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Completed Phase 1Phase 2 Interventional

A Study to Evaluate NT219 Alone and in Combination with ERBITUX® (Cetuximab) in Adults with Advanced Solid Tumors and Head and Neck Cancer

ClinicalTrials.gov ID: NCT04474470

Public ClinicalTrials.gov record NCT04474470. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 5, 2026, 6:21 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2 Study with Open-Label, Dose Escalation Phase Followed by Single-Arm Expansion At the Maximum Tolerated Dose to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of NT219 Injection Alone and in Combination with ERBITUX® (Cetuximab) in Adults with Advanced Solid Tumors and Head and Neck Cancer

Study identification

NCT ID
NCT04474470
Recruitment status
Completed
Study type
Interventional
Phase
Phase 1, Phase 2
Lead sponsor
TyrNovo Ltd.
Industry
Enrollment
52 participants

Conditions and interventions

Interventions

  • NT219 Drug
  • NT219 and ERBITUX® - Dose Escalation Drug
  • NT219 and ERBITUX® - Expansion Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Sep 2, 2020
Primary completion
May 7, 2024
Completion
May 7, 2024
Last update posted
Sep 18, 2024

2020 – 2024

United States locations

U.S. sites
7
U.S. states
5
U.S. cities
7
Facility City State ZIP Site status
California Cancer Associates for Research and Excellence Encinitas California 92024
The Angeles Clinic and Research Institute Los Angeles California 90025
UCSD Moores Cancer Center San Diego California 92037
MedStar Georgetown University Hospital Washington D.C. District of Columbia 20007
The University of Chicago and Biological Sciences Chicago Illinois 60637
Ochsner Clinic Foundation New Orleans Louisiana 70121
Stephenson Cancer Center Oklahoma City Oklahoma 73117

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT04474470, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 18, 2024 · Synced May 5, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04474470 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →