A Study of Tirzepatide (LY3298176) Versus Insulin Lispro (U100) in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin
Public ClinicalTrials.gov record NCT04537923. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Phase 3, Open-label Trial Comparing the Effect of the Addition of Tirzepatide Once Weekly Versus Insulin Lispro (U100) Three Times Daily in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin (SURPASS-6)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare the safety and efficacy of the study drug tirzepatide to insulin lispro (U100) three times a day in participants with type 2 diabetes that are already on insulin glargine (U100), with or without metformin.
Study identification
- NCT ID
- NCT04537923
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,428 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 19, 2020 (Actual)
- Primary completion
- Oct 11, 2022 (Actual)
- Completion
- Nov 1, 2022 (Actual)
- Last update posted
- Nov 2, 2023
2020 – 2022
United States locations
- U.S. sites
- 40
- U.S. states
- 17
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Syed Research Consultants Llc | Sheffield | Alabama | 35660 | — |
| Valley Research | Fresno | California | 93720 | — |
| National Research Institute - Huntington Park | Huntington Park | California | 90255 | — |
| National Research Institute - Huntington Park | Los Angeles | California | 90057 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| National Research Institute - Huntington Park | Panorama City | California | 91402 | — |
| National Research Institute (NRI) - Santa Ana | Santa Ana | California | 92704 | — |
| Encompass Clinical Research | Spring Valley | California | 91978 | — |
| University Clinical Investigators, Inc. | Tustin | California | 92780 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| I R & Health Center, Inc. | Hialeah | Florida | 33012 | — |
| Sun Coast Clinical Research, Inc | New Port Richey | Florida | 34652 | — |
| South Broward Research | Pembroke Pines | Florida | 33027 | — |
| Metabolic Research Institute, Inc. | West Palm Beach | Florida | 33401 | — |
| Rocky Mountain Clinical Research | Idaho Falls | Idaho | 83404 | — |
| J H. Stroger Hosp of Cook Co | Chicago | Illinois | 60612 | — |
| Prairie Education and Research Cooperative | Springfield | Illinois | 62711 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50265 | — |
| Capital Diabetes and Endocrine Associates | Camp Springs | Maryland | 20746 | — |
| MedStar Health Research Institute | Hyattsville | Maryland | 20782 | — |
| Endocrine and Metabolic Consultants | Rockville | Maryland | 20852 | — |
| Glacier View Research Institute - Endocrinology | Kalispell | Montana | 59901 | — |
| Southern Nh Diabetes and Endocrinology | Nashua | New Hampshire | 03060 | — |
| Albany Medical College | Albany | New York | 12203 | — |
| PMG Research of Wilmington | Wilmington | North Carolina | 28401 | — |
| Intend Research, LLC | Norman | Oklahoma | 73069 | — |
| Heritage Valley Medical Group, Inc. | Beaver | Pennsylvania | 15009 | — |
| Preferred Primary Care Physicians | Uniontown | Pennsylvania | 15401 | — |
| Tribe Clinical Research, LLC | Greenville | South Carolina | 29607 | — |
| Dallas Diabetes Research Center | Dallas | Texas | 75230 | — |
| Diabetes and Thyroid Center of Fort Worth | Fort Worth | Texas | 76132 | — |
| Juno Research | Houston | Texas | 77040 | — |
| Biopharma Informatic, LLC | Houston | Texas | 77084 | — |
| North Hills Medical Research | North Richland Hills | Texas | 76180 | — |
| Texas Diabetes & Endocrinology, P.A. | Round Rock | Texas | 78681 | — |
| Clinical Trials of Texas, Inc. | San Antonio | Texas | 78229 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Martin Diagnostic Clinic | Tomball | Texas | 77375 | — |
| Rainier Clinical Research Center | Renton | Washington | 98057 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 95 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04537923, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 2, 2023 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04537923 live on ClinicalTrials.gov.