA35 Acute Alcohol Study

NCT05025865
View directory record Official record
Conditions
Healthy Controls
Interventions
Sodium Hyaluronate, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
21 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 1, 2026, 5:32 PM EDT
Terminated Phase 4 Interventional Results available

Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients

NCT02200328
View directory record Official record
Conditions
Clostridium Difficile Diarrhea
Interventions
Metronidazole, Placebo
Drug
Lead sponsor
Alison Schneider
Other
Eligibility
55 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Weston, Florida
Source: ClinicalTrials.gov public record
Updated May 17, 2017 · Synced Oct 1, 2026, 5:32 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)

NCT02016430
View directory record Official record
Conditions
Dietary Modification, Cardiovascular Risk Factor
Interventions
MeLT Dietary intervention, TLC Dietary intervention, MeLT dietary intervention with TMAO
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 1, 2026, 5:32 PM EDT
Recruiting Not applicable Interventional

Intracardiac Echocardiography Guided Watchman Device Implant

NCT06007872
View directory record Official record
Conditions
Atrial Fibrillation, Left Atrial Appendage Thrombosis
Interventions
Intracardiac Echocardiography (ICE)
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Oct 1, 2026, 5:32 PM EDT
Completed Not applicable Interventional

Coronavirus 2019 (COVID-19)- Using Ascorbic Acid and Zinc Supplementation

NCT04342728
View directory record Official record
Conditions
COVID, Corona Virus Infection
Interventions
Ascorbic Acid, Zinc Gluconate, Ascorbic Acid and Zinc Gluconate, Standard of Care
Dietary Supplement · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
214 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Weston, Florida • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Oct 1, 2026, 5:32 PM EDT
Completed No phase listed Observational

Pomalidomide for the Treatment of Bleeding in Hereditary Hemorrhagic Telangiectasia Longitudinal Assessment Study

NCT07018401
View directory record Official record
Conditions
Hereditary Hemorrhagic Telangiectasia (HHT)
Interventions
Pomalidomide
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
Not listed
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
11
States / cities
San Diego, California • San Francisco, California • Gainesville, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 1, 2026, 5:32 PM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

NCT03295981
View directory record Official record
Conditions
Giant Cell Tumor of Bone
Interventions
Zoledronic Acid
Drug
Lead sponsor
St. Louis University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2028
U.S. locations
14
States / cities
Los Angeles, California • Indianapolis, Indiana • Iowa City, Iowa + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 1, 2026, 5:32 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age

NCT05345457
View directory record Official record
Conditions
Pregnancy Preterm, Pregnancy Prom, PROM, Preterm (Pregnancy), PROM (Pregnancy), Premat Rupture Membranes Preterm Unspec to Length of Time Between Rupture/Labor, Premature Birth
Interventions
Azithromycin Pill, Amoxicillin Pill
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
3
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 1, 2026, 5:32 PM EDT
Withdrawn Not applicable Interventional

CirQPOD Shoulder Study

NCT04299776
View directory record Official record
Conditions
Hypotension on Induction
Interventions
CirQPOD, Standard airway management
Device
Lead sponsor
Zoll Medical Corporation
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Oct 1, 2026, 5:32 PM EDT
Active, not recruiting Not applicable Interventional

Randomized Controlled Trial of Digital Twin Precision Treatment: A Novel Whole Body Digital Twin Enabled Precision Treatment for Type 2 Diabetes

NCT05181449
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Twin Precision Treatment
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Twinsburg, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Oct 1, 2026, 5:32 PM EDT
Completed Not applicable Interventional

Comparing the Efficacy of Epidural and Quadratus Lumborum Analgesia After Open Nephrectomy Surgery

NCT03110081
View directory record Official record
Conditions
Open Nephrectomy Surgery
Interventions
Quadratus lumborum block, Epidural analgesia
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
Not listed
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 29, 2021 · Synced Oct 1, 2026, 5:32 PM EDT
Completed Not applicable Interventional

Impact of Perioperative Intravenous Fluid Utilization on Postoperative Outcomes

NCT01563991
View directory record Official record
Conditions
Benign Neoplasm of Intestinal Tract, Primary Malignant Neoplasm of Intestinal Tract, Secondary Malignant Neoplasm of Intestinal Tract
Interventions
Normal fluid volume, Reduced fluid volume
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Oct 1, 2026, 5:32 PM EDT
Completed Phase 2 Interventional Results available

Bexarotene Amyloid Treatment for Alzheimer's Disease

NCT01782742
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
Bexarotene, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
50 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Feb 12, 2016 · Synced Oct 1, 2026, 5:32 PM EDT
Recruiting Early Phase 1 Interventional

Self-Start Triage Model for Post-Botox® Lower Urinary Tract Symptoms

NCT07648290
View directory record Official record
Conditions
Overactive Bladder
Interventions
Macrobid® Capsules 100 mg, Standard Medical Care (SMC)
Drug · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 1, 2026, 5:32 PM EDT
Completed Not applicable Interventional

Improving ACL Reconstruction Outcomes: CBPT

NCT03243162
View directory record Official record
Conditions
ACL Injury, ACL - Anterior Cruciate Ligament Rupture, ACL Sprain, ACL Tear
Interventions
CBPT-ACLR, Education
Behavioral · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
14 Years to 35 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Garfield Heights, Ohio • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 20, 2020 · Synced Oct 1, 2026, 5:32 PM EDT