ClinicalTrials.gov record
Chemotherapy and Radiation Therapy With or Without Surgery in Treating Patients With Head and Neck Cancer
ClinicalTrials.gov ID: NCT00047008
Public ClinicalTrials.gov record NCT00047008. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Trial of Concurrent Radiation and Chemotherapy for Advanced Head and Neck Carcinomas
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Radiation therapy (RT) uses high-energy x-rays to damage tumor cells. Giving radiation therapy in different ways and combining it with chemotherapy before surgery may kill more tumor cells. It is not yet known which radiation therapy regimen combined with chemotherapy with or without surgery is more effective for head and neck cancer. PURPOSE: Randomized phase III trial to compare two different radiation therapy regimens combined with cisplatin with or without surgery in treating patients who have stage III or stage IV head and neck cancer.
Study identification
- NCT ID
- NCT00047008
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 743 participants
Conditions and interventions
Conditions
Interventions
- cisplatin Drug
- Standard fractionation RT Radiation
- Accelerated fractionation radiation therapy Radiation
- Conventional surgery for select patients Procedure
Drug · Radiation · Procedure
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2002 (Actual)
- Primary completion
- Jun 2010 (Actual)
- Completion
- May 20, 2022 (Actual)
- Last update posted
- Jul 7, 2023
2002 – 2022
United States locations
- U.S. sites
- 195
- U.S. states
- 38
- U.S. cities
- 146
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Comprehensive Cancer Center at University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Mobile Infirmary Medical Center | Mobile | Alabama | 36607 | — |
| Foundation for Cancer Research and Education | Phoenix | Arizona | 85013 | — |
| CCOP - Mayo Clinic Scottsdale Oncology Program | Scottsdale | Arizona | 85259 | — |
| Scottsdale Healthcare - Shea | Scottsdale | Arizona | 85260 | — |
| Virginia G. Piper Cancer Center at Scottsdale Healthcare - Osborn | Scottsdale | Arizona | 85260 | — |
| Providence Saint Joseph Medical Center - Burbank | Burbank | California | 91505 | — |
| Saint Rose Hospital | Hayward | California | 94545 | — |
| Cancer Care Consultants Medical Associates at Daniel Freeman Memorial Hospital | Inglewood | California | 90301 | — |
| Valley Memorial Hospital | Livermore | California | 94550 | — |
| Loma Linda University Cancer Institute at Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| USC/Norris Comprehensive Cancer Center and Hospital | Los Angeles | California | 90033-0804 | — |
| Providence Holy Cross Cancer Center | Mission Hills | California | 91346-9600 | — |
| Highland General Hospital | Oakland | California | 94602 | — |
| CCOP - Bay Area Tumor Institute | Oakland | California | 94609 | — |
| Summit Medical Center | Oakland | California | 94609 | — |
| Pomona Valley Hospital Medical Center | Pomona | California | 91767 | — |
| Radiological Associates of Sacramento Medical Group, Inc. | Sacramento | California | 95815 | — |
| University of California Davis Cancer Center | Sacramento | California | 95817 | — |
| Naval Medical Center - San Diego | San Diego | California | 92134 | — |
| J.C. Robinson, M.D. Regional Cancer Center | San Pablo | California | 94806 | — |
| Memorial Hospital Cancer Center | Colorado Springs | Colorado | 80909 | — |
| University of Colorado Cancer Center at University of Colorado Health Sciences Center | Denver | Colorado | 80217-3364 | — |
| Beebe Medical Center | Lewes | Delaware | 19958 | — |
| CCOP - Christiana Care Health Services | Newark | Delaware | 19718 | — |
| St. Francis Hospital | Wilmington | Delaware | 19805 | — |
| Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | — |
| 21st Century Oncology - Fort Myers | Fort Myers | Florida | 33901 | — |
| Shands Cancer Center at the University of Florida - Jacksonville | Gainesville | Florida | 32610 | — |
| Memorial Cancer Institute at Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Baptist Cancer Institute - Jacksonville | Jacksonville | Florida | 32207 | — |
