ClinicalTrials.gov record
RT With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer
ClinicalTrials.gov ID: NCT00956007
Public ClinicalTrials.gov record NCT00956007. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Giving radiation therapy that uses a 3-dimensional (3-D) image of the tumor to help focus thin beams of radiation directly on the tumor, and giving radiation therapy in higher doses over a shorter period of time, may kill more tumor cells and have fewer side effects. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether radiation therapy is more effective when given alone or together with cetuximab in treating patients with head and neck cancer that has been removed by surgery. PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with cetuximab in treating patients who have undergone surgery for locally advanced head and neck cancer.
Study identification
- NCT ID
- NCT00956007
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 702 participants
Conditions and interventions
Conditions
Interventions
- cetuximab Biological
- intensity-modulated radiation therapy Radiation
Biological · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 31, 2010 (Actual)
- Primary completion
- Sep 5, 2023 (Actual)
- Completion
- Aug 2029 (Estimated)
- Last update posted
- Jan 6, 2026
2010 – 2029
United States locations
- U.S. sites
- 250
- U.S. states
- 44
- U.S. cities
- 194
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Arizona Oncology Associates-West Orange Grove | Tucson | Arizona | 85704 | — |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California | 95603 | — |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California | 95682 | — |
| Mercy San Juan Medical Center | Carmichael | California | 95608 | — |
| City of Hope | Duarte | California | 91010 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Los Angeles County-USC Medical Center | Los Angeles | California | 90033 | — |
| University of Southern California/Norris Cancer Center | Los Angeles | California | 90033 | — |
| Memorial Medical Center | Modesto | California | 95355 | — |
| Bay Area Tumor Institute CCOP | Oakland | California | 94609 | — |
| Pomona Valley Hospital Medical Center | Pomona | California | 91767 | — |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | 95661 | — |
| The Permanente Medical Group-Roseville Radiation Oncology | Roseville | California | 95678 | — |
| Sutter General Hospital | Sacramento | California | 95816 | — |
| University of California at Davis Cancer Center | Sacramento | California | 95817 | — |
| Mercy General Hospital Radiation Oncology Center | Sacramento | California | 95819 | — |
| UCSF-Mount Zion | San Francisco | California | 94115 | — |
| Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | 95051 | — |
| Saint Helena Hospital | St. Helena | California | 94574 | — |
| Stanford University Hospitals and Clinics | Stanford | California | 94305 | — |
| Sutter Cancer Centers Radiation Oncology Services-Vacaville | Vacaville | California | 95687 | — |
| Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | 80012 | — |
| University of Colorado Cancer Center - Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | — |
| Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | 80907 | — |
| Porter Adventist Hospital | Denver | Colorado | 80210 | — |
| Swedish Medical Center | Englewood | Colorado | 80113 | — |
| Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | 80120 | — |
| Saint Vincent's Medical Center | Bridgeport | Connecticut | 06606 | — |
| Yale University | New Haven | Connecticut | 06520 | — |
| William Backus Hospital | Norwich | Connecticut | 06360 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224-9980 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Baptist Hospital of Miami | Miami | Florida | 33176 | — |
| Florida Hospital | Orlando | Florida | 32803 | — |
| UF Cancer Center at Orlando Health | Orlando | Florida | 32806 | — |
| Emory University/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Atlanta VA Medical Center | Decatur | Georgia | 30033 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31403 | — |
| Saint Joseph's-Candler Health System | Savannah | Georgia | 31405 | — |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| University of Hawaii | Honolulu | Hawaii | 96813 | — |
| The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | 96817 | — |
| Saint Alphonsus Regional Medical Center | Boise | Idaho | 83706 | — |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612-3785 | — |
| University of Illinois | Chicago | Illinois | 60612 | — |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | 60201 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Hines Veterans Administration Hospital | Hines | Illinois | 60141 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Saint John's Hospital | Springfield | Illinois | 62702 | — |
| Memorial Medical Center | Springfield | Illinois | 62781-0001 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Radiation Oncology Associates PC | Fort Wayne | Indiana | 46804 | — |
| Parkview Hospital Randallia | Fort Wayne | Indiana | 46805 | — |
| IU Health Methodist Hospital | Indianapolis | Indiana | 46202 | — |
| Community Regional Cancer Care-East Radiation Oncology | Indianapolis | Indiana | 46219 | — |
| Community Regional Cancer Care-North | Indianapolis | Indiana | 46256 | — |
| IU Health Ball Memorial Hospital | Muncie | Indiana | 47303 | — |
