Neurocomputational Training to Improve Reward Responsiveness in Veterans With Anhedonia

ClinicalTrials.gov ID: NCT07928310

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Anhedonia, a reduction in motivation and in the ability to feel positive emotions, is widespread among Veterans across a range of psychiatric disorders. This impairment is associated with poorer psychosocial functioning and is resistant to first-line medication and psychotherapy treatments. However, interventions to improve anhedonia are sorely lacking. Reward learning supports motivation to seek rewards, and this mechanism can be enhanced by engaging in reward exploration. Our preliminary findings suggest that this approach can help improve reward responsiveness and positive mood among depressed and anxious individuals. Thus, the proposed research will test the preliminary efficacy of a computerized reward learning training in improving reward sensitivity and reducing anhedonia in Veterans. This new intervention could offer a novel remotely accessible treatment and help enhance the efficacy of existing evidence-based treatments for depression and other psychiatric conditions in Veterans.

Study identification

NCT ID: NCT07928310
Recruitment status: Not yet recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: VA Office of Research and Development; Federal
Enrollment: 120 participants

Conditions and interventions

Conditions

Interventions

ReLIT (Reward Learning Intensive Training) Behavioral
ST (Sham Training) Behavioral

Behavioral

Eligibility (public fields only)

Age range: 18 Years to 65 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 1, 2027 (Estimated)
Primary completion: Dec 31, 2030 (Estimated)
Completion: Mar 31, 2031 (Estimated)
Last update posted: Nov 10, 2026

2027 – 2031

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
VA San Diego Healthcare System, San Diego, CA	San Diego	California	92161-0002	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07928310, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Nov 10, 2026 · Synced Nov 15, 2026