S0427, Combination Chemotherapy & RT in Treating Patients With Stage III or Stage IV Cancer of the Oropharynx
Public ClinicalTrials.gov record NCT00268372. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Trial of Standard Fractionation Radiation and Concurrent Single Agent Cisplatin, With and Without Docetaxel, Cisplatin, and 5-Fluorouracil Induction Chemotherapy, in Patients With Advanced Oropharyngeal Squamous Cell Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy, such as docetaxel, cisplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy together with radiation therapy may kill more tumor cells. It is not yet known whether giving combination chemotherapy together with radiation therapy is more effective than giving cisplatin together with radiation therapy in treating cancer of the oropharynx. PURPOSE: This randomized phase III trial is studying combination chemotherapy and radiation therapy to see how well they work compared to cisplatin and radiation therapy in treating patients with stage III or stage IV cancer of the oropharynx.
Study identification
- NCT ID
- NCT00268372
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 6 participants
Conditions and interventions
Conditions
Interventions
- cisplatin Drug
- docetaxel Drug
- 5-fluorouracil Drug
- surgery Procedure
- radiation therapy Radiation
Drug · Procedure · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2005 (Type not available)
- Primary completion
- Dec 2007 (Actual)
- Completion
- Dec 2007 (Actual)
- Last update posted
- Oct 4, 2012
2005 – 2007
United States locations
- U.S. sites
- 74
- U.S. states
- 16
- U.S. cities
- 54
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | 06360 | — |
| Rush-Copley Cancer Care Center | Aurora | Illinois | 60507 | — |
| John H. Stroger, Jr. Hospital of Cook County | Chicago | Illinois | 60612-3785 | — |
| Decatur Memorial Hospital Cancer Care Institute | Decatur | Illinois | 62526 | — |
| Veterans Affairs Medical Center - Hines | Hines | Illinois | 60141 | — |
| Joliet Oncology-Hematology Associates, Limited - West | Joliet | Illinois | 60435 | — |
| Trinity Medical Center - East | Moline | Illinois | 61265 | — |
| Not listed | Moline | Illinois | 61265 | — |
| West Suburban Center for Cancer Care | River Forest | Illinois | 60305 | — |
| Regional Cancer Center at Memorial Medical Center | Springfield | Illinois | 62781-0001 | — |
| Carle Cancer Center at Carle Foundation Hospital | Urbana | Illinois | 61801 | — |
| CCOP - Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Saint Anthony Memorial Health Centers | Michigan City | Indiana | 46360 | — |
| Not listed | Bettendorf | Iowa | 52722 | — |
| Siouxland Hematology-Oncology Associates, LLP | Sioux City | Iowa | 51101 | — |
| Siouxland Regional Cancer Center | Sioux City | Iowa | 51101 | — |
| Mercy Medical Center - Sioux City | Sioux City | Iowa | 51104 | — |
| St. Luke's Regional Medical Center | Sioux City | Iowa | 51104 | — |
| Cancer Center of Kansas, PA - Chanute | Chanute | Kansas | 66720 | — |
| Cancer Center of Kansas, PA - Dodge City | Dodge City | Kansas | 67801 | — |
| Cancer Center of Kansas, PA - El Dorado | El Dorado | Kansas | 67042 | — |
| Cancer Center of Kansas, PA - Kingman | Kingman | Kansas | 67068 | — |
| Southwest Medical Center | Liberal | Kansas | 67901 | — |
| Cancer Center of Kansas, PA - Newton | Newton | Kansas | 67114 | — |
| Cancer Center of Kansas, PA - Parsons | Parsons | Kansas | 67357 | — |
| Cancer Center of Kansas, PA - Pratt | Pratt | Kansas | 67124 | — |
| Cancer Center of Kansas, PA - Salina | Salina | Kansas | 67042 | — |
| Tammy Walker Cancer Center at Salina Regional Health Center | Salina | Kansas | 67401 | — |
| Cancer Center of Kansas, PA - Wellington | Wellington | Kansas | 67152 | — |
| Associates in Womens Health, PA - North Review | Wichita | Kansas | 67203 | — |
| Cancer Center of Kansas, PA - Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas, PA - Wichita | Wichita | Kansas | 67214 | — |
| CCOP - Wichita | Wichita | Kansas | 67214 | — |
| Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita | Kansas | 67214 | — |
| Wesley Medical Center | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas, PA - Winfield | Winfield | Kansas | 67156 | — |
| Cancer Research Center at Boston Medical Center | Boston | Massachusetts | 02118 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109-0942 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007-3731 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| Borgess Medical Center | Kalamazooaa | Michigan | 49001 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| CCOP - Cancer Research for the Ozarks | Springfield | Missouri | 65802 | — |
| St. John's Regional Health Center | Springfield | Missouri | 65804 | — |
| Hulston Cancer Center at Cox Medical Center South | Springfield | Missouri | 65807 | — |
| Saint Louis University Cancer Center | St Louis | Missouri | 63110 | — |
| Capital Health System Regional Cancer Center | Trenton | New Jersey | 08618 | — |
| Wayne Memorial Hospital, Incorporated | Goldsboro | North Carolina | 27534 | — |
| Wayne Radiation Oncology | Goldsboro | North Carolina | 27534 | — |
| Lenoir Memorial Cancer Center | Kinston | North Carolina | 28501 | — |
| Rutherford Hospital | Rutherfordton | North Carolina | 28139 | — |
| Wilson Medical Center | Wilson | North Carolina | 27893-3428 | — |
| Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | 44195 | — |
| Community Oncology Group at Cleveland Clinic Cancer Center | Independence | Ohio | 44131 | — |
| St. Rita's Medical Center | Lima | Ohio | 45801 | — |
| Cleveland Clinic - Wooster | Wooster | Ohio | 44691 | — |
| Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest | Allentown | Pennsylvania | 18105 | — |
| AnMed Health Cancer Center | Anderson | South Carolina | 29621 | — |
| CCOP - Upstate Carolina | Spartanburg | South Carolina | 29303 | — |
| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | Spartanburg | South Carolina | 29303 | — |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | — |
| Wilford Hall Medical Center | Lackland Air Force Base | Texas | 78236 | — |
| Veterans Affairs Medical Center - San Antonio (Murphy) | San Antonio | Texas | 78209 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229-3900 | — |
| Cancer Therapy and Research Center | San Antonio | Texas | 78229 | — |
| University Hospital - San Antonio | San Antonio | Texas | 78229 | — |
| American Fork Hospital | American Fork | Utah | 84003 | — |
| Logan Regional Hospital | Logan | Utah | 84321 | — |
| Cottonwood Hospital Medical Center | Murray | Utah | 84107 | — |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Utah Valley Regional Medical Center - Provo | Provo | Utah | 84604 | — |
| Latter Day Saints Hospital | Salt Lake City | Utah | 84103 | — |
| Utah Cancer Specialists at UCS Cancer Center | Salt Lake City | Utah | 84106 | — |
| Dixie Regional Medical Center - East Campus | St. George | Utah | 84770 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00268372, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 4, 2012 · Synced Oct 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00268372 live on ClinicalTrials.gov.