| University of Florida Shands Cancer Center | Jacksonville | Florida | 32209 | — |
| Ella Milbank Foshay Cancer Center at Jupiter Medical Center | Jupiter | Florida | 33458 | — |
| CCOP - Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| Gulf Coast Cancer Treatment Center | Panama City | Florida | 32405 | — |
| H. Lee Moffitt Cancer Center and Research Institute at University of South Florida | Tampa | Florida | 33612 | — |
| Georgia Cancer Center for Excellence at Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Emory University Hospital - Atlanta | Atlanta | Georgia | 30322 | — |
| John B. Amos Community Cancer Center | Columbus | Georgia | 31904 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | Savannah | Georgia | 31403 | — |
| Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | Boise | Idaho | 83706 | — |
| Northwest Community Hospital | Arlington Heights | Illinois | 60005 | — |
| Mount Sinai Hospital Medical Center | Chicago | Illinois | 60608 | — |
| Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago | Illinois | 60611 | — |
| Creticos Cancer Center at Advocate Illinois Masonic Medical Center | Chicago | Illinois | 60657 | — |
| Cancer Care Center at Advocate Good Samaritan Hospital | Downers Grove | Illinois | 60515 | — |
| Alexian Brothers Cancer Care Center | Elk Grove Village | Illinois | 60007 | — |
| Ingalls Cancer Care Center at Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| St. John's Cancer Center at St. John's Medical Center | Anderson | Indiana | 46016 | — |
| St. Francis Hospital and Health Centers | Beech Grove | Indiana | 46107 | — |
| Elkhart General Hospital | Elkhart | Indiana | 46515 | — |
| Indiana University Cancer Center | Indianapolis | Indiana | 46202 | — |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte | Indiana | 46350 | — |
| Saint Joseph Regional Medical Center - Plymouth Campus | Plymouth | Indiana | 46544 | — |
| CCOP - Northern Indiana CR Consortium | South Bend | Indiana | 46601 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| Wendt Regional Cancer Center at Finley Hospital | Dubuque | Iowa | 52001 | — |
| Cancer Treatment Center at the Medical Center - Bowling Green | Bowling Green | Kentucky | 42101 | — |
| Markey Cancer Center at University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536 | — |
| James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | 40202 | — |
| Baton Rouge General Regional Cancer Center | Baton Rouge | Louisiana | 70806 | — |
| Mary Bird Perkins Cancer Center - Baton Rouge | Baton Rouge | Louisiana | 70809 | — |
| Cancer Center at Medical Center of Louisiana - New Orleans | New Orleans | Louisiana | 70112 | — |
| MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Tulane Cancer Center | New Orleans | Louisiana | 70112 | — |
| New Orleans Cancer Institute at Memorial Medical Center | New Orleans | Louisiana | 70115 | — |
| DeCesaris Cancer Institute at Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| Union Hospital Cancer Center at Union Hospital | Elkton | Maryland | 21921 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| Cancer Research Center at Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Hudner Oncology Center at Saint Anne's Hospital | Fall River | Massachusetts | 02721 | — |
| Cape Cod Hospital | Hyannis | Massachusetts | 02601 | — |
| South Suburban Oncology Center | Quincy | Massachusetts | 02169 | — |
| CCOP - Michigan Cancer Research Consortium | Ann Arbor | Michigan | 48100 | — |
| St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital | Ann Arbor | Michigan | 48106-0995 | — |
| Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn | Michigan | 48123 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201-1379 | — |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | Detroit | Michigan | 48236 | — |
| Hurley Medical Center | Flint | Michigan | 48502 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48532 | — |
| Great Lakes Cancer Institute at McLaren Regional Medical Center | Flint | Michigan | 48532 | — |
| Borgess Medical Center | Kalamazoo | Michigan | 49001 | — |
