A Study on the Safety and Immunogenicity of Hexavalent Influenza mRNA Vaccine in Adult Participants 50 Years of Age and Older
Public ClinicalTrials.gov record NCT06744205. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I/II, Randomized, Modified Double-blind Study to Investigate the Safety and Immunogenicity of Different Doses of Hexavalent Influenza mRNA HA + mRNA NA Vaccine in Adult Participants 50 Years of Age and Older
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular injection of different formulations of a hexavalent influenza messenger ribonucleic acid (mRNA) vaccine composed of differing dose levels of trivalent (TIV) mRNA hemagglutinin (HA) in combination with TIV mRNA-neuraminidase (NA) compared to an active control ((Fluzone standard-dose quadrivalent influenza vaccine (QIV-SD) or Fluzone high-dose quadrivalent influenza vaccine (QIV-HD) in adults 50 years of age and older.
Study identification
- NCT ID
- NCT06744205
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 1,162 participants
Conditions and interventions
Conditions
Interventions
- Trivalent (TIV) messenger ribonucleic acid (mRNA) hemagglutinin (HA) Vaccine 1 Biological
- TIV mRNA-neuraminidase (NA) Biological
- TIV mRNA-HA Vaccine 2 Biological
- Quadrivalent Influenza Standard Dose Vaccine Biological
- Quadrivalent Influenza Vaccine High Dose Biological
Biological
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 6, 2025 (Actual)
- Primary completion
- May 22, 2026 (Actual)
- Completion
- May 22, 2026 (Actual)
- Last update posted
- Jun 9, 2026
2025 – 2026
United States locations
- U.S. sites
- 21
- U.S. states
- 14
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Accel Research Sites Network - Birmingham- Site Number : 8400008 | Birmingham | Alabama | 35216 | — |
| AMR Mobile- Site Number : 8400022 | Mobile | Alabama | 36608 | — |
| Alliance for Multispeciality Research - Clinical Research Consortium- Site Number : 8400015 | Tempe | Arizona | 85281 | — |
| AMR Miami- Site Number : 8400021 | Coral Gables | Florida | 33134 | — |
| Accel Research Sites Network - DeLand Clinical Research Unit- Site Number : 8400003 | DeLand | Florida | 32720 | — |
| Alliance for Multispeciality Research - Fort Myers- Site Number : 8400013 | Fort Myers | Florida | 33912 | — |
| Accel Research Sites - Maitland- Site Number : 8400007 | Maitland | Florida | 32751 | — |
| Innovation Medical Research Center - Palmetto Bay- Site Number : 8400011 | Palmetto Bay | Florida | 33157 | — |
| Accel Research Site - NeuroStudies.net, LLC - ERN - PPDS- Site Number : 8400001 | Decatur | Georgia | 30030-2627 | — |
| AMR - Chicago- Site Number : 8400012 | Oak Brook | Illinois | 60532 | — |
| Alliance for Multispeciality Research - Newton- Site Number : 8400020 | Newton | Kansas | 67114 | — |
| Alliance for Multispeciality Research - Wichita East- Site Number : 8400014 | Wichita | Kansas | 67207 | — |
| Alliance for Multispeciality Research - Lexington- Site Number : 8400018 | Lexington | Kentucky | 40509 | — |
| Boston Clinical Trials- Site Number : 8400009 | Boston | Massachusetts | 02131 | — |
| ActivMed Practices & Research- Site Number : 8400005 | Methuen | Massachusetts | 03110 | — |
| Quest Research Institute- Site Number : 8400010 | Farmington Hills | Michigan | 48334 | — |
| Alliance for Multispeciality Research - Kansas City- Site Number : 8400019 | Kansas City | Missouri | 64114 | — |
| AMR Las Vegas - Site Number : 8400016 | Las Vegas | Nevada | 89119 | — |
| Coastal Carolina Research Center - North Charleston- Site Number : 8400002 | North Charleston | South Carolina | 29405 | — |
| Alliance for Multispeciality Research - Knoxville- Site Number : 8400017 | Knoxville | Tennessee | 37920 | — |
| Charlottesville Medical Research- Site Number : 8400004 | Charlottesville | Virginia | 22911 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06744205, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 9, 2026 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06744205 live on ClinicalTrials.gov.