Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 25, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 25, 2026, 2:54 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 169–180 of 5,328 matching trials for Depression.

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Conditions: Alcohol Use Disorder, Depression
Interventions: Lifestyle Physical Activity (LPA), Fitbit Only; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 176 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Head and Neck Cancer, Head and Neck Cancers, Depression
Interventions: IONA Mind app; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 22 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Depression in Adolescence
Interventions: Yoga-Based Intervention, group CBT; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 12 Years to 18 Years
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Boston, Massachusetts • Columbus, Ohio

Conditions: Depression, Epilepsy
Interventions: Vagal nerve stimulant; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Rochester, Minnesota

Conditions: Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Anxiety, Depression, Post Concussion Symptoms
Interventions: Hyperbaric Oxygen Therapy (HBOT); Drug
Lead sponsor: Summit Hyperbarics and Wellness; Other
Eligibility: 18 Years to 75 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Boise, Idaho

Conditions: Major Depressive Disorder
Interventions: Directional Deep Brain Stimulation; Device
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 22 Years to 70 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 2
States / cities: Dallas, Texas • Houston, Texas

Conditions: Depression
Interventions: Theta Burst Stimulation; Device
Lead sponsor: Erika Forbes; Other
Eligibility: 18 Years to 26 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Depression, Anxiety, Obsessive Compulsive Disorder (OCD)
Interventions: ATTN201 head-worn focused ultrasound; Device
Lead sponsor: Attune Neurosciences Inc; Industry
Eligibility: 22 Years to 80 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Traumatic Injury, Posttraumatic Stress Disorder, Depression, Social Determinants of Health
Interventions: CHW support; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Depressive Disorder, Major
Interventions: Seltorexant, Placebo; Drug
Lead sponsor: Janssen Research & Development, LLC; Industry
Eligibility: 18 Years to 74 Years
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 34
States / cities: Bryant, Arkansas • Bellflower, California • Glendale, California + 27 more

Conditions: Behavioral Symptoms, Suicide, Self-Injurious Behavior, Sensory System Agents, Analgesics, Peripheral Nervous System Agents, Physiological Effects of Drugs, Anesthetics, Dissociative, Anesthetics, General, Anesthetics, Central Nervous System Depressants, Excitatory Amino Acid Antagonists, Excitatory Amino Acid Agents, Neurotransmitter Agents, Molecular Mechanisms of Pharmacological Action, Ketamine, Depression, Unipolar, Depressive Symptoms, Treatment Resistant Depression, Major Depressive Disorder, Depression, Bipolar
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 120 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2030
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Depression, Suicide Risk
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 99 Years
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2028
U.S. locations: 1
States / cities: Bethesda, Maryland

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Testing a Lifestyle Physical Activity Intervention for Women With Depression in Alcohol Treatment

Mental Health App for Cancer Survivors Study

Teenthrive 2: Treatments for Improving Mood in Teens

Effect of Vagal Nerve Stimulation on Gastric Motor Functions

HBOT Effects on First Responders' Cognition and Well-Being

DBS for Depression

Treatment, Emotion, and Neuromodulation of Depression (TREND) Study

Focused Ultrasound for Behavioral Health

CHW-Enhanced Trauma Recovery

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

Natural History of Depression, Bipolar Disorder and Suicide Risk

Long-term Observation of Participants With Mood Disorders

About this Depression clinical trials directory page