A Study of Mifepristone vs. Placebo in the Treatment of Patients With Major Depression With Psychotic Features
Public ClinicalTrials.gov record NCT00637494. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Mifepristone vs. Placebo in the Treatment of Psychotic Symptoms in Patients With Major Depressive Disorder With Psychotic Features
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Approximately 450 patients will be randomized to receive mifepristone or placebo for 7 days followed by antidepressant. The purpose is to compare the efficacy of mifepristone followed by antidepressant versus placebo followed by antidepressant in reducing psychotic symptoms in patients with a diagnosis of psychotic depression.
Study identification
- NCT ID
- NCT00637494
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 292 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 22 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2008 (Type not available)
- Primary completion
- Jun 2014 (Actual)
- Completion
- Jun 2014 (Actual)
- Last update posted
- Jun 5, 2017
2008 – 2014
United States locations
- U.S. sites
- 42
- U.S. states
- 16
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| K&S Professional Research Services, LLC | Little Rock | Arkansas | 72201 | — |
| Woodland International Research Group, Inc. | Little Rock | Arkansas | 72211 | — |
| South Coast Clinical Trials, Inc | Anaheim | California | 92804 | — |
| Diligent Clinical Trials | Downey | California | 90241 | — |
| Synergy Clinical Research Center | Escondido | California | 92025 | — |
| Collaborative Neuroscience Network, Inc. | Garden Grove | California | 92845 | — |
| Pacific Research Partners | Oakland | California | 94612 | — |
| North County Clinical Research | Oceanside | California | 92056 | — |
| Breakthrough Clinical Trials | San Bernardino | California | 92408 | — |
| Sharp Mesa Vista Hospital | San Diego | California | 92123 | — |
| Cnri, Llc | San Diego | California | 92126 | — |
| Professional Clinical Research, Inc. | Aventura | Florida | 33180 | — |
| University of Florida | Gainesville | Florida | 32606 | — |
| Segal Institute for Clinical Research | Hollywood | Florida | 33021 | — |
| Accurate Clinical Trials | Kissimmee | Florida | 34741 | — |
| AMB Research Center | Miami | Florida | 33144 | — |
| Lakeside Behavioral Health | Orlando | Florida | 32810 | — |
| University of South Florida Dept of Psychiatry and Neurosciences | Tampa | Florida | 33613 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30308 | — |
| Alexian Brothers Center for Psychiatric Research | Hoffman Estates | Illinois | 60169 | — |
| Precise Research Centers | Flowood | Mississippi | 39232 | — |
| Millennium Psychiatric Associate | Creve Coeur | Missouri | 63141 | — |
| PsychCare Consultants Research | St Louis | Missouri | 63128 | — |
| CRI Lifetree | Marlton | New Jersey | 08053 | — |
| Neurobehavioral Research, Inc. | Cedarhurst | New York | 11516 | — |
| The Zucker Hillside Hospital | Glen Oaks | New York | 11004 | — |
| Inquest Clinical Group/ Global Research Associates | Hope Mills | North Carolina | 28348 | — |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| Midwest Clinical Research Center | Dayton | Ohio | 45417 | — |
| Oklahoma Clinical Research Center | Oklahoma City | Oklahoma | 73112 | — |
| Lehigh Center for Clinical Research | Allentown | Pennsylvania | 18104 | — |
| Belmont Center for Comprehensive Treatment | Philadelphia | Pennsylvania | 19131 | — |
| University of Pittsburgh Medical Center (UPMC) | Pittsburgh | Pennsylvania | 15213 | — |
| Carolina Clinical Trials, Inc. | Charleston | South Carolina | 29405 | — |
| FutureSearch Clinical Trials, L.P. | Austin | Texas | 78731 | — |
| Pillar Clinical Research, LLC | Dallas | Texas | 75243 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| InSite Clinical Research, LLC | DeSoto | Texas | 75115 | — |
| Claghorn-Lesem Research Clinic | Houston | Texas | 77008 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| Fein-Jennings Clinic, Inc. | Houston | Texas | 77074 | — |
| Lifetree Clinical Research | Salt Lake City | Utah | 84106 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00637494, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 5, 2017 · Synced Oct 27, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00637494 live on ClinicalTrials.gov.