A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin
Public ClinicalTrials.gov record NCT06045221. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-Label Study to Investigate the Efficacy and Safety of Once Daily Oral LY3502970 Compared With Oral Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin (ACHIEVE-3)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to assess efficacy and safety of orforglipron compared with oral semaglutide in participants with Type 2 diabetes and inadequate glycemic control with metformin.The study will last around 61 weeks.
Study identification
- NCT ID
- NCT06045221
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,698 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 22, 2023 (Actual)
- Primary completion
- Aug 22, 2025 (Actual)
- Completion
- Aug 22, 2025 (Actual)
- Last update posted
- Sep 15, 2026
2023 – 2025
United States locations
- U.S. sites
- 64
- U.S. states
- 28
- U.S. cities
- 61
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Absolute Clinical Research | Phoenix | Arizona | 85051 | — |
| San Fernando Valley Health Institute | Canoga Park | California | 91304 | — |
| Neighborhood Healthcare Institute of Health | Escondido | California | 92025 | — |
| Velocity Clinical Research, Gardena | Gardena | California | 90247 | — |
| Biopharma Informatic, LLC | Los Angeles | California | 90035 | — |
| Velocity Clinical Research, Westlake | Los Angeles | California | 90057 | — |
| Infinity Clinical Research - Norco | Norco | California | 92860 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Norcal Endocrinology & Internal Medicine | San Ramon | California | 94583 | — |
| Encompass Clinical Research | Spring Valley | California | 91978 | — |
| University Clinical Investigators, Inc. | Tustin | California | 92780 | — |
| New West Physicians Clinical Research | Golden | Colorado | 80401 | — |
| Connecticut Clinical Research - Cromwell | Cromwell | Connecticut | 06416 | — |
| Clinical Research of West Florida, Inc. (Clearwater) | Clearwater | Florida | 33765 | — |
| South Florida Clinical Research Institute | Margate | Florida | 33063 | — |
| Miami Dade Medical Research Institute, LLC | Miami | Florida | 33176 | — |
| West Orange Endocrinology | Ocoee | Florida | 34761 | — |
| Latin Clinical Trial Center Florida | Tamarac | Florida | 33321 | — |
| Clinical Research of West Florida | Tampa | Florida | 33606 | — |
| Metabolic Research Institute, Inc. | West Palm Beach | Florida | 33401 | — |
| Balanced Life Health Care Solutions/SKYCRNG | Lawrenceville | Georgia | 30046 | — |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| Northwest Clinical Trials | Boise | Idaho | 83704 | — |
| Family First Medical Center | Idaho Falls | Idaho | 83404 | — |
| American Health Network of Indiana, LLC - Greenfield | Greenfield | Indiana | 46140 | — |
| Velocity Clinical Research, Valparaiso | Valparaiso | Indiana | 46383 | — |
| Cotton O'Neil Diabetes & Endocrinology | Topeka | Kansas | 66606 | — |
| Tekton Research, Inc | Wichita | Kansas | 67218 | — |
| DelRicht Research | New Orleans | Louisiana | 70115 | — |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| Revival Research Institute, LLC | Dearborn | Michigan | 48126 | — |
| SKY Integrative Medical Center/SKYCRNG | Ridgeland | Mississippi | 39157 | — |
| Kansas City Research Institute | Kansas City | Missouri | 64131 | — |
| Logan Health Research | Kalispell | Montana | 59901 | — |
| Wr-Crcn, Llc | Las Vegas | Nevada | 89106 | — |
| Premier Research | Trenton | New Jersey | 08611 | — |
| Albany Medical College, Division of Community Endocrinology | Albany | New York | 12203 | — |
| Ellipsis Research Group - Brooklyn - 7th Street | Brooklyn | New York | 11215 | — |
| Great Lakes Medical Research, LLC | Westfield | New York | 14787 | — |
| PharmQuest Life Sciences, LLC | Greensboro | North Carolina | 27408 | — |
| Lucas Research, Inc | Morehead City | North Carolina | 28557 | — |
| Accellacare - Piedmont | Statesville | North Carolina | 28625 | — |
| Wake Forest University Baptist Medical Center (WFUBMC) | Winston-Salem | North Carolina | 27104 | — |
| Aventiv Research Inc | Columbus | Ohio | 43213 | — |
| Tekton Research, Inc | Moore | Oklahoma | 73160 | — |
| Alliance for Multispecialty Research, LLC | Norman | Oklahoma | 73069 | — |
| The Corvallis Clinic, P.C. | Corvallis | Oregon | 97330 | — |
| Heritage Valley Medical Group, Inc. | Beaver | Pennsylvania | 15009 | — |
| Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18) | Pittsburgh | Pennsylvania | 15236 | — |
| The Research Center of The Upstate | Greenville | South Carolina | 29607 | — |
| New Phase Research and Development | Knoxville | Tennessee | 37909 | — |
| Clinical Neuroscience Solutions Inc. | Memphis | Tennessee | 38119 | — |
| Velocity Clinical Research, Austin | Austin | Texas | 78759 | — |
| Velocity Clinical Research, Dallas | Dallas | Texas | 75230 | — |
| Diabetes and Thyroid Center of Ft. Worth | Fort Worth | Texas | 76132 | — |
| Juno Research | Houston | Texas | 77040 | — |
| Endocrine Ips, Pllc | Houston | Texas | 77079 | — |
| Clear Brook Medical Associates | Houston | Texas | 77089 | — |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | — |
| Texas Valley Clinical Research | Weslaco | Texas | 78596 | — |
| Synexus Clinical Research US, Inc. | Salt Lake City | Utah | 84106 | — |
| Eastside Research Associates | Redmond | Washington | 98052 | — |
| Rainier Clinical Research Center | Renton | Washington | 98057 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 67 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06045221, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 15, 2026 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06045221 live on ClinicalTrials.gov.