Condition Directory

ALS clinical trials

Directory of U.S. ClinicalTrials.gov public records for ALS. Browse ALS recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 21, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 21, 2026, 6:19 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

487

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How ALS studies are organized in the registry

Listings appear under both the abbreviation ALS and the full name “amyotrophic lateral sclerosis,” and some related records use “motor neuron disease.” The total volume is modest, so browsing the unfiltered list is practical; expanded-access records also appear in this condition and are labeled as such in the study-type field.

Terms that often appear in related listings

amyotrophic lateral sclerosis motor neuron disease SOD1 expanded access

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 265–276 of 487 matching trials for ALS.

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Live official records

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Conditions: Amyotrophic Lateral Sclerosis
Interventions: HealthPAL; Other
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Amyotrophic Lateral Sclerosis
Interventions: Respirometer, Handgrip Meter, Skulpt Chisel, ActigraphyMeter; Other
Lead sponsor: Jeremy Shefner; Other
Eligibility: 18 Years to 85 Years
Enrollment: 144 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Amyotrophic Lateral Sclerosis (ALS), Familial Amyotrophic Lateral Sclerosis, ALS With Frontotemporal Dementia (ALS/FTD), Lou Gehrig's Disease, Motor Neuron Disease (MND), Primary Lateral Sclerosis (PLS), Sporadic ALS (SALS)
Interventions: Genetic study of ALS families; Other
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 13,521 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1991 – 2023
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Amyotrophic Lateral Sclerosis, Progressive Muscular Atrophy, Motor Neuron Disease
Interventions: Not listed
Lead sponsor: Duke University; Other
Eligibility: Not listed
Enrollment: 25 participants
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Amyotrophic Lateral Sclerosis, ALS
Interventions: Placebo, Ravulizumab; Drug · Biological
Lead sponsor: Alexion Pharmaceuticals, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 382 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 34
States / cities: Phoenix, Arizona • Scottsdale, Arizona • Loma Linda, California + 27 more

Conditions: Amyotrophic Lateral Sclerosis, Frontal Temporal Dementia
Interventions: Memantine, Placebo (for Memantine); Drug
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years to 85 Years
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 13
States / cities: Phoenix, Arizona • Irvine, California • Jacksonville, Florida + 10 more

Conditions: ALS
Interventions: rTMS; Device
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 99 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: New York, New York

Conditions: ALS
Interventions: Mag Stim; Device
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: New York, New York

Conditions: Amyotrophic Lateral Sclerosis
Interventions: CES at rest, CES plus active hand or wrist movements; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 21 Years to 75 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Amyotrophic Lateral Sclerosis
Interventions: AMX0035; Drug
Lead sponsor: Amylyx Pharmaceuticals Inc.; Industry
Eligibility: 18 Years and older
U.S. locations: 20
States / cities: Los Angeles, California • Oakland, California • Fort Lauderdale, Florida + 14 more

Conditions: Amyotrophic Lateral Sclerosis, ALS, Lou Gehrig Disease, Lou Gehrig's Disease, Lou-Gehrigs Disease, Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Interventions: BHV-0223; Drug
Lead sponsor: Biohaven Pharmaceuticals, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 5
States / cities: Fort Lauderdale, Florida • Lincoln, Nebraska • Charlotte, North Carolina + 2 more

Conditions: Amyotrophic Lateral Sclerosis, Parkinson Disease, Dysphagia
Interventions: Videofluoroscopic Swallowing Examination, Tongue Strength Measurement; Diagnostic Test · Other
Lead sponsor: University Health Network, Toronto; Other
Eligibility: 18 Years to 90 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Gainesville, Florida

About this ALS clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list ALS as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within ALS.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

ALS clinical trials

How ALS studies are organized in the registry

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Live official records

Determining Feasibility and Acceptability of Sharing Video Recordings With Patients With ALS and Caregivers

ALS Testing Through Home-based Outcome Measures

Genetics of Familial and Sporadic ALS

Study of ALS Reversals 4: LifeTime Exposures

An Efficacy and Safety Study of Ravulizumab in ALS Participants

Therapy in Amyotrophic Lateral Sclerosis (TAME)

Non-invasive Brain Stimulation for the Treatment of Depression Symptoms in ALS

rTMS in Treatment of Spasticity

Cervical Electrical Stimulation for ALS

An Intermediate Size Expanded Access Protocol of AMX0035 for ALS

Open-label Study to Evaluate Safety, Tolerability and PK of BHV-0223 in ALS

Physiological Flow of Liquids Used in Dysphagia Management (Neuro)

About this ALS clinical trials directory page