ClinicalTrials.gov record
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
ClinicalTrials.gov ID: NCT07797335
Public ClinicalTrials.gov record NCT07797335. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of Zenagamtide s.c. Once Weekly Compared to Insulin Glargine s.c. Once Daily in Participants With Type 2 Diabetes and Increased Cardiovascular Risk Inadequately Controlled on 1-3 Oral Glucose-lowering Medications (AMBITION 7)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is being conducted to find out how well zenagamtide works and how safe it is compared to insulin glargine in participants with type 2 diabetes who are at higher risk of heart and blood vessel problems and are already taking 1 to 3 diabetes medications. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get zenagamtide, (the treatment being tested) or insulin glargine (a comparator) and which treatment participants get is decided by chance.
Study identification
- NCT ID
- NCT07797335
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,778 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 45 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 23, 2026
- Primary completion
- Jul 30, 2028
- Completion
- Sep 19, 2028
- Last update posted
- Aug 31, 2026
2026 – 2028
United States locations
- U.S. sites
- 109
- U.S. states
- 28
- U.S. cities
- 94
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Univ of Alabama Birmingham | Birmingham | Alabama | 35294 | Not yet recruiting |
| Eastern Shore Rsrch Inst, LLC | Fairhope | Alabama | 36532 | Recruiting |
| Chambliss Clinical Trials, LLC | Montgomery | Alabama | 36106 | Recruiting |
| Honor Health | Scottsdale | Arizona | 85258 | Not yet recruiting |
| First Valley Medical Group | Lancaster | California | 93534 | Recruiting |
| Headlands Research CTR Lincoln | Lincoln | California | 95648 | Recruiting |
| Torrance Clin Res Inst, Inc. | Lomita | California | 90717 | Recruiting |
| Pacific Clinical Studies | Los Alamitos | California | 90720 | Recruiting |
| VAGLAHS Clinical Research Center (CRC) | Los Angeles | California | 90073 | Not yet recruiting |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | Recruiting |
| Paradigm Clinical Research | San Diego | California | 92108 | Recruiting |
| N America Res Inst - San Dimas | San Dimas | California | 91773 | Recruiting |
| Encompass Clinical Research_Spring Valley | Spring Valley | California | 91978 | Recruiting |
| Innovative Research of W FL | Clearwater | Florida | 33756 | Recruiting |
| Nature Coast Clin Rsrch_Crystal River | Crystal River | Florida | 34429 | Not yet recruiting |
| Florida Premier Cardiology | Delray Beach | Florida | 33484 | Not yet recruiting |
| Encore Medical Research LLC | Hollywood | Florida | 33024 | Recruiting |
| East Coast Institute For Research | Jacksonville | Florida | 32216 | Not yet recruiting |
| Jacksonville Ctr for Clin Res | Jacksonville | Florida | 32216 | Not yet recruiting |
| Clinical Research of Cent FL | Lakeland | Florida | 33805 | Recruiting |
| Life Spring Research Foundation LLC | Miami | Florida | 33130 | Recruiting |
| Optimus U, Corp | Miami | Florida | 33135 | Not yet recruiting |
| Flourish Research - North Miami | Miami | Florida | 33138 | Not yet recruiting |
| Inpatient Research Clinic LLC | Miami Lakes | Florida | 33014 | Not yet recruiting |
| San Marcus Res Clin Miami Lakes | Miami Lakes | Florida | 33014 | Recruiting |
| Trujillo Medical Centers | Miramar | Florida | 33027 | Recruiting |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | Not yet recruiting |
| Ocala Cardiovascular Research | Ocala | Florida | 34471 | Recruiting |
| Suncoast Clinical Research, Inc. | Palm Harbor | Florida | 34684 | Not yet recruiting |
| Suncoast Research Associates LLC | Pembroke Pines | Florida | 33024 | Not yet recruiting |
| St Johns Center for Clin. Res | Saint Augustine | Florida | 32086 | Recruiting |
| Javara/Privia Med Grp GA,LLC | Albany | Georgia | 31707 | Recruiting |
| David Kavtaradze MD, Inc. | Cordele | Georgia | 31015 | Not yet recruiting |
| Atlanta Heart Specialist | Tucker | Georgia | 30084 | Not yet recruiting |
| Rocky Mountain Diab&Osteo Ctr | Idaho Falls | Idaho | 83404 | Recruiting |
| Elevate Clinical Research | Gurnee | Illinois | 60031 | Recruiting |
| Chicago Medical Research LLC | Hazel Crest | Illinois | 60429 | Recruiting |
| Genesis Orthopedics & Sports Medicine | Oak Brook | Illinois | 60523 | Not yet recruiting |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | Not yet recruiting |
| American Health Network of IN LLC_Franklin | Franklin | Indiana | 46131 | Not yet recruiting |
| American Health Network of Indiana, LLC_Greenfield | Greenfield | Indiana | 46140 | Not yet recruiting |
| American Health Network of IN LLC | Muncie | Indiana | 47304 | Not yet recruiting |
| West Broadway Clinic | Council Bluffs | Iowa | 51501 | Recruiting |
| University of Iowa Prev Inter Ctr | Iowa City | Iowa | 52772 | Not yet recruiting |
| Iowa Diab & Endo Res Center | West Des Moines | Iowa | 50266 | Not yet recruiting |
| Cotton O'Neil Diab & Endo Ctr | Topeka | Kansas | 66606 | Recruiting |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | Recruiting |