| McFarland Clinic PC-William R Bliss Cancer Center | Ames | Iowa | 50010 | — |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Siouxland Hematology Oncology Associates | Sioux City | Iowa | 51101 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | 40202 | — |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | — |
| Tulane University Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Touro Infirmary | New Orleans | Louisiana | 70115 | — |
| Central Maine Medical Center | Lewiston | Maine | 04240 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Peninsula Regional Medical Center | Salisbury | Maryland | 21801 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Lahey Hospital and Medical Center | Burlington | Massachusetts | 01805 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106-0995 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Oakwood Hospital | Dearborn | Michigan | 48124 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Saint John Hospital and Medical Center | Detroit | Michigan | 48236 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Saint Mary's of Michigan | Saginaw | Michigan | 48601 | — |
| Saint John Macomb-Oakland Hospital | Warren | Michigan | 48093 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Saint Luke's Hospital of Duluth | Duluth | Minnesota | 55805 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Singing River Hospital | Pascagoula | Mississippi | 39581 | — |
| Cape Radiation Oncology | Cape Girardeau | Missouri | 63703 | — |
| Siteman Cancer Center - Saint Peters | City of Saint Peters | Missouri | 63376 | — |
| University of Missouri - Ellis Fischel | Columbia | Missouri | 65212 | — |
| Kansas City Cancer Centers - North | Kansas City | Missouri | 64154 | — |
| Kansas City Cancer Center-Lee's Summit | Lee's Summit | Missouri | 64064 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Saint Louis University Hospital | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Barnes-Jewish West County Hospital | St Louis | Missouri | 63141 | — |
| Saint John's Mercy Medical Center | St Louis | Missouri | 63141 | — |
| Saint Elizabeth Regional Medical Center | Lincoln | Nebraska | 68510 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| The Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Exeter Hospital | Exeter | New Hampshire | 03833 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Memorial Sloan Kettering Cancer Center at Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| Cooper Hospital University Medical Center | Camden | New Jersey | 08103 | — |
| Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County | Mount Holly | New Jersey | 08060 | — |
| Saint Peter's University Hospital | New Brunswick | New Jersey | 08901 | — |
| UMDNJ - New Jersey Medical School | Newark | New Jersey | 07103 | — |
| Sparta Cancer Treatment Center | Sparta | New Jersey | 07871 | — |
| MD Anderson Cancer Center at Cooper-Voorhees | Voorhees Township | New Jersey | 08043 | — |
| University of New Mexico | Albuquerque | New Mexico | 87106 | — |
| New York Oncology Hematology PC - Albany | Albany | New York | 12206 | — |
| Maimonides Medical Center | Brooklyn | New York | 11219 | — |
| Sands Cancer Center | Canandaigua | New York | 14424 | — |
| Memorial Sloan Kettering Cancer Center Commack | Commack | New York | 11725 | — |
| Beth Israel Medical Center | New York | New York | 10003 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10065 | — |
| Highland Hospital | Rochester | New York | 14620 | — |
| University Radiation Oncology | Rochester | New York | 14626 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Memorial Sloan-Kettering Cancer Center Rockville Centre | Rockville Centre | New York | 11570 | — |
| Memorial Sloan-Kettering Cancer Center at Sleepy Hallow | Sleepy Hollow | New York | 10591 | — |
| Mission Hospital-Memorial Campus | Asheville | North Carolina | 28801 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | — |
| Wayne Radiation Oncology | Goldsboro | North Carolina | 27534 | — |
| Kinston Medical Specialists PA | Kinston | North Carolina | 28501 | — |
| Cancer Centers of North Carolina | Raleigh | North Carolina | 27607 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| Summa Akron City Hospital/Cooper Cancer Center | Akron | Ohio | 44304 | — |
| Akron General Medical Center | Akron | Ohio | 44307 | — |
| Summa Barberton Hospital | Barberton | Ohio | 44203 | — |
| Mercy Medical Center | Canton | Ohio | 44708 | — |
| Geaugra Hospital | Chardon | Ohio | 44024 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | 44111 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| Mercy Cancer Center-Elyria | Elyria | Ohio | 44035 | — |
| Cleveland Clinic Cancer Center Independence | Independence | Ohio | 44131 | — |
| Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | 44124 | — |
| Summa Health Center at Lake Medina | Medina | Ohio | 44256 | — |
| Lake University Ireland Cancer Center | Mentor | Ohio | 44060 | — |
| Southwest General Health Center Ireland Cancer Center | Middleburg Heights | Ohio | 44130 | — |
| UHHS-Chagrin Highlands Medical Center | Orange | Ohio | 44122 | — |
| Saint Charles Hospital | Oregon | Ohio | 43616 | — |
| Robinson Radiation Oncology | Ravenna | Ohio | 44266 | — |
| North Coast Cancer Care | Sandusky | Ohio | 44870 | — |
| Cleveland Clinic Cancer Center-Strongsville | Strongsville | Ohio | 44136 | — |
| Flower Hospital | Sylvania | Ohio | 43560 | — |
| University Pointe | West Chester | Ohio | 45069 | — |
| UHHS-Westlake Medical Center | Westlake | Ohio | 44145 | — |
