A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin and/or SGLT-2 Inhibitor
Public ClinicalTrials.gov record NCT06109311. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind Study to Investigate the Efficacy and Safety of Once Daily Oral Orforglipron Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin and/or SGLT-2 Inhibitor
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to determine the safety and efficacy of orforglipron. Participants will have Type 2 Diabetes (T2D) and have inadequate glycemic control with insulin glargine with or without metformin and/or SGLT-2 (sodium-glucose cotransporter-2) inhibitor. The study will last about 46 weeks and may include up to 20 visits.
Study identification
- NCT ID
- NCT06109311
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 546 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 10, 2023 (Actual)
- Primary completion
- Sep 15, 2025 (Actual)
- Completion
- Sep 15, 2025 (Actual)
- Last update posted
- Oct 1, 2026
2023 – 2025
United States locations
- U.S. sites
- 25
- U.S. states
- 16
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| MD First Research - Chandler | Chandler | Arizona | 85286 | — |
| Phoenix Clinical LLC | Phoenix | Arizona | 85014 | — |
| SanRo Clinical Research Group | Bryant | Arkansas | 72022 | — |
| Velocity Clinical Research, Gardena | Gardena | California | 90247 | — |
| Loma Linda University Health System | Loma Linda | California | 92350 | — |
| Western University of Health Sciences | Pomona | California | 91766 | — |
| Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc. | Toluca Lake | California | 91602 | — |
| CMR of Greater New Haven, LLC | Hamden | Connecticut | 06517 | — |
| Care Access - Brandon | Brandon | Florida | 33510 | — |
| Encore Medical Research | Hollywood | Florida | 33024 | — |
| Encore Medical Research - Weston | Weston | Florida | 33331 | — |
| Orita Clinical Research | Decatur | Georgia | 30034 | — |
| Bingham Memorial Hospital | Blackfoot | Idaho | 83221 | — |
| St. Luke's Humphreys Diabetes Center: Boise | Boise | Idaho | 83702 | — |
| Cotton O'Neil Diabetes & Endocrinology | Topeka | Kansas | 66606 | — |
| The Research Group of Lexington | Lexington | Kentucky | 40503 | — |
| Clinvest Headlands Llc | Springfield | Missouri | 65807 | — |
| Richmond University Medical Center | Staten Island | New York | 10310 | — |
| Velocity Clinical Research, Mt. Auburn | Cincinnati | Ohio | 45219 | — |
| Velocity Clinical Research, Medford | Medford | Oregon | 97504 | — |
| Tristar Clinical Investigations | Philadelphia | Pennsylvania | 19114 | — |
| Frontier Clinical Research, LLC | Scottdale | Pennsylvania | 15683 | — |
| Lifedoc Research - Lenox Park Drive | Memphis | Tennessee | 38115 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Texas Valley Clinical Research | Weslaco | Texas | 78596 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 45 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06109311, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 1, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06109311 live on ClinicalTrials.gov.