Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 26, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 26, 2026, 4:46 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 337–348 of 5,328 matching trials for Depression.

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Live official records

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Conditions: Anxiety Disorders, Stress Disorders, Post-Traumatic, Pregnancy, High Risk, Depressive Disorder, Major, Pregnancy Complications, ADHD - Attention Deficit Disorder With Hyperactivity
Interventions: Collaborative Mental Health Care Program (CMHCP); Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 100 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Depression - Major Depressive Disorder, Catatonia
Interventions: Electroconvulsive Therapy; Procedure
Lead sponsor: University of Pennsylvania; Other
Eligibility: Not listed
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Major Depression, Major Depression Disorders
Interventions: Transcranial Direct Current Stimulation (tDCS); Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Depressive Symptoms, Depression, Alzheimer Disease, Mild Cognitive Impairment
Interventions: Psilocybin; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Chronic Low-back Pain, Depression
Interventions: Psilocybin, Methylphenidate; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Major Depressive Disorder
Interventions: BMS-986511, Placebo; Drug
Lead sponsor: Bristol-Myers Squibb; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 21
States / cities: Phoenix, Arizona • Little Rock, Arkansas • Rogers, Arkansas + 18 more

Conditions: Post Stroke Depression
Interventions: Zuranolone; Drug
Lead sponsor: Duke University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Parkinson Disease, Depression, Anxiety
Interventions: Psilocybin therapy; Drug
Lead sponsor: Joshua Woolley, MD, PhD; Other
Eligibility: 40 Years to 75 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Depression in Adolescence, Obesity & Overweight, Cognitive-behavioral Therapy, Mobile Health Technology (mHealth), Health Behavior
Interventions: Cognitive-behavioral therapy (CBT), Digital app; Behavioral
Lead sponsor: Colorado State University; Other
Eligibility: 12 Years to 17 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Major Depressive Disorder, Bipolar Disorder, Healthy
Interventions: [18F]FPEB, [11C]APP311; Radiation
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 79 participants
Timeline: 2017 – 2024
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Stimulant Use, Human Immunodeficiency Virus (HIV), Depression
Interventions: ARTEMIS, Contingency management for Antiretroviral (ARV) adherence; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 59 Years
Enrollment: 189 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Depression Disorders, ADHD, Substance Abuse, Social Stigma, Help-Seeking Behavior, Caregiver Burden
Interventions: Brief video; Other
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 25 Years to 50 Years
Enrollment: 1,600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: New York, New York

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

MOCHA: Embedded Inpatient Mental Health Care for High-Risk Perinatal Patients

Optimizing Stimulation Parameters for Electroconvulsive Therapy

Accelerated High-Dose tDCS for Depression

Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

Psilocybin in Chronic Low Back Pain and Depression

A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder

Allopregnanolone (Zuranolone) in Post-stroke Depression

Psilocybin Therapy for Depression and Anxiety in Parkinson's Disease

Digitally Enhanced Cognitive-Behavioral Therapy

Imaging mGluR5 and Synaptic Density in Psychiatric Disorders

Project neuroARTEMIS

Brief Intervention Addressing Stigma Among Parents of Children With Mental Health Problems

About this Depression clinical trials directory page