A Study of Orforglipron (LY3502970) Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin
Public ClinicalTrials.gov record NCT06192108. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-Label Study to Investigate the Efficacy and Safety of Once Daily Oral Orforglipron Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin (ACHIEVE-2)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to assess the safety and efficacy of orforglipron compared with dapagliflozin in improving blood sugar control in participants with type 2 diabetes (T2D) with inadequate glycemic control using metformin. The study will last approximately 46 weeks.
Study identification
- NCT ID
- NCT06192108
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 962 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 10, 2024 (Actual)
- Primary completion
- Sep 26, 2025 (Actual)
- Completion
- Sep 26, 2025 (Actual)
- Last update posted
- Oct 16, 2026
2024 – 2025
United States locations
- U.S. sites
- 19
- U.S. states
- 13
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alliance Research Institute - Canoga Park | Canoga Park | California | 91304 | — |
| Ark Clinical Research | Long Beach | California | 90815 | — |
| Collaborative Neuroscience Research, LLC | Los Alamitos | California | 90720 | — |
| Wolverine Clinical Trials | Santa Ana | California | 92706 | — |
| CMR of Greater New Haven, LLC | Hamden | Connecticut | 06517 | — |
| Institute of Endocrinology Diabetes, Health & Hormone | Stockbridge | Georgia | 30281 | — |
| Elite Clinical Trials | Rexburg | Idaho | 83440 | — |
| Accellacare - DuPage | Lombard | Illinois | 60148 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| St. Vincent Healthcare | Billings | Montana | 59101 | — |
| Albuquerque Clinical Trials, Inc. | Albuquerque | New Mexico | 87102 | — |
| Accellacare - Winston-Salem | Winston-Salem | North Carolina | 27103 | — |
| Alliance for Multispecialty Research, LLC | Norman | Oklahoma | 73069 | — |
| Essential Medical Research | Tulsa | Oklahoma | 74137 | — |
| Accellacare - Mt Pleasant | Mt. Pleasant | South Carolina | 29464 | — |
| Accellacare, US Inc., d/b/a Accellacare of Knoxville | Jefferson City | Tennessee | 37760 | — |
| Velocity Clinical Research, Dallas | Dallas | Texas | 75230 | — |
| Juno Research | Houston | Texas | 77040 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 55 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06192108, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 16, 2026 · Synced Oct 29, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06192108 live on ClinicalTrials.gov.