AMBITION 3: A Research Study Investigating How Well Zenagamtide at Higher Dose Levels Lowers Blood Sugar and Body Weight Compared to Semaglutide in People With Type 2 Diabetes Treated With Metformin, SGLT2i, or Both
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Official title
Efficacy and Safety of Zenagamtide s.c. Once Weekly Compared to Semaglutide s.c. Once Weekly at Higher Dose Levels in Participants With Type 2 Diabetes Inadequately Controlled on Metformin, SGLT2i, or Both (AMBITION 3)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have type 2 diabetes. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will get one of the following: Zenagamtide (the treatment being tested) or Semaglutide (an approved and commonly prescribed treatment used as comparator).
Study identification
- NCT ID
- NCT07931573
- Recruitment status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,200 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 10, 2026 (Estimated)
- Primary completion
- Jul 4, 2028 (Estimated)
- Completion
- Aug 8, 2028 (Estimated)
- Last update posted
- Nov 12, 2026
2026 – 2028
United States locations
- U.S. sites
- 55
- U.S. states
- 22
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rio Clinical Trials Arizona | Phoenix | Arizona | 85016 | — |
| Scripps Whittier Diabetes Inst | La Jolla | California | 92037 | — |
| Diabetes & Endocrine Specialists - La Mesa | La Mesa | California | 91942 | — |
| First Valley Med Grp Lancaster | Lancaster | California | 93534 | — |
| Los Angeles Institute for Metabolic Research | Los Angeles | California | 90015 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Desert Oasis Hlthcr Med Group | Palm Springs | California | 92262 | — |
| Linda Vista Health Care Ctr | San Diego | California | 92111 | — |
| Southern Cal Clinical Research | Santa Ana | California | 92701 | — |
| Encompass Clinical Research_Spring Valley | Spring Valley | California | 91978 | — |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | — |
| Chase Medical Research LLC | Waterbury | Connecticut | 06708 | — |
| Encore Medical Research LLC | Hollywood | Florida | 33024 | — |
| University of Florida Cardiology | Jacksonville | Florida | 32256 | — |
| My Preferred Research | Miami | Florida | 33155 | — |
| New Horizon Research Center | Miami | Florida | 33165 | — |
| GTL Med & Res Group | Miami | Florida | 33173 | — |
| Life Medical Research Group | Miami Gardens | Florida | 33014 | — |
| South Broward Research LLC | Miramar | Florida | 33027 | — |
| Adult Medicine of Lake County, Inc | Mt. Dora | Florida | 32757 | — |
| West Orange Endocrinology | Ocoee | Florida | 34761 | — |
| Florida Institute for Clinical research | Orlando | Florida | 32825 | — |
| True Blue Clinical Research | Tampa | Florida | 36607 | — |
| Encore Medical Research of Weston | Weston | Florida | 33331 | — |
| Solaris Clinical Research | Meridian | Idaho | 83646 | — |
| Clinical Invest Special_Gurnee | Gurnee | Illinois | 60031 | — |
| Cotton O'Neil Diab & Endo Ctr | Topeka | Kansas | 66606 | — |
| MedStar Health Research Institute | Olney | Maryland | 20832 | — |
| Endo And Metab Cons | Rockville | Maryland | 20852 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115 | — |
| Elite Clinical Research | Flint | Michigan | 48532 | — |
| StudyMetrix Research LLC | City of Saint Peters | Missouri | 63303 | — |
| Palm Research Center Inc-Vegas | Las Vegas | Nevada | 89148 | — |
| Southern NH Diabetes and Endo_Nashua | Nashua | New Hampshire | 03060 | — |
| AMC Community Endocrinology | Albany | New York | 12203 | — |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | — |
| PharmQuest Life Sciences LLC | Greensboro | North Carolina | 27408 | — |
| Monroe Biomedical Research, LLC | Monroe | North Carolina | 28112 | — |
| Accellacare | Wilmington | North Carolina | 28401 | — |
| Diab & Endo Assoc of Stark Co | Canton | Ohio | 44718 | — |
| DelRicht Research at Newton Family Medicine | Charleston | South Carolina | 29407 | — |
| Spartanburg Medical Research | Spartanburg | South Carolina | 29303 | — |
| South Dakota Urban Indian Health | Sioux Falls | South Dakota | 57104 | — |
| Holston Medical Group Pc | Bristol | Tennessee | 37620-7352 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Clinical Research Associates | Nashville | Tennessee | 37203 | — |
| Victorium Clinical Research | Houston | Texas | 77024 | — |
| Southwest Clinical Trials | Houston | Texas | 77074 | — |
| Medical Colleagues-Texas LLP | Katy | Texas | 77450 | — |
| Pinnacle Clinical Research | San Antonio | Texas | 78222 | — |
| NE Clin Res of San Antonio | San Antonio | Texas | 78233 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Texas Valley Clinical Research | Weslaco | Texas | 78596 | — |
| Diabetes & Endo Treatment Spec | Sandy City | Utah | 84093 | — |
| Rainier Clin Res Ctr Inc | Renton | Washington | 98057 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 175 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07931573, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 12, 2026 · Synced Nov 14, 2026
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