ClinicalTrials.gov record
Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer
ClinicalTrials.gov ID: NCT00003139
Public ClinicalTrials.gov record NCT00003139. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 5, 2026, 11:48 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Study to Test the Efficacy of the Prophylactic Use of Oral Pilocarpine to Reduce Hyposalivation and Mucositis Associated With Curative Radiation Therapy in Head and Neck Cancer Patients
Study identification
- NCT ID
- NCT00003139
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Radiation Therapy Oncology Group
- Network
- Enrollment
- 249 participants
Conditions and interventions
Conditions
Interventions
- Placebo Other
- pilocarpine hydrochloride Drug
Other · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 120 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 28, 1998
- Primary completion
- Dec 31, 2000
- Completion
- Sep 30, 2002
- Last update posted
- Nov 16, 2015
1998 – 2002
United States locations
- U.S. sites
- 216
- U.S. states
- 43
- U.S. cities
- 169
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Veterans Affairs Medical Center - Birmingham | Birmingham | Alabama | 35233 | — |
| University of Alabama Comprehensive Cancer Center | Birmingham | Alabama | 35294 | — |
| Huntsville Hospital System | Huntsville | Alabama | 35801 | — |
| Urology Associates - Mobile AL | Mobile | Alabama | 36640 | — |
| MBCCOP - University of South Alabama | Mobile | Alabama | 36688 | — |
| Alabama Oncology, LLC | Montgomery | Alabama | 36106-2801 | — |
| Radiation Oncology Associates of West Alabama | Tuscallosa | Alabama | 35401 | — |
| Providence Cancer Therapy Center | Anchorage | Alaska | 99508 | — |
| Arizona Cancer Center | Tucson | Arizona | 85724 | — |
| Providence Saint Joseph Medical Center - Burbank | Burbank | California | 91505 | — |
| Mount Diablo Medical Center | Concord | California | 94524-4110 | — |
| Beckman Research Institute, City of Hope | Duarte | California | 91010 | — |
| California Cancer Center | Fresno | California | 93720 | — |
| Saint Agnes Cancer Center | Fresno | California | 93720 | — |
| Glendale Memorial Hospital and Health Center | Glendale | California | 91204 | — |
| Sutter Health Western Division Cancer Research Group | Greenbrae | California | 94904 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| Veterans Affairs Medical Center - Long Beach | Long Beach | California | 90822 | — |
| Kaiser Permanente Medical Center - Los Angeles | Los Angeles | California | 90027 | — |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033-0800 | — |
| Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | 90095-1781 | — |
| Veterans Affairs Outpatient Clinic - Martinez | Martinez | California | 94553 | — |
| CCOP - Bay Area Tumor Institute | Oakland | California | 94609-3305 | — |
| Cancer Care Center | Pomona | California | 91767 | — |
| Mercy Medical Center - Redding | Redding | California | 96099-6009 | — |
| Radiation Oncology Center - Sacramento | Sacramento | California | 95816 | — |
| UCSF Cancer Center and Cancer Research Institute | San Francisco | California | 94115-0128 | — |
| Santa Cruz Radiation Oncology Medical Group, Inc. | Santa Cruz | California | 95065 | — |
| CCOP - Santa Rosa Memorial Hospital | Santa Rosa | California | 95403 | — |
| Stanford University | Stanford | California | 94305 | — |
| David Grant Medical Center | Travis Air Force Base | California | 94535 | — |
| Radiation Oncology Center - Walnut Creek | Walnut Creek | California | 94598 | — |
| Memorial Hospital Cancer Center | Colorado Springs | Colorado | 80909 | — |
| University of Colorado Cancer Center | Denver | Colorado | 80262 | — |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | — |
| Whittingham Cancer Center | Norwalk | Connecticut | 06856 | — |
| CCOP - Christiana Care Health Services | Wilmington | Delaware | 19899 | — |
| Walter Reed Army Medical Center | Washington D.C. | District of Columbia | 20307-5000 | — |
| Lykes Center for Radiation Therapy | Clearwater | Florida | 33757-0210 | — |
| Halifax Medical Center | Daytona Beach | Florida | 32114 | — |
