A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes
Public ClinicalTrials.gov record NCT03987919. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-Label Trial Comparing Efficacy and Safety of Tirzepatide Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Patients With Type 2 Diabetes
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The reason for this study is to compare the effect of the study drug tirzepatide to semaglutide on blood sugar levels in participants with type 2 diabetes. The study will last approximately 47 weeks and may include about 12 visits.
Study identification
- NCT ID
- NCT03987919
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,879 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 30, 2019 (Actual)
- Primary completion
- Jan 28, 2021 (Actual)
- Completion
- Feb 15, 2021 (Actual)
- Last update posted
- Feb 14, 2022
2019 – 2021
United States locations
- U.S. sites
- 51
- U.S. states
- 22
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cahaba Research | Birmingham | Alabama | 35242 | — |
| Syed Research Consultants Llc | Sheffield | Alabama | 35660 | — |
| National Research Institute - Huntington Park | Huntington Park | California | 90255 | — |
| Catalina Research Institute, LLC | Montclair | California | 91763 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| National Research Institute - Huntington Park | Panorama City | California | 91402 | — |
| Artemis Institute for Clinical Research | Riverside | California | 92503 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92103 | — |
| Artemis Institute for Clinical Research | San Marcos | California | 92078 | — |
| University Clinical Investigators, Inc. | Tustin | California | 92780 | — |
| CMR of Greater New Haven | Hamden | Connecticut | 06517 | — |
| Clinical Research of South Florida | Coral Gables | Florida | 33134 | — |
| East Coast Institute for Research at The Jones Center | Lake City | Florida | 32055 | — |
| South Florida Clinical Research Institute | Margate | Florida | 33063 | — |
| Suncoast Research Group | Miami | Florida | 33135 | — |
| New Horizon Research Center | Miami | Florida | 33165 3338 | — |
| Oviedo Medical Research | Oviedo | Florida | 32765 | — |
| South Broward Research | Pembroke Pines | Florida | 33027 | — |
| United Osteoporosis Center | Gainesville | Georgia | 30501 | — |
| Sky Clinical Research Network | Union City | Georgia | 30291 | — |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | — |
| University of Iowa Hospital & Clinic | Iowa City | Iowa | 52242 | — |
| Cotton O'Neil Clinic | Topeka | Kansas | 66606 | — |
| Cotton O'Neil Diabetes and Endocrinology Center | Topeka | Kansas | 66606 | — |
| NECCR PrimaCare Research | Fall River | Massachusetts | 02721 | — |
| ActivMed Practices and Research | Methuen | Massachusetts | 01844 | — |
| Olive Branch Family Medical Center | Olive Branch | Mississippi | 38654 | — |
| Clinvest Research LLC | Springfield | Missouri | 65810 | — |
| Premier Research | Trenton | New Jersey | 08611 | — |
| Albany Medical College, Division of Community Endocrinology | Albany | New York | 12206 | — |
| PharmQuest | Greensboro | North Carolina | 27408 | — |
| Diabetes & Endocrinology Consultants, PC | Morehead City | North Carolina | 28557 | — |
| PMG Research of Wilmington | Wilmington | North Carolina | 28401 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Aventiv Research Inc | Columbus | Ohio | 43213 | — |
| Intend Research, LLC | Norman | Oklahoma | 73069 | — |
| Heritage Valley Medical Group, Inc. | Beaver | Pennsylvania | 15009 | — |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | — |
| Detweiler Family Medicine & Associates | Lansdale | Pennsylvania | 19446 | — |
| Green & Seidner Family Practice Associates | Lansdale | Pennsylvania | 19446 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair | Pittsburgh | Pennsylvania | 15243 | — |
| Holston Medical Group | Bristol | Tennessee | 37620 | — |
| Dallas Diabetes Research Center | Dallas | Texas | 75230 | — |
| Biopharma Informatic, Inc. | Houston | Texas | 77043 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Carl R. Meisner Medical Clinic, PLLC | Sugar Land | Texas | 77478 | — |
| Martin Diagnostic Clinic | Tomball | Texas | 77375 | — |
| Burke Internal Medicine and Research | Burke | Virginia | 22015 | — |
| Capital Clinical Research Center | Olympia | Washington | 98502 | — |
| The Vancouver Clinic | Vancouver | Washington | 98664 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 76 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03987919, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 14, 2022 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03987919 live on ClinicalTrials.gov.