A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

ClinicalTrials.gov ID: NCT04378790

Public ClinicalTrials.gov record NCT04378790. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 22, 2026, 11:57 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Trial to Evaluate Sequential vs Simultaneous Spectacles Plus Patching for Amblyopia in Children 3 to <13 Years Old

Study identification

NCT ID: NCT04378790
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Jaeb Center for Health Research; Other
Enrollment: 544 participants

Conditions and interventions

Conditions

Amblyopia

Interventions

Patching Other
Glasses Other

Other

Eligibility (public fields only)

Age range: 3 Years to 13 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 7, 2020
Primary completion: Apr 30, 2028
Completion: Apr 30, 2028
Last update posted: Feb 10, 2026

2020 – 2028

United States locations

U.S. sites: 68
U.S. states: 28
U.S. cities: 60

Facility	City	State	ZIP	Site status
UAB Pediatric Eye Care; Birmingham Health Care	Birmingham	Alabama	35294	Recruiting
University of Alabama at Birmingham	Birmingham	Alabama	35294	Recruiting
Midwestern University Eye Institute	Glendale	Arizona	85308	Recruiting
Arizonia Pediatric Eye Specialists	Phoenix	Arizona	85006	Recruiting
University of Arizona	Tucson	Arizona	85711	Recruiting
Univ. of California- Berkeley	Berkeley	California	94720	Recruiting
Marshall B. Ketchum University	Fullerton	California	92831	Recruiting
Univ of California, Irvine- Gavin Herbert Eye Institute	Irvine	California	92697	Recruiting
Loma Linda University Health Care, Dept. of Ophthalmology	Loma Linda	California	92354	Recruiting
Children's Hospital of Los Angeles (CHLA)	Los Angeles	California	90027	Recruiting
Stanford University	Palo Alto	California	94303	Recruiting
Western University College of Optometry	Pomona	California	91766	Recruiting
University of California, Davis	Sacramento	California	95817	Recruiting
University of California San Francisco Department of Ophthalmology	San Francisco	California	94143	Recruiting
Eye Physicians & Surgeons, PC	Milford	Connecticut	06460	Recruiting
Nova Southeastern University College of Optometry, The Eye Institute	Fort Lauderdale	Florida	33382	Recruiting
Nemours Children's Clinic	Jacksonville	Florida	32207	Recruiting
University of South Florida (USF) Eye	Tampa	Florida	33620	Recruiting
St Luke's Hospital	Boise	Idaho	83702	Recruiting
Ann & Robert H. Lurie Children's Hospital of Chicago	Chicago	Illinois	60611	Recruiting
Ticho Eye Associates	Chicago Ridge	Illinois	60415	Recruiting
Midwestern U Chicago College of Optometry	Downers Grove	Illinois	60515	Recruiting
Progressive Eye Care	Lisle	Illinois	60532	Recruiting
Indiana School of Optometry	Bloomington	Indiana	47405	Recruiting
Indiana University School of Optometry	Indianapolis	Indiana	47405	Recruiting
Wolfe Eye Clinic	West Des Moines	Iowa	50266	Recruiting
Wilmer Eye Institute	Baltimore	Maryland	21287-9028	Recruiting
Boston Medical Center	Boston	Massachusetts	02118	Recruiting
Boston Children's Hospital Waltham	Boston	Massachusetts	02453	Recruiting
Corewell Health	Grand Rapids	Michigan	49503	Recruiting
Pediatric Ophthalmology, P.C.	Grand Rapids	Michigan	49546	Recruiting
Zenith Vision Development Center	Duluth	Minnesota	55811	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
PineCone Vision Center	Sartell	Minnesota	56377	Recruiting
Children's Mercy Hospitals and Clinics	Kansas City	Missouri	64108	Recruiting
St. Louis Children's Hospital Eye Center	St Louis	Missouri	63110	Recruiting
U of MO St. Louis College of Optometry	St Louis	Missouri	63121	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68114	Recruiting
Ross Eye Institute, University of Buffalo, Med School Dept Ophthalmology	Buffalo	New York	14209	Recruiting
NYU Langone Health	New York	New York	10017	Recruiting
State University of New York, College of Optometry	New York	New York	10036	Recruiting
University of North Carolina	Chapel Hill	North Carolina	27599	Recruiting
Duke University Eye Center	Durham	North Carolina	27710	Recruiting
Akron Children's Hospital	Akron	Ohio	44308	Recruiting
Cincinnati Children's Hospital	Cincinnati	Ohio	45229	Recruiting
Ohio State University College of Optometry	Columbus	Ohio	43210-1280	Recruiting
Dean A. McGee Eye Institute	Oklahoma City	Oklahoma	73104	Recruiting
River View Family Eyecare	Albany	Oregon	97321	Recruiting
Casey Eye Institute	Portland	Oregon	97239	Recruiting
Pediatric Ophthalmology of Erie	Erie	Pennsylvania	16501	Recruiting
Conestoga Eye	Lancaster	Pennsylvania	17601	Recruiting
Wills Eye Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Salus University/Pennsylvania College of Optometry	Philadelphia	Pennsylvania	19141	Recruiting
UPMC Children's Eye Center of Children's Hospital of Pittsburgh	Pittsburgh	Pennsylvania	15224	Recruiting
Prisma Health	Columbia	South Carolina	29203	Recruiting
Southern College of Optometry	Memphis	Tennessee	38104	Recruiting
Vanderbilt University Medical Center - Vanderbilt Eye Institute	Nashville	Tennessee	37232	Recruiting
Pediatric Eye Specialists, LLP	Fort Worth	Texas	76014	Recruiting
Baylor College of Medicine	Houston	Texas	77030	Recruiting
Texas Tech University Health Science Center	Lubbock	Texas	79430	Recruiting
University of the Incarnate Word	San Antonio	Texas	78209	Recruiting
San Antonio Eye Center	San Antonio	Texas	78215	Recruiting
University of Incarnate Word Rosenberg School of Optometry	San Antonio	Texas	78229	Recruiting
Rocky Mountain Eye Care Associates	Salt Lake City	Utah	84107	Recruiting
Virginia Pediatric Eye Center	Norfolk	Virginia	23502	Recruiting
Seattle Children's Hospital, University of Washington	Seattle	Washington	98105	Recruiting
Spokane Eye Clinical Research	Spokane	Washington	99204	Recruiting
Snowy Range Vision Center	Laramie	Wyoming	82070	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04378790, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 10, 2026 · Synced Jul 22, 2026

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The complete protocol, eligibility criteria, and contact information for NCT04378790 live on ClinicalTrials.gov.

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