| Cleveland Clinic Wooster Specialty Center | Wooster | Ohio | 44691 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Clackamas Radiation Oncology Center | Clackamas | Oregon | 97015 | — |
| Willamette Valley Cancer Center | Eugene | Oregon | 97401 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Western Oncology Research Consortium | Portland | Oregon | 97213 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Portland Veterans Administration Medical Center | Portland | Oregon | 97239 | — |
| Salem Hospital | Salem | Oregon | 97301 | — |
| Lehigh Valley Hospital | Allentown | Pennsylvania | 18105 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822-2001 | — |
| Northeast Radiation Oncology Center | Dunmore | Pennsylvania | 18512 | — |
| Pocono Medical Center | East Stroudsburg | Pennsylvania | 18301 | — |
| Adams Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| Cherry Tree Cancer Center | Hanover | Pennsylvania | 17331 | — |
| Saint Mary Medical and Regional Cancer Center | Langhorne | Pennsylvania | 19047 | — |
| University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Albert Einstein Medical Center | Philadelphia | Pennsylvania | 19141 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| WellSpan Health-York Hospital | York | Pennsylvania | 17405 | — |
| AnMed Health Cancer Center | Anderson | South Carolina | 29621 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Greenville Health System Cancer Institute-Faris | Greenville | South Carolina | 29605 | — |
| Greenville Health System Cancer Institute/Greenville CCOP | Greenville | South Carolina | 29615 | — |
| Gibbs Cancer Center-Pelham | Greer | South Carolina | 29651 | — |
| Spartanburg Regional Medical Center | Spartanburg | South Carolina | 29303 | — |
| Greenville Health System Cancer Institute-Spartanburg | Spartanburg | South Carolina | 29307 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Sanford Cancer Center-Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee | 37660 | — |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Texas Oncology-Austin Midtown | Austin | Texas | 78705 | — |
| Texas Oncology - Central Austin Cancer Center | Austin | Texas | 78731 | — |
| Texas Oncology - South Austin Cancer Center | Austin | Texas | 78745 | — |
| Texas Oncology PA - Bedford | Bedford | Texas | 76022 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Texas Oncology-Denton South | Denton | Texas | 76210 | — |
| The Klabzuba Cancer Center | Fort Worth | Texas | 76104 | — |
| Memorial Hermann Memorial City Medical Center | Houston | Texas | 77024 | — |
| Ben Taub General Hospital | Houston | Texas | 77030 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| Texas Oncology-Seton Williamson | Round Rock | Texas | 78665 | — |
| Texas Oncology - Round Rock Cancer Center | Round Rock | Texas | 78681 | — |
| Cancer Care Centers of South Texas- Northeast | San Antonio | Texas | 78217 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| Texas Cancer Center-Sherman | Sherman | Texas | 75090 | — |
| Texas Oncology Cancer Center Sugar Land | Sugar Land | Texas | 77479 | — |
| Texas Oncology-Wichita Falls Texoma Cancer Center | Wichita Falls | Texas | 76310 | — |
| Intermountain Medical Center | Murray | Utah | 84157 | — |
| Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | 84106 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Dixie Medical Center Regional Cancer Center | St. George | Utah | 84770 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Sentara Cancer Institute at Sentara CarePlex Hospital | Hampton | Virginia | 23666 | — |
| Sentara Hospitals | Norfolk | Virginia | 23507 | — |
| Hunter Holmes McGuire Veterans Administration Medical Center | Richmond | Virginia | 23249 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Sentara Virginia Beach General Hospital | Virginia Beach | Virginia | 23454 | — |
| Harrison Medical Center | Bremerton | Washington | 98310 | — |
| Tri-Cities Cancer Center | Kennewick | Washington | 99336 | — |
| Skagit Valley Hospital | Mount Vernon | Washington | 98274 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Cancer Care Northwest - Spokane South | Spokane | Washington | 99202 | — |
| Cancer Care Northwest-North Spokane | Spokane | Washington | 99218 | — |
| Northwest CCOP | Tacoma | Washington | 98405 | — |
| PeaceHealth Southwest Medical Center | Vancouver | Washington | 98664 | — |
| Compass Oncology Vancouver | Vancouver | Washington | 98684 | — |
| Wenatchee Valley Medical Center | Wenatchee | Washington | 98801 | — |
| West Virginia University Healthcare | Morgantown | West Virginia | 26506 | — |
| Wheeling Hospital | Wheeling | West Virginia | 26003 | — |
| Langlade Hospital and Cancer Center | Antigo | Wisconsin | 54409 | — |
| Fox Valley Hematology and Oncology | Appleton | Wisconsin | 54911-3496 | — |
| Saint Vincent Hospital | Green Bay | Wisconsin | 54301 | — |
| Gundersen Lutheran | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
| Bay Area Medical Center | Marinette | Wisconsin | 54143 | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Clement J. Zablocki VA Medical Center | Milwaukee | Wisconsin | 53295 | — |
| Door County Cancer Center | Sturgeon Bay | Wisconsin | 54235-1495 | — |
| Aspirus Regional Cancer Center | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00956007, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 6, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00956007 live on ClinicalTrials.gov.