Condition Directory

ALS clinical trials

Directory of U.S. ClinicalTrials.gov public records for ALS. Browse ALS recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 21, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 21, 2026, 8:43 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

487

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How ALS studies are organized in the registry

Listings appear under both the abbreviation ALS and the full name “amyotrophic lateral sclerosis,” and some related records use “motor neuron disease.” The total volume is modest, so browsing the unfiltered list is practical; expanded-access records also appear in this condition and are labeled as such in the study-type field.

Terms that often appear in related listings

amyotrophic lateral sclerosis motor neuron disease SOD1 expanded access

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 109–120 of 487 matching trials for ALS.

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Local aggregate panels are unavailable or hidden for filtered views. The result list above identifies its data source.

Live official records

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Conditions: Amyotrophic Lateral Sclerosis
Interventions: Tofersen; Drug
Lead sponsor: Biogen; Industry
Eligibility: 18 Years and older
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2033
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Amyotrophic Lateral Sclerosis
Interventions: nL-TARD-001; Drug
Lead sponsor: n-Lorem Foundation; Other
Eligibility: 49 Years to 49 Years · Female only
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: New York, New York • Houston, Texas

Conditions: ALS, Amyotrophic Lateral Sclerosis, PALS
Interventions: CNM-Au8; Drug
Lead sponsor: Clene Nanomedicine; Industry
Eligibility: 18 Years and older
U.S. locations: 8
States / cities: Fort Lauderdale, Florida • Chicago, Illinois • Iowa City, Iowa + 4 more

Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: Structured Communicative Interaction, Unstructured communicative interaction; Behavioral
Lead sponsor: Penn State University; Other
Eligibility: 18 Years to 90 Years
Enrollment: 152 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: University Park, Pennsylvania

Conditions: Amyotrophic Lateral Sclerosis, Frontotemporal Dementia
Interventions: TPN-101, 400 mg/day, Placebo; Drug
Lead sponsor: Transposon Therapeutics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 10
States / cities: La Jolla, California • Orange, California • San Francisco, California + 5 more

Conditions: ALS
Interventions: Consume 20mg of istradefylline, Low Oxygen therapy, Placebo counterpart to the istradefylline drug, SHAM counterpart to low oxygen therapy.; Drug · Other
Lead sponsor: University of Florida; Other
Eligibility: 21 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 2
States / cities: Gainesville, Florida • Jacksonville, Florida

Conditions: Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Interventions: Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised, Amyotrophic Lateral Sclerosis Assessment Questionnaire-40; Other
Lead sponsor: TidalHealth, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Salisbury, Maryland

Conditions: ALS - Amyotrophic Lateral Sclerosis
Interventions: powered neck exoskeleton; Device
Lead sponsor: University of Utah; Other
Eligibility: Not listed
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Amyotrophic Lateral Sclerosis
Interventions: Not listed
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 10,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2037
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Amyotrophic Lateral Sclerosis
Interventions: Not listed
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2037
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Amyotrophic Lateral Sclerosis
Interventions: Not listed
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2037
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Amyotrophic Lateral Sclerosis
Interventions: Spinal Cord Associative Plasticity (SCAP), Upper extremity task-oriented exercise; Procedure
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: The Bronx, New York

About this ALS clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list ALS as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within ALS.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

ALS clinical trials

How ALS studies are organized in the registry

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Live official records

A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)

Personalized Antisense Oligonucleotide Therapy for A Single Participant With TARDBP ALS

Intermediate Expanded Access Protocol CNMAu8.EAP04

Examining Interactions Between PALS and Caregivers

A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD

Adenosine 2A Receptor Antagonism and AIH in ALS

Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth

Evaluation of a Structurally Suitable Neck Exoskeleton in Patients With Amyotrophic Lateral Sclerosis

Clinical Research in ALS Study

The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study

PRE-Symptomatic Studies in Amyotrophic Lateral Sclerosis

Spinal Cord Associative Plasticity for ALS

About this ALS clinical trials directory page