Examining the Impact of Sirolimus on Ketamine's Antidepressant Effects

ClinicalTrials.gov ID: NCT02487485

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The aim of the study is to provide insight into the impact of the immunosuppressant drug sirolimus, on the antidepressant effects of the prototypal rapid-acting antidepressant medication, ketamine.

Study identification

NCT ID: NCT02487485
Recruitment status: Completed
Study type: Interventional
Phase: Phase 2
Lead sponsor: Yale University; Other
Enrollment: 23 participants

Conditions and interventions

Conditions

Depression

Interventions

Ketamine Drug
sirolimus Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 21 Years to 65 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 2016 (Type not available)
Primary completion: Jan 2020 (Actual)
Completion: Jan 2020 (Actual)
Last update posted: Jul 16, 2020

2016 – 2020

United States locations

U.S. sites: 2
U.S. states: 1
U.S. cities: 2

Facility	City	State	ZIP	Site status
Yale New Haven Hospital	New Haven	Connecticut	06511	—
West Haven Veterans Affairs	West Haven	Connecticut	06516	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT02487485, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jul 16, 2020 · Synced Nov 15, 2026