| Louisiana Heart Center | Covington | Louisiana | 70433 | Not yet recruiting |
| Ascension Saint Agnes Heart Ca | Baltimore | Maryland | 21229 | Not yet recruiting |
| MedStar Good Samaritan Hosp | Baltimore | Maryland | 21239 | Not yet recruiting |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115 | Not yet recruiting |
| Henry Ford Health System | Detroit | Michigan | 48202 | Not yet recruiting |
| Elite Research Center | Flint | Michigan | 48532 | Recruiting |
| Arcturus Healthcare, PLC. | Troy | Michigan | 48098 | Recruiting |
| Trinity Health Michigan Heart | Ypsilanti | Michigan | 48197 | Not yet recruiting |
| Johnson County ClinTrials | Kansas City | Missouri | 64112 | Not yet recruiting |
| Amicis Centers of Clinical Research | St Louis | Missouri | 63128 | Recruiting |
| Methodist Phys. Clinic | Omaha | Nebraska | 68114 | Recruiting |
| Palm Research Center Inc-Vegas | Las Vegas | Nevada | 89128 | Not yet recruiting |
| Central New York Clinical Research CNYCR | Manlius | New York | 13104 | Not yet recruiting |
| Mid Hudson Med Res-New Windsor | New Windsor | New York | 12553 | Recruiting |
| Harlem Cardiology_Madison ave | New York | New York | 10035 | Not yet recruiting |
| NYC Health + Hospitals/Lincoln | The Bronx | New York | 10451 | Not yet recruiting |
| Prime Global Research Inc. | The Bronx | New York | 10456 | Recruiting |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | Not yet recruiting |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | Recruiting |
| Piedmont Healthcare/Research | Statesville | North Carolina | 28625 | Recruiting |
| Accellacare | Winston-Salem | North Carolina | 27103 | Recruiting |
| Univ of Cincinnati Med Cent | Cincinnati | Ohio | 45267 | Not yet recruiting |
| Advanced Med Res Maumee | Maumee | Ohio | 43537 | Recruiting |
| Lynn Institute of Norman | Norman | Oklahoma | 73072 | Recruiting |
| Heritage Valley Medical Group | Beaver | Pennsylvania | 15009 | Not yet recruiting |
| Capital Area Research LLC | Newport | Pennsylvania | 17074 | Recruiting |
| Piedmont Research Partners, LLC | Fort Mill | South Carolina | 29707 | Recruiting |
| Accellacare US Inc._SC | Mt. Pleasant | South Carolina | 29464 | Not yet recruiting |
| Trial Management Associates | Myrtle Beach | South Carolina | 29572 | Recruiting |
| Holston Medical Group Pc | Bristol | Tennessee | 37620-7352 | Recruiting |
| The Alliance for Multispecialty Research LLC AMR | Knoxville | Tennessee | 37909 | Not yet recruiting |
| MidState Endocrine Associates | Nashville | Tennessee | 37203 | Recruiting |
| PharmaTex Research | Amarillo | Texas | 79106 | Not yet recruiting |
| Pinnacle Clinical Research | Austin | Texas | 78757 | Not yet recruiting |
| Javara Inc. / Privia Medical Group Gulf Coast PLLC | Conroe | Texas | 77384 | Recruiting |
| Osvaldo A. Brusco MD | Corpus Christi | Texas | 78414 | Not yet recruiting |
| Thyroid Endocrinology & Diabetes PA | Dallas | Texas | 75208 | Recruiting |
| Baylor Jack and Jane Hamilton | Dallas | Texas | 75226 | Not yet recruiting |
| Diabetes and Thyroid Ctr of FW | Fort Worth | Texas | 76132 | Not yet recruiting |
| PrimeCare Medical Group | Houston | Texas | 77024 | Recruiting |
| JCCT- Juno NW Houston | Houston | Texas | 77040 | Recruiting |
| Biopharma Informatic_Houston | Houston | Texas | 77043 | Recruiting |
| Northwest Houston Cardiology, P.A. | Houston | Texas | 77070 | Recruiting |
| Endocrine And Psychiatry Center | Houston | Texas | 77095 | Not yet recruiting |
| Prem Internal Med Asso Houston | Katy | Texas | 77493 | Recruiting |
| DCOL Ctr for Clin Res | Longview | Texas | 75605 | Recruiting |
| Texas Inst, Kdny & Endo Disor | Lufkin | Texas | 75904 | Recruiting |
| PRX Research | Mesquite | Texas | 75149 | Not yet recruiting |
| Clinical Advancement Center | San Antonio | Texas | 78212 | Recruiting |
| The IMA Group IMA Clinical Trials of America Inc. CTA | San Antonio | Texas | 78229 | Not yet recruiting |
| Univ Of Texas Hlth Science Cntr | San Antonio | Texas | 78229 | Not yet recruiting |
| VIP Trials | San Antonio | Texas | 78230 | Recruiting |
| NE Clin Res of San Antonio | San Antonio | Texas | 78233 | Recruiting |
| Simcare Medical Research, LLC | Sugar Land | Texas | 77478 | Recruiting |
| Valley Diab. & Endo Comp Ctr | Weslaco | Texas | 78596 | Not yet recruiting |
| Progressive Clinical Research UT | Bountiful | Utah | 84010 | Not yet recruiting |
| Alpine Research Association | Layton | Utah | 84041 | Recruiting |
| Wasatch Clinical Research, LLC | Salt Lake City | Utah | 84107 | Not yet recruiting |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | Not yet recruiting |
| Dominion Medical Associates | Richmond | Virginia | 23219 | Not yet recruiting |
| VA Medical Center_Salem | Salem | Virginia | 24153 | Not yet recruiting |
| Selma Medical Associates | Winchester | Virginia | 22601-3834 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 221 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07797335, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 31, 2026 · Synced Sep 1, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07797335 live on ClinicalTrials.gov.