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Completed Phase 4 Interventional Results available

Study Comparing Outcomes for Patients With Treatment Resistant Depression Who Receive VNS Therapy at Different Doses

ClinicalTrials.gov ID: NCT00305565

Public ClinicalTrials.gov record NCT00305565. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Sep 3, 2026, 7:11 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized Comparison of Outcomes in Patients With Treatment-Resistant Depression Who Receive VNS Therapy Administered at Different Amounts of Electrical Charge

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a postmarket medical device study. The objective of this study is to compare the safety and effectiveness of Vagus Nerve Stimulation (VNS) Therapy administered at different amounts of electrical charge for the treatment of patients with treatment-resistant depression (TRD).

Study identification

NCT ID
NCT00305565
Recruitment status
Completed
Study type
Interventional
Phase
Phase 4
Lead sponsor
Cyberonics, Inc.
Industry
Enrollment
331 participants

Conditions and interventions

Conditions

Interventions

Device

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 31, 2005
Primary completion
Jan 31, 2010
Completion
Jan 31, 2010
Last update posted
Jan 6, 2014

2006 – 2010

United States locations

U.S. sites
26
U.S. states
17
U.S. cities
24
Facility City State ZIP Site status
University of Arizona Tucson Arizona 85724
Sutter Institute for Medical Research Sacramento California 95816
Northwest Behavioral Research Center Marietta Georgia 30060
Evanston Northwestern Hospital Evanston Illinois 60201
Clinical Research Institute Wichita Kansas 67211
Brentwood Research Institute Shreveport Louisiana 71101
Sheppard Pratt Hospital Baltimore Maryland 21204
Pharmasite Research Inc. Baltimore Maryland 21208
Massachusetts General Hospital Charlestown Massachusetts 02129
Psychiatric Recovery Saint Paul Minnesota 55114
St. Louis University St Louis Missouri 63104
Dent Neurologic Institute Amherst New York 14226
Eastside Comprehensive Medical Center New York New York 10021
New York State Psychiatric Institute New York New York 10032
SUNY Upstate Medical University Syracuse New York 13210
Oregon Health & Science University Portland Oregon 97239
Penn State Milton S. Hershey Medical Center Hershey Pennsylvania 17033
University of Pennsylvania Philadelphia Pennsylvania 19104
University of Pittsburgh Pittsburgh Pennsylvania 15213
Butler Hospital Providence Rhode Island 02906
Community Clinical Research, Inc. Austin Texas 78756
UT Southwestern Medical Center Dallas Texas 75235-8898
Claghorn-Lesem Research Clinic, LTD Houston Texas 77401
University of Texas Health Science Center at San Antonio San Antonio Texas 78229
University of Utah Salt Lake City Utah 84132-2502
Center for Anxiety and Depression Mercer Island Washington 98040

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT00305565, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jan 6, 2014 · Synced Sep 3, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT00305565 live on ClinicalTrials.gov.

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