A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
Public ClinicalTrials.gov record NCT07621237. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy, Safety, and Tolerability of TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this clinical trial is to learn if a drug called TNX-102 SL works to treat moderate to severe major depressive disorder in adults. It will also learn about the safety of TNX-102 SL. The main questions it aims to answer are: Does TNX-102 SL improve depression symptoms according to a depression symptom rating scale? What medical problems do participants have when taking TNX-102 SL? Researchers will compare TNX-102 SL to a placebo (a look-alike substance that contains no drug) to see if TNX-102 SL works to treat major depressive disorder. Participants will: Take TNX-102 SL or a placebo every night at bedtime for 6 weeks Visit the clinic once every 2 weeks for checkups and tests
Study identification
- NCT ID
- NCT07621237
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 360 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 31, 2026
- Primary completion
- Jan 31, 2028
- Completion
- Jan 31, 2028
- Last update posted
- Jun 1, 2026
2026 – 2028
United States locations
- U.S. sites
- 25
- U.S. states
- 14
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| IMA Clinical Research- Phoenix | Phoenix | Arizona | 85012 | Not yet recruiting |
| Inland Psychiatric Medical Group, Inc. - Chino | Chino | California | 91710 | Not yet recruiting |
| Synergy Research - San Diego | Lemon Grove | California | 91945 | Not yet recruiting |
| Nrc Research Institute | Orange | California | 92868 | Not yet recruiting |
| Artemis Institute For Clinical Research - San Diego | San Diego | California | 92123 | Not yet recruiting |
| Sunwise Clinical Research, Llc | Walnut Creek | California | 94596 | Not yet recruiting |
| Clinical Neuroscience Solutions Inc. - Jacksonville | Jacksonville | Florida | 32256 | Not yet recruiting |
| K2 Medical Research - Maitland | Maitland | Florida | 32751 | Not yet recruiting |
| Central Miami Medical Institute Llc. | Miami | Florida | 33125 | Not yet recruiting |
| Medical Research Group of Central Florida | Orange City | Florida | 32763 | Not yet recruiting |
| Clinical Neuroscience Solutions Inc. - Orlando | Orlando | Florida | 32801 | Recruiting |
| K2 Medical Research - Tampa | Tampa | Florida | 33634 | Not yet recruiting |
| Evergreen Clinical Trials | Norcross | Georgia | 30092 | Not yet recruiting |
| Chicago Research Center | Chicago | Illinois | 60634 | Not yet recruiting |
| Delricht Research - New Orleans | New Orleans | Louisiana | 70115 | Recruiting |
| Delricht Research - Rockville | Rockville | Maryland | 20852 | Not yet recruiting |
| Activmed Practices & Research, Llc - Methuen | Methuen | Massachusetts | 01844 | Not yet recruiting |
| Redbird Research | Las Vegas | Nevada | 89119 | Not yet recruiting |
| Ima Clinical Research - Nyc Midtown | New York | New York | 10036 | Not yet recruiting |
| Coastal Carolina Research Center | North Charleston | South Carolina | 29405 | Not yet recruiting |
| Clinical Neuroscience Solutions Inc. - Memphis | Mephis | Tennessee | 38119 | Not yet recruiting |
| Austin Clinical Trial Partners | Austin | Texas | 78737 | Not yet recruiting |
| Revival Research Institute, Llc - McKinney, Tx | McKinney | Texas | 75071 | Not yet recruiting |
| Delricht Research - Plano | Plano | Texas | 75024 | Not yet recruiting |
| Boeson Research Pvu | Provo | Utah | 84604 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07621237, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 1, 2026 · Synced Sep 1, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07621237 live on ClinicalTrials.gov.