A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder (MDD)
Public ClinicalTrials.gov record NCT01157078. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Parallel Group, Placebo-Controlled, Phase III Efficacy and Safety Study of TC-5214 (S-mecamylamine) in Flexible Doses as an Adjunct to an Antidepressant in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine if TC-5214 or placebo (a tablet that looks like medicine tablet or capsule, but contains no active medicine) is safe and effective when taken together with another antidepressant.
Study identification
- NCT ID
- NCT01157078
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 319 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2010 (Type not available)
- Primary completion
- Nov 2011 (Actual)
- Completion
- Nov 2011 (Actual)
- Last update posted
- Apr 11, 2014
2010 – 2011
United States locations
- U.S. sites
- 37
- U.S. states
- 19
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Tuscaloosa | Alabama | — | — |
| Research Site | Tucson | Arizona | — | — |
| Research Site | Little Rock | Arkansas | — | — |
| Research Site | Chino | California | — | — |
| Research Site | Costa Mesa | California | — | — |
| Research Site | Encino | California | — | — |
| Research Site | Escondido | California | — | — |
| Research Site | Los Alamitos | California | — | — |
| Research Site | Oceanside | California | — | — |
| Research Site | Pico Rivera | California | — | — |
| Research Site | San Diego | California | — | — |
| Research Site | Torrance | California | — | — |
| Research Site | Hamden | Connecticut | — | — |
| Research Site | Coral Springs | Florida | — | — |
| Research Site | Jacksonville | Florida | — | — |
| Research Site | Orange City | Florida | — | — |
| Research Site | Orlando | Florida | — | — |
| Research Site | Tampa | Florida | — | — |
| Research Site | Chicago | Illinois | — | — |
| Research Site | Prairie Village | Kansas | — | — |
| Research Site | Florence | Kentucky | — | — |
| Research Site | Shreveport | Louisiana | — | — |
| Research Site | St Louis | Missouri | — | — |
| Research Site | New York | New York | — | — |
| Research Site | Rochester | New York | — | — |
| Research Site | Staten Island | New York | — | — |
| Research Site | Cincinnati | Ohio | — | — |
| Research Site | Dayton | Ohio | — | — |
| Research Site | Middleburg Heights | Ohio | — | — |
| Research Site | Portland | Oregon | — | — |
| Research Site | Salem | Oregon | — | — |
| Research Site | Norristown | Pennsylvania | — | — |
| Research Site | Charleston | South Carolina | — | — |
| Research Site | Dallas | Texas | — | — |
| Research Site | Houston | Texas | — | — |
| Research Site | Woodstock | Vermont | — | — |
| Research Site | Seattle | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01157078, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 11, 2014 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01157078 live on ClinicalTrials.gov.