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Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 25, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 25, 2026, 3:34 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials
5328
Shown on this page
12
Current sort
Recently updated
Condition scope
Depression
Additional filters apply within this condition.

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

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These controls apply only within Depression. Default order is Recently updated. Add location, sponsor, treatment, or recruitment status to narrow this condition page further.

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Showing 181–192 of 5,328 matching trials for Depression.
Live ClinicalTrials.gov results.
Local aggregate panels are unavailable or hidden for filtered views. The result list above identifies its data source.

Live official records

Open in full search
Conditions
Depression
Interventions
Cognitive Behavioral Faith Fellowship to Improve Thy Health (CB-FAITH)
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
3
States / cities
Madison, Wisconsin
Conditions
Depression
Interventions
Lung scan, Apremilast, 18F-PF-06445974
Radiation · Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 70 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
1
States / cities
Bethesda, Maryland
Recruiting Not applicable Interventional Accepts healthy volunteers

Geolocation Positional System (GPS) Experience

NCT05991713
Conditions
Emotions, Anhedonia, Depression
Interventions
Modifying Exploration
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 50 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Coral Gables, Florida
Conditions
Anxiety, Depression, Coping Skills, Emotional Problem
Interventions
Education, Reappraisal Coping, Distraction Coping, Relaxation Coping
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
9 Years to 12 Years
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Tempe, Arizona
Conditions
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 Infection
Interventions
PET Tracer, MRI Tracer, 3T PET/MRI
Drug · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Completed Not applicable Interventional Accepts healthy volunteers

BasketballRx: Game Changing Health

NCT07778433
Conditions
Pediatric Obesity, Pediatric Overweight, Anxiety, Depression Disorders, Childhood Obesity, Childhood Overweight, Mental Health, Adolescent Obesity
Interventions
BasketballRx
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
10 Years to 15 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
2
States / cities
Harrisburg, Pennsylvania
Conditions
Breast Cancer
Interventions
Single Counseling Session, American Cancer Society booklet
Behavioral · Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Conditions
Alzheimer Disease, Agitation,Psychomotor, Care Giving Burden, NPS, Aggression
Interventions
IGC-AD1-Active, IGC-AD1-Placebo
Drug
Lead sponsor
IGC Pharma, LLC
Industry
Eligibility
60 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
21
States / cities
Maitland, Florida • Melbourne, Florida • Miami, Florida + 15 more
Conditions
Depression - Major Depressive Disorder
Interventions
Passive Viewing Task, Interaction Task
Other
Lead sponsor
Binghamton University
Other
Eligibility
6 Months and older
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Binghamton, New York
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Neonatal Neurodevelopmental Outcomes

NCT07101757
Conditions
Food Insecurity, Depression, Anxiety, Stress
Interventions
Not listed
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Houston, Texas
Conditions
Intimate Partner Violence (IPV)
Interventions
RISE, Advocacy-based ECAU
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
3
States / cities
Boston, Massachusetts • Minneapolis, Minnesota • Philadelphia, Pennsylvania
Conditions
Depressive Symptoms, Emotional Depression, Depression, Parent Child Relationship, Parent-Child Relationship, Parent-Child Relations, Stress Disorder, Post Traumatic, PTSD, Parenting, Child Behavior, Emotional Regulation, Emotion Regulation
Interventions
Parenting-STAIR Modular (PSTAIR-M), Treatment as Usual (TAU)
Behavioral
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
243 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
4
States / cities
Colorado Springs, Colorado • Silver Spring, Maryland • Lawton, Oklahoma + 1 more

About this Depression clinical trials directory page

What this page lists
U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results
Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from
Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Related: all condition pages, browse by drug or therapy, browse by U.S. city, browse by sponsor, or open the full search for Depression.