A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)
Public ClinicalTrials.gov record NCT04855747. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo- Controlled Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment of Major Depressive Disorder (The RELIANCE-II Study)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an outpatient, 2-arm, Phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of REL-1017 once daily (QD) as an adjunctive treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug or placebo for the duration of the treatment period.
Study identification
- NCT ID
- NCT04855747
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 236 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 30, 2021 (Actual)
- Primary completion
- Dec 31, 2024 (Actual)
- Completion
- Jan 14, 2025 (Actual)
- Last update posted
- Jul 10, 2026
2021 – 2025
United States locations
- U.S. sites
- 70
- U.S. states
- 28
- U.S. cities
- 62
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Relmada Site | Homewood | Alabama | 35209 | — |
| Relmada Site | Chandler | Arizona | 85226 | — |
| Relmada Site | Chandler | Arizona | 85286 | — |
| Relmada Site | Phoenix | Arizona | 85016 | — |
| Relmada Site | Tucson | Arizona | 85704 | — |
| Relmada Site | Bryant | Arkansas | 72022 | — |
| Relmada Site | Anaheim | California | 92805 | — |
| Relmada Site | Bellflower | California | 90706 | — |
| Relmada Site | Encino | California | 91316 | — |
| Relmada Site | Lafayette | California | 94549 | — |
| Relmada Site | Los Angeles | California | 90015 | — |
| Relmada Site | Newport Beach | California | 92660 | — |
| Relmada Site | Orange | California | 92868 | — |
| Relmada Site | Redlands | California | 92374 | — |
| Relmada Site | Santa Ana | California | 92705 | — |
| Relmada Site | Stanford | California | 94305 | — |
| Relmada Site | Temecula | California | 92591 | — |
| Relmada Site | Upland | California | 91786 | — |
| Relmada Site | Denver | Colorado | 80209 | — |
| Relmada Site | Brandon | Florida | 33511 | — |
| Relmada Site | Hialeah | Florida | 33015 | — |
| Relmada Site | Jacksonville | Florida | 32256 | — |
| Relmada Site | Maitland | Florida | 32751 | — |
| Relmada Site | Miami | Florida | 33122 | — |
| Relmada Site | Miami | Florida | 33125 | — |
| Relmada Site | Miami | Florida | 33133 | — |
| Relmada Site | Miami | Florida | 33136 | — |
| Relmada Site | Miami | Florida | 33174 | — |
| Relmada Site | Miami Springs | Florida | 33166 | — |
| Relmada Site | Okeechobee | Florida | 34972 | — |
| Relmada Site | Tampa | Florida | 33607 | — |
| Relmada Site | West Palm Beach | Florida | 33407 | — |
| Relmada Site | Savannah | Georgia | 31406 | — |
| Relmada Site | Boise | Idaho | 83704 | — |
| Relmada Site | Chicago | Illinois | 60611 | — |
| Relmada Site | Chicago | Illinois | 60634 | — |
| Relmada Site | Elgin | Illinois | 60123 | — |
| Relmada Site | Overland Park | Kansas | 66210 | — |
| Relmada Site | Marrero | Louisiana | 70072 | — |
| Relmada Site | Baltimore | Maryland | 21208 | — |
| Relmada Site | Bel Air | Maryland | 21015 | — |
| Relmada Site | Gaithersburg | Maryland | 20877 | — |
| Relmada Site | Boston | Massachusetts | 02131 | — |
| Relmada Site | Bloomfield Hills | Michigan | 48302 | — |
| Relmada Site | Mankato | Minnesota | 56001 | — |
| Relmada Site | Weldon Spring | Missouri | 63304 | — |
| Relmada Site | Las Vegas | Nevada | 89121 | — |
| Relmada Site | Toms River | New Jersey | 08755 | — |
| Relmada Site | Cedarhurst | New York | 11516 | — |
| Relmada Site | Monroe | North Carolina | 28112 | — |
| Relmada Site | Beachwood | Ohio | 44122 | — |
| Relmada Site | Cincinnati | Ohio | 45215 | — |
| Relmada Site | Cincinnati | Ohio | 45219 | — |
| Relmada Site | Westlake | Ohio | 44145 | — |
| Relmada Site | Philadelphia | Pennsylvania | 19104 | — |
| Relmada Site | State College | Pennsylvania | 16801 | — |
| Relmada Site | Memphis | Tennessee | 38119 | — |
| Relmada Site | Austin | Texas | 78737 | — |
| Relmada Site | Austin | Texas | 78759 | — |
| Relmada Site | Beaumont | Texas | 77702 | — |
| Relmada Site | Bellaire | Texas | 77401 | — |
| Relmada Site | Dallas | Texas | 75243 | — |
| Relmada Site | Friendswood | Texas | 77546 | — |
| Relmada Site | Houston | Texas | 77081 | — |
| Relmada Site | Sherman | Texas | 75092 | — |
| Relmada Site | Wichita Falls | Texas | 76309 | — |
| Relmada Site | Draper | Utah | 84020 | — |
| Relmada Site | Rutland | Vermont | 05701 | — |
| Relmada Site | Portsmouth | Virginia | 23703 | — |
| Relmada Site | Everett | Washington | 98201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04855747, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 10, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04855747 live on ClinicalTrials.gov.