| CCOP - Kalamazoo | Kalamazoo | Michigan | 49001 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Seton Cancer Institute - Saginaw | Saginaw | Michigan | 48601 | — |
| St. John Macomb Hospital | Warren | Michigan | 48903 | — |
| Mayo Clinic Cancer Center | Rochester | Minnesota | 55905 | — |
| Cancer Institute of Cape Girardeau | Cape Girardeau | Missouri | 63703 | — |
| Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia | Missouri | 65203 | — |
| CCOP - Kansas City | Kansas City | Missouri | 64131 | — |
| CCOP - Cancer Research for the Ozarks | Springfield | Missouri | 65802 | — |
| St. John's Regional Health Center | Springfield | Missouri | 65804 | — |
| Hulston Cancer Center at Cox Medical Center South | Springfield | Missouri | 65807 | — |
| Saint Louis University Cancer Center | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center at Barnes-Jewish Hospital | St Louis | Missouri | 63110 | — |
| Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha | Omaha | Nebraska | 68114 | — |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | — |
| CCOP - Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | 89106 | — |
| Washoe Cancer Services at Washoe Medical Center - Reno | Reno | Nevada | 89502 | — |
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Cancer Institute of New Jersey at the Cooper University Hospital | Camden | New Jersey | 08103 | — |
| Monmouth Medical Center | Long Branch | New Jersey | 07740 | — |
| South Jersey Healthcare Regional Cancer Center | Millville | New Jersey | 08332 | — |
| Fox Chase Virtua Health Cancer Program - Marlton | Mount Holly | New Jersey | 08060 | — |
| Community Medical Center | Toms River | New Jersey | 08755 | — |
| New York Methodist Hospital | Brooklyn | New York | 11215 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| CCOP - North Shore University Hospital | Manhasset | New York | 11030 | — |
| Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center | Plattsburgh | New York | 12901 | — |
| SUNY Upstate Medical University Hospital | Syracuse | New York | 13210 | — |
| Randolph Hospital | Asheboro | North Carolina | 27203 | — |
| John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital | Eden | North Carolina | 27288 | — |
| Wayne Memorial Hospital, Incorporated | Goldsboro | North Carolina | 27534 | — |
| Wayne Radiation Oncology | Goldsboro | North Carolina | 27534 | — |
| Moses Cone Regional Cancer Center at Wesley Long Community Hospital | Greensboro | North Carolina | 27401 | — |
| Annie Penn Cancer Center | Reidsville | North Carolina | 27320 | — |
| Rutherford Hospital | Rutherfordton | North Carolina | 28139 | — |
| Wilson Medical Center | Wilson | North Carolina | 27893 | — |
| Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | 27157 | — |
| Trinity Cancer Care Center | Minot | North Dakota | 58701 | — |
| Akron City Hospital at Summa Health System | Akron | Ohio | 44304 | — |
| McDowell Cancer Center at Akron General Medical Center | Akron | Ohio | 44307 | — |
| Aultman Hospital Cancer Center at Aultman Health Foundation | Canton | Ohio | 44710-1799 | — |
| Grandview Hospital | Dayton | Ohio | 45405 | — |
| Good Samaritan Hospital | Dayton | Ohio | 45406 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Samaritan North Cancer Care Center | Dayton | Ohio | 45415 | — |
| Veterans Affairs Medical Center - Dayton | Dayton | Ohio | 45428 | — |
| CCOP - Dayton | Dayton | Ohio | 45429 | — |
| Charles F. Kettering Memorial Hospital | Kettering | Ohio | 45429 | — |
| St. Rita's Medical Center | Lima | Ohio | 45801 | — |
| Middletown Regional Hospital | Middletown | Ohio | 45044 | — |
| Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford | Salem | Ohio | 44460 | — |
| UVMC Cancer Care Center at Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| Cancer Treatment Center | Wooster | Ohio | 44691 | — |
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia | Ohio | 45385 | — |
| LaFortune Cancer Center at St. John Health System | Tulsa | Oklahoma | 74104 | — |
| Natalie Warren Bryant Cancer Center at St. Francis Hospital | Tulsa | Oklahoma | 74136 | — |
| Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | 19010 | — |
