Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 28, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 28, 2026, 3:24 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 445–456 of 5,331 matching trials for Depression.

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Live official records

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Conditions: Alcohol and Substance-Related Mental Disorders
Interventions: SBIRT, Treatment as usual; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 15 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Chronic Pain, Depression
Interventions: Mindfulness-based cognitive therapy; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 50 Years to 120 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Posttraumatic Stress Disorder, Major Depressive Disorder
Interventions: Positive Processes and Transition to Health, Progressive Muscle Relaxation; Behavioral
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 135 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 3
States / cities: Newark, Delaware • Cleveland, Ohio • Seattle, Washington

Conditions: Major Depressive Disorder, Depression in Adolescence, Depression, Major Depressive Episode
Interventions: MagPro X100 edition (MagVenture, Skovlunde, Denmark); Device
Lead sponsor: University of Texas at Austin; Other
Eligibility: 13 Years to 20 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Concussion, Depression
Interventions: ONE-D TMS protocol and d-cycloserine (125 mg); Device
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Ocala, Florida

Conditions: Depression
Interventions: 11C-MCI, 11CPS13; Drug
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2030
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Obesity, Depression
Interventions: vCare Intervention (6-month active treatment followed by 6-month maintenance), vCare Intervention (active treatment after 6 months); Behavioral
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 50 Years to 74 Years
Enrollment: 440 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Chicago, Illinois • St Louis, Missouri

Conditions: Depression, Anxiety, Suicide, Drug Use
Interventions: eHealth Familias Unidas Mental Health; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 12 Years to 16 Years
Enrollment: 468 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2028
U.S. locations: 17
States / cities: Miami, Florida

Conditions: Major Depressive Disorder
Interventions: SP-624, Placebo; Drug
Lead sponsor: Sirtsei Pharmaceuticals, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 497 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 50
States / cities: Phoenix, Arizona • Tucson, Arizona • Bryant, Arkansas + 46 more

Conditions: Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation
Interventions: Closed-loop tACS, Sham Comparator; Device
Lead sponsor: Pulvinar Neuro, LLC; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Bipolar Depression
Interventions: Ketogenic Diet; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 50 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Epilepsy, Depressive Symptoms
Interventions: Ketamine; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Atlanta, Georgia

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia

Mindfulness-based Cognitive Therapy for the Chronic Pain-depression Co-morbidity Among Older Black Adults in the Community; The Quiet Focus Open Pilot

Positive Processes and Transition to Health (PATH)

Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents

Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion

PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older

Mental Health in Primary Care

A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder

Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder

Ketogenic Intervention for Bipolar Depression

Electrophysiologic Mechanisms of Ketamine Antidepressant Response

About this Depression clinical trials directory page