ClinicalTrials.gov record
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor
ClinicalTrials.gov ID: NCT06221969
Public ClinicalTrials.gov record NCT06221969. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of Co-administered Cagrilintide and Semaglutide (CagriSema) 2.4 mg/2.4 mg s.c. Once Weekly Versus Tirzepatide 15 mg s.c. Once Weekly in Participants With Type 2 Diabetes Inadequately Controlled on Metformin With or Without an SGLT2 Inhibitor
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will look at how well CagriSema helps people with type 2 diabetes lower their blood sugar and body weight. CagriSema is a new investigational medicine. Doctors may not yet prescribe CagriSema. CagriSema will be compared to a medicine called tirzepatide that doctors may prescribe in some countries. Participants will get either CagriSema or tirzepatide. Which treatment participant get is decided by chance like flipping a coin. Participant will have an equal chance of receiving either drug. For each participant, the study will last for up to one and a half years.
Study identification
- NCT ID
- NCT06221969
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,024 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 16, 2024 (Actual)
- Primary completion
- Mar 4, 2026 (Actual)
- Completion
- Apr 6, 2026 (Actual)
- Last update posted
- Sep 4, 2026
2024 – 2026
United States locations
- U.S. sites
- 117
- U.S. states
- 34
- U.S. cities
- 99
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Synexus Clin Res-Birmingham | Birmingham | Alabama | 35211 | — |
| Univ of Alabama_Birmingham | Birmingham | Alabama | 35233 | — |
| Prime Medical Group, LLC | Gilbert | Arizona | 85296 | — |
| Velocity Clinical Research-Phoenix | Phoenix | Arizona | 85006 | — |
| Synexus Rsch /Cnt Phnx Med C | Phoenix | Arizona | 85020 | — |
| Arkansas Clinical Research | Little Rock | Arkansas | 72205 | — |
| Unity Health-Searcy Medical Center | Searcy | Arkansas | 72143 | — |
| Velocity Clin Res-Chula Vista | Chula Vista | California | 91911 | — |
| Headlands Research California, LLC | Escondido | California | 92025 | — |
| Neighborhood Healthcare | Escondido | California | 92025 | — |
| St. Jude Heritage Yorba Linda - Pediatric Ste D | Fullerton | California | 92835 | — |
| Diabetes & Endocrine Specialists - La Mesa | La Mesa | California | 91942 | — |
| Diabetes and Endocrine Specialists - La Mesa | La Mesa | California | 91942 | — |
| Velocity Clin Res San Diego | La Mesa | California | 91942 | — |
| Headlands Research CTR Lincoln | Lincoln | California | 95648 | — |
| Loma Linda Univ Hlth Cr Endo | Loma Linda | California | 92354 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Desert Oasis Healthcare | Palm Springs | California | 92262 | — |
| Velocity Clin Res - Panorama | Panorama City | California | 91402 | — |
| Western University of Health Sciences | Pomona | California | 91766 | — |
| Endocrinology Josel Cabaccan | San Jose | California | 95148 | — |
| Mills-Peninsula Medical Center | San Mateo | California | 94401 | — |
| NorCal Endocrinology and Internal Medicine | San Ramon | California | 94583 | — |
| Premier Medical Center, Inc. | Toluca Lake | California | 91602 | — |
| Velocity Clin Res - Panorama | Van Nuys | California | 91405 | — |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Optumcare Clinical Trials,LLC-Golden | Colorado Springs | Colorado | 80906 | — |
| Northeast Res Inst. Inc. | Jacksonville | Florida | 32204 | — |
| Bioclinical Research Alliance | Miami | Florida | 33155 | — |
| New Horizon Research Center | Miami | Florida | 33165 | — |
| South Broward Research LLC | Miramar | Florida | 33027 | — |
| West Orange Endocrinology | Ocoee | Florida | 34761 | — |
| Optimal Research Sites | Orange City | Florida | 32763 | — |
| Trans Res Inst for Met & Diab | Orlando | Florida | 32804 | — |
| Oviedo Medical Research, LLC | Oviedo | Florida | 32765 | — |
| Center for Diab,Obes & Metab | Pembroke Pines | Florida | 33024 | — |
| Hope Clin Res & Wellness | Conyers | Georgia | 30094 | — |
| Center for Adv Res & Education | Gainesville | Georgia | 30501 | — |
| Urban Family Practice Assoc | Marietta | Georgia | 30067 | — |
| Endocrine Research Solutions | Roswell | Georgia | 30076 | — |
| Pacific Diabetes & Endo Ctr | Honolulu | Hawaii | 96813 | — |
| St. Luke's Health System | Boise | Idaho | 83702 | — |
| Solaris Clinical Research | Meridian | Idaho | 83646 | — |
| Cedar-Crosse Research Center | Chicago | Illinois | 60607 | — |
| Clinical Invest Special_Gurnee | Gurnee | Illinois | 60031 | — |
| Endeavor Health | Skokie | Illinois | 60077 | — |
| Evanston Premier Hlthcr Res | Skokie | Illinois | 60077 | — |
| American Health Network of Indiana, LLC_Greenfield | Greenfield | Indiana | 46140 | — |