| Radiation Therapy Associates - Fort Myers | Fort Myers | Florida | 33901 | — |
| University of Florida Health Science Center | Gainesville | Florida | 32610-0296 | — |
| Health First Holmes Regional Medical Center | Melbourne | Florida | 32901 | — |
| Sylvester Cancer Center, University of Miami | Miami | Florida | 33136 | — |
| Baptist Hospital of Miami | Miami | Florida | 33176-2197 | — |
| CCOP - Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| Florida Radiation Oncology Group | Orange Park | Florida | 32073 | — |
| MD Anderson Cancer Center Orlando | Orlando | Florida | 32806 | — |
| Gulf Coast Cancer Treatment Center | Panama City | Florida | 32405-4587 | — |
| West Florida Cancer Institute - Pensacola | Pensacola | Florida | 32514 | — |
| Bayfront Medical Center | St. Petersburg | Florida | 33701 | — |
| H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | 33612 | — |
| Emory University Hospital - Atlanta | Atlanta | Georgia | 30322 | — |
| CCOP - Atlanta Regional | Atlanta | Georgia | 30342-1701 | — |
| InterCommunity Cancer Center at Rome | Rome | Georgia | 30161 | — |
| South Georgia Medical Center | Valdosta | Georgia | 31603 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| University of Chicago Cancer Research Center | Chicago | Illinois | 60637 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Lutheran General Cancer Care Center | Park Ridge | Illinois | 60068 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| CCOP - Central Illinois | Springfield | Illinois | 62526 | — |
| CCOP - Carle Cancer Center | Urbana | Illinois | 61801 | — |
| St. John's Medical Center | Anderson | Indiana | 46016 | — |
| Clarion Health Partners Inc. | Indianapolis | Indiana | 46206-1367 | — |
| Community Hospitals of Indianapolis - Regional Cancer Center | Indianapolis | Indiana | 46219 | — |
| Ball Memorial Hospital | Muncie | Indiana | 47303-3499 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| St. Joseph's Radiation Oncology Center | South Bend | Indiana | 46617 | — |
| Wendt Regional Cancer Center of Finley Hospital | Dubuque | Iowa | 52001 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Medical Center at Bowling Green | Bowling Green | Kentucky | 42102 | — |
| Veterans Affairs Medical Center - Lexington | Lexington | Kentucky | 40511-1093 | — |
| Albert B. Chandler Medical Center, University of Kentucky | Lexington | Kentucky | 40536-0084 | — |
| James Graham Brown Cancer Center | Louisville | Kentucky | 40202 | — |
| Louisville Radiation Oncology | Louisville | Kentucky | 40215 | — |
| Merle M. Mahr Cancer Center | Madisonville | Kentucky | 42431 | — |
| Western Baptist Hospital | Paducah | Kentucky | 42001 | — |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | — |
| Romagosa Radiation Oncology Center | Lafayette | Louisiana | 70501 | — |
| East Jefferson General Hospital | Metairie | Louisiana | 70011 | — |
| MBCCOP - LSU Medical Center | New Orleans | Louisiana | 70112 | — |
| CCOP - Ochsner | New Orleans | Louisiana | 70121 | — |
| Maine Medical Center | Portland | Maine | 04102 | — |
| Anne Arundel Oncology Center | Annapolis | Maryland | 21401 | — |
| Marlene & Stewart Greenebaum Cancer Center, University of Maryland | Baltimore | Maryland | 21201 | — |
| Greater Baltimore Medical Center and Cancer Center | Baltimore | Maryland | 21204 | — |
| Harbor Hospital Center | Baltimore | Maryland | 21225 | — |
| Radiation Oncology Affiliates of Maryland, P.A. | Baltimore | Maryland | 21237 | — |
| Johns Hopkins Oncology Center | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| Joint Center for Radiation Therapy | Boston | Massachusetts | 02215 | — |
| Cape Cod Hospital | Hyannis | Massachusetts | 02601 | — |
| Veterans Affairs Medical Center - Ann Arbor | Ann Arbor | Michigan | 48105 | — |
| CCOP - Ann Arbor Regional | Ann Arbor | Michigan | 48106 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109-0752 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| CCOP - Kalamazoo | Kalamazoo | Michigan | 49007-3731 | — |
| Marquette General Hospital | Marquette | Michigan | 49855 | — |
| St. Mary's Medical Center | Saginaw | Michigan | 48601 | — |
| Mayo Clinic Cancer Center | Rochester | Minnesota | 55905 | — |
| CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Ellis Fischel Cancer Center - Columbia | Columbia | Missouri | 65203 | — |
| CCOP - Kansas City | Kansas City | Missouri | 64131 | — |
| Cancer Research for the Ozarks | Springfield | Missouri | 65807 | — |
| CCOP - Ozarks Regional | Springfield | Missouri | 65807 | — |
| Veterans Affairs Medical Center - Saint Louis | St Louis | Missouri | 63106 | — |
| St. Louis University Health Sciences Center | St Louis | Missouri | 63110-0250 | — |
| Mallinckrodt Institute of Radiology | St Louis | Missouri | 63110 | — |
| CCOP - Montana Cancer Consortium | Billings | Montana | 59101 | — |
| Methodist Cancer Center - Omaha | Omaha | Nebraska | 68114 | — |
| CCOP - Missouri Valley Cancer Consortium | Omaha | Nebraska | 68131 | — |
| CCOP - Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | 89106 | — |
| Norris Cotton Cancer Center | Lebanon | New Hampshire | 03756 | — |
| Elliot Regional Cancer Center | Manchester | New Hampshire | 03103 | — |
| Veterans Affairs Medical Center - East Orange | East Orange | New Jersey | 07018-1095 | — |
| John F. Kennedy Medical Center | Edison | New Jersey | 08818 | — |
| Elizabeth General Medical Center - West | Elizabeth | New Jersey | 07201 | — |
| South Jersey Hospital - Millville | Millville | New Jersey | 08332 | — |
| Fox Chase Cancer Center at Virtua-Memorial Hospital Burlington County | Mount Holly | New Jersey | 08060 | — |
| Community Medical Center | Toms River | New Jersey | 08755 | — |
| St. Francis Medical Center | Trenton | New Jersey | 08629 | — |
| Saint Joseph Medical Center | Albuquerque | New Mexico | 87102 | — |
| Cancer Center of Albany Medical Center | Albany | New York | 12208 | — |
| Veterans Affairs Medical Center - Albany | Albany | New York | 12208 | — |
| State University of New York Health Science Center at Brooklyn | Brooklyn | New York | 11203 | — |
| New York Methodist Hospital | Brooklyn | New York | 11215-3609 | — |
| CCOP - North Shore University Hospital | Manhasset | New York | 11030 | — |
| Kaplan Cancer Center | New York | New York | 10016 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10021 | — |
| Champlain Valley Physicians Hospital Medical Center | Plattsburgh | New York | 12901 | — |
| Vassar Brothers Hospital | Poughkeepsie | New York | 12601 | — |
| Genesee Hospital - Rochester | Rochester | New York | 14607 | — |
| University of Rochester Cancer Center | Rochester | New York | 14642 | — |
| Albert Einstein Comprehensive Cancer Center | The Bronx | New York | 10461 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| Lineberger Comprehensive Cancer Center, UNC | Chapel Hill | North Carolina | 27599-7295 | — |
| East Carolina University School of Medicine | Greenville | North Carolina | 27858-4354 | — |
| CCOP - Southeast Cancer Control Consortium | Winston-Salem | North Carolina | 27104-4241 | — |
| Comprehensive Cancer Center of Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157-1082 | — |
| Meritcare Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| UNI-MED Medical Center | Minot | North Dakota | 58701 | — |
| Akron General Medical Center | Akron | Ohio | 44302 | — |
| Akron City Hospital | Akron | Ohio | 44309 | — |
| Christ Hospital | Cincinnati | Ohio | 45219 | — |
| Ireland Cancer Center | Cleveland | Ohio | 44106-5065 | — |
| CCOP - Columbus | Columbus | Ohio | 43206 | — |
| Arthur G. James Cancer Hospital - Ohio State University | Columbus | Ohio | 43210 | — |
| Veterans Affairs Medical Center - Dayton | Dayton | Ohio | 45428 | — |
| CCOP - Dayton | Kettering | Ohio | 45429 | — |
| CCOP - Toledo Community Hospital Oncology Program | Toledo | Ohio | 43623-3456 | — |
| St. John Medical Center | Tulsa | Oklahoma | 74104 | — |
| Samaritan Regional Cancer Center | Corvallis | Oregon | 97339 | — |
| CCOP - Columbia River Program | Portland | Oregon | 97213 | — |
| Penn State Geisinger Medical Center | Danville | Pennsylvania | 17822-2001 | — |
| Mercy Catholic Medical Center, Mercy Fitzgerald Divison | Darby | Pennsylvania | 19023 | — |
| Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | 19026 | — |