| Penn State Cancer Institute at Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Cancer Center at Paoli Memorial Hospital | Paoli | Pennsylvania | 19301 | — |
| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | 19107 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111-2497 | — |
| Albert Einstein Cancer Center | Philadelphia | Pennsylvania | 19141 | — |
| Mercy Hospital of Pittsburgh | Pittsburgh | Pennsylvania | 15219 | — |
| Mercy Hospital Cancer Center - Scranton | Scranton | Pennsylvania | 18501 | — |
| CCOP - MainLine Health | Wynnewood | Pennsylvania | 19096 | — |
| Lankenau Cancer Center at Lankenau Hospital | Wynnewood | Pennsylvania | 19096 | — |
| Rose Ramer Cancer Clinic at Anderson Area Medical Center | Anderson | South Carolina | 29621 | — |
| Bon Secours St. Francis Health System | Greenville | South Carolina | 29601 | — |
| Greenville Hospital System Cancer Center | Greenville | South Carolina | 29605 | — |
| CCOP - Greenville | Greenville | South Carolina | 29615 | — |
| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | Spartanburg | South Carolina | 29303 | — |
| CCOP - Upstate Carolina | Spartanburg | South Carolina | 29304 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center | Nashville | Tennessee | 37232 | — |
| Harrington Cancer Center | Amarillo | Texas | 79106 | — |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | — |
| M.D. Anderson Cancer Center at University of Texas | Houston | Texas | 77030 | — |
| Wilford Hall Medical Center | Lackland Air Force Base | Texas | 78236 | — |
| Cottonwood Hospital Medical Center | Murray | Utah | 84107 | — |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Utah Valley Regional Medical Center - Provo | Provo | Utah | 84603 | — |
| Utah Cancer Specialists at UCS Cancer Center | Salt Lake City | Utah | 84106 | — |
| Huntsman Cancer Institute at University of Utah | Salt Lake City | Utah | 84112 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Dixie Regional Medical Center | St. George | Utah | 84770 | — |
| Fletcher Allen Health Care - University Health Center Campus | Burlington | Vermont | 05401 | — |
| Danville Regional Medical Center | Danville | Virginia | 24541 | — |
| Rappahannock General Hospital | Kilmarnock | Virginia | 22482 | — |
| Naval Medical Center - Portsmouth | Portsmouth | Virginia | 23708-2197 | — |
| Veterans Affairs Medical Center - Richmond | Richmond | Virginia | 23249 | — |
| Massey Cancer Center at Virginia Commonwealth University | Richmond | Virginia | 23298-0037 | — |
| Community Memorial Health Center | South Hill | Virginia | 23970-0090 | — |
| North Star Lodge Cancer Center | Yakima | Washington | 98902 | — |
| Washington Hematology - Oncology Specialists | Yakima | Washington | 98902 | — |
| Schiffler Cancer Center at Wheeling Hospital | Wheeling | West Virginia | 26003 | — |
| Green Bay Oncology, Limited at St. Vincent Hospital | Green Bay | Wisconsin | 54301-3526 | — |
| St. Vincent Hospital | Green Bay | Wisconsin | 54301 | — |
| Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay | Wisconsin | 54303 | — |
| St. Mary's Hospital Medical Center | Green Bay | Wisconsin | 54303 | — |
| Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | 53792 | — |
| Holy Family Memorial Medical Center | Manitowoc | Wisconsin | 54221 | — |
| Bay Area Cancer Care Center at Bay Area Medical Center | Marinette | Wisconsin | 54143 | — |
| Community Memorial Hospital | Menomonee Falls | Wisconsin | 53051 | — |
| St. Mary's Cancer Center at Columbia St. Mary's Hospital - Milwaukee Campus | Milwaukee | Wisconsin | 53211 | — |
| Medical College of Wisconsin Cancer Center | Milwaukee | Wisconsin | 53226 | — |
| Veterans Affairs Medical Center - Milwaukee (Zablocki) | Milwaukee | Wisconsin | 53295 | — |
| Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | 53066-3896 | — |
| All Saints Cancer Center at All Saints Healthcare | Racine | Wisconsin | 53405 | — |
| Waukesha Memorial Hospital Regional Cancer Center | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00047008, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 7, 2023 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00047008 live on ClinicalTrials.gov.