| Iowa Diabetes & Endo Res Ctr | West Des Moines | Iowa | 50266 | — |
| Cotton-O'Neil Diab & Endo Ctr | Topeka | Kansas | 66606 | — |
| Velocity Clin Res Lafayette | Lafayette | Louisiana | 70508 | — |
| MedStar Hlth Res Institute | Hyattsville | Maryland | 20782 | — |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| International Diabetes Center | Minneapolis | Minnesota | 55416 | — |
| Belzoni Clinical Research | Belzoni | Mississippi | 39038 | — |
| Velocity Clin Res Gulfport | Gulfport | Mississippi | 39503 | — |
| Diabetes & Endo Specialists Inc | Chesterfield | Missouri | 63017 | — |
| StudyMetrix Research LLC | City of Saint Peters | Missouri | 63303 | — |
| Amicis Centers of Clinical Research | St Louis | Missouri | 63128 | — |
| Velocity Clin Res Albuquerque | Albuquerque | New Mexico | 87107 | — |
| AMC Community Endocrinology | Albany | New York | 12203 | — |
| Velocity Clin Res Syracuse | East Syracuse | New York | 13057 | — |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | — |
| UNC Eastowne Clinical Research Unit | Chapel Hill | North Carolina | 27514 | — |
| PharmQuest Life Sciences LLC | Greensboro | North Carolina | 27408 | — |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | — |
| Centricity Rsrch MHCity Multi | Morehead City | North Carolina | 28557 | — |
| Piedmont Healthcare/Research | Statesville | North Carolina | 28625 | — |
| Accellacare | Wilmington | North Carolina | 28401 | — |
| Plains Clinical Research Center, LLC | Fargo | North Dakota | 58104 | — |
| Remington Davis Inc | Columbus | Ohio | 43215 | — |
| Advanced Medical Research | Maumee | Ohio | 43537 | — |
| New Venture Medical Research | Wadsworth | Ohio | 44281-9236 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73072 | — |
| CCT Research | Horsham | Pennsylvania | 19044 | — |
| Thomas Jefferson University_Philadelphia | Philadelphia | Pennsylvania | 19114 | — |
| Clinical Res Collaborative | Cumberland | Rhode Island | 02864 | — |
| Velocity Clin Res Providence | East Greenwich | Rhode Island | 02818 | — |
| Velocity Clinical Res-Anderson | Anderson | South Carolina | 29621 | — |
| Trial Management Associates | Myrtle Beach | South Carolina | 29572 | — |
| Hillcrest Clinical Research | Simpsonville | South Carolina | 29681-1538 | — |
| Spartanburg Medical Research | Spartanburg | South Carolina | 29303 | — |
| AM Diabetes And Endocrinology Center | Bartlett | Tennessee | 38133 | — |
| Holston Medical Group Pc | Bristol | Tennessee | 37620 | — |
| Univ Diab & Endo Consultants | Chattanooga | Tennessee | 37411 | — |
| Jackson Clinic | Jackson | Tennessee | 38305 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Clinical Neuroscience Solutions | Memphis | Tennessee | 38119 | — |
| HealthStar Physicians PC | Morristown | Tennessee | 37813 | — |
| Clinical Research Associates | Nashville | Tennessee | 37203 | — |
| Arlington Family Res. Ctr Inc | Arlington | Texas | 76012-4637 | — |
| Velocity Clin Res | Austin | Texas | 78759 | — |
| UT Health University of Texas | Bellaire | Texas | 77401 | — |
| Velocity Clin Res, Dallas | Dallas | Texas | 75230 | — |
| North Texas Endocrine Center | Dallas | Texas | 75231 | — |
| Synexus Clin Res Dallas | Dallas | Texas | 75234 | — |
| Cedar Health Research | Dallas | Texas | 75251 | — |
| PrimeCare Medical Group | Houston | Texas | 77024 | — |
| JCCT- Juno NW Houston | Houston | Texas | 77040 | — |
| Discovery MM Services, Inc | Houston | Texas | 77061 | — |
| PlanIt Research, PLLC | Houston | Texas | 77079 | — |
| Amir Ali Hassan, MD, PA | Houston | Texas | 77089 | — |
| Fmc Science, Llc | Lampasas | Texas | 76550 | — |
| Quality Clinical Research, Inc. | San Antonio | Texas | 78209 | — |
| University of Texas San Antonio | San Antonio | Texas | 78229 | — |
| NE Clin Res of San Antonio | San Antonio | Texas | 78233 | — |
| University of Texas San Antonio | San Antonio | Texas | 78284 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Mt Olympus Medical Research, LLC | Sugar Land | Texas | 77478 | — |
| DM Clin Rsrch/Fam Diag Clinic | Tomball | Texas | 77375 | — |
| Foothill Family Clinic South | Salt Lake City | Utah | 84121 | — |
| J.Lewis Research Inc | South Jordan | Utah | 84095 | — |
| Velocity Clin Res-Salt Lk City | West Jordan | Utah | 84088 | — |
| TPMG Clinical Research | Newport News | Virginia | 23606 | — |
| Rainier Clin Res Ctr Inc | Renton | Washington | 98057 | — |
| Prevea Health | Green Bay | Wisconsin | 54303 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 80 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06221969, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 4, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06221969 live on ClinicalTrials.gov.