| Penn State Geisinger Cancer Center | Hershey | Pennsylvania | 17033 | — |
| Allegheny University Hospitals- Hahnemann | Philadelphia | Pennsylvania | 19102-1192 | — |
| University of Pennsylvania Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| Veterans Affairs Medical Center - Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Kimmel Cancer Center of Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | 19107 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Albert Einstein Cancer Center | Philadelphia | Pennsylvania | 19141 | — |
| University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | 15213 | — |
| Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| Reading Hospital and Medical Center | Reading | Pennsylvania | 19612-6052 | — |
| Mercy Hospital Cancer Center - Scranton | Scranton | Pennsylvania | 18501 | — |
| Grand View Hospital | Sellersville | Pennsylvania | 18960 | — |
| Wilkes Barre General Hospital | Wilkes-Barre | Pennsylvania | 18764 | — |
| CCOP - MainLine Health | Wynnewood | Pennsylvania | 19096 | — |
| York Hospital | York | Pennsylvania | 17315 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425-0721 | — |
| CCOP - Greenville | Greenville | South Carolina | 29615 | — |
| CCOP - Upstate Carolina | Spartanburg | South Carolina | 29303 | — |
| Jackson-Madison County General Hospital | Jackson | Tennessee | 38301 | — |
| Baptist Regional Cancer Center - Knoxville | Knoxville | Tennessee | 37901 | — |
| CCOP - Baptist Cancer Institute | Memphis | Tennessee | 38117 | — |
| University of Tennessee, Memphis Cancer Center | Memphis | Tennessee | 38163 | — |
| Vanderbilt Cancer Center | Nashville | Tennessee | 37232-6838 | — |
| Julie and Ben Rogers Cancer Institute | Beaumont | Texas | 77701 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555-1329 | — |
| University of Texas - MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Wilford Hall - 59th Medical Wing | Lackland Air Force Base | Texas | 78236-5300 | — |
| Bayshore Medical Center | Pasadena | Texas | 77504 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Dixie Regional Medical Center | St. George | Utah | 84770 | — |
| CCOP - Southwestern Vermont Regional Cancer Center | Bennington | Vermont | 05201 | — |
| Green Mountain Oncology Group | Rutland | Vermont | 05701 | — |
| Veterans Affairs Medical Center - White River Junction | White River Junction | Vermont | 05009 | — |
| Martha Jefferson Hospital | Charlottesville | Virginia | 22901 | — |
| Cancer Center, University of Virginia HSC | Charlottesville | Virginia | 22908 | — |
| Virginia Baptist Hospital | Lynchburg | Virginia | 24503 | — |
| Naval Medical Center, Portsmouth | Portsmouth | Virginia | 23708-2197 | — |
| Massey Cancer Center | Richmond | Virginia | 23298-0037 | — |
| Swedish Hospital Tumor Institute | Seattle | Washington | 98104 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98111 | — |
| Deaconess Medical Center | Spokane | Washington | 99210-0248 | — |
| Yakima Valley Memorial Hospital | Yakima | Washington | 98902 | — |
| Schiffler Oncology Center | Wheeling | West Virginia | 26003 | — |
| St. Vincent Hospital | Green Bay | Wisconsin | 54307-3508 | — |
| Gundersen Lutheran Medical Foundation | La Crosse | Wisconsin | 54601 | — |
| Veterans Affairs Medical Center - Madison | Madison | Wisconsin | 53705 | — |
| Southern Wisconsin Radiotherapy Center | Madison | Wisconsin | 53713 | — |
| University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | 53792 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
| Community Memorial Hospital | Menomonee Falls | Wisconsin | 53051 | — |
| St. Joseph's Hospital | Milwaukee | Wisconsin | 53210 | — |
| Columbia Hospital | Milwaukee | Wisconsin | 53211 | — |
| St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Veterans Affairs Medical Center - Milwaukee (Zablocki) | Milwaukee | Wisconsin | 53295 | — |
| Southeastern Wisconsin Regional Cancer Center | Racine | Wisconsin | 53405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00003139, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 16, 2015 · Synced May 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00003139 live on ClinicalTrials.gov.