Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 28, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 28, 2026, 2:05 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 601–612 of 5,333 matching trials for Depression.

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Conditions: Childhood Depression
Interventions: Family-Focused Treatment for Childhood-Depression (FFT-CD); Behavioral
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 7 Years to 12 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 2
States / cities: Boston, Massachusetts • Charlestown, Massachusetts

Conditions: Depression
Interventions: Low UPF Meals (Study Provided), Low UPF Nutritional Guidance, Low UPF Snacks (Study Provided); Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Schizoaffective Disorders, Bipolar Disorder With Psychotic Features, Schizophrenia Disorders, Major Depressive Disorder With Psychotic Features, Psychosis NOS
Interventions: Transition Care Team; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 40 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: Chicago, Illinois • Harvey, Illinois

Conditions: Migraine, Depressive Symptoms
Interventions: MBCT-Telephone, MBCT-Video, Enhanced Usual Care (EUC); Behavioral
Lead sponsor: Amanda Shallcross; Other
Eligibility: 18 Years and older
Enrollment: 145 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 3
States / cities: The Bronx, New York • Winston-Salem, North Carolina • Cleveland, Ohio

Conditions: Depression
Interventions: Cognitive Control Training, Peripheral Vision Task; Other
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 18 Years to 65 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Depression, Posttraumatic Stress Disorder, Pregnancy Related, Medication Adherence
Interventions: Brief CBT-Based Intervention, Enhanced Treatment as Usual; Behavioral · Other
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 15 Years and older · Female only
Enrollment: 118 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Major Depressive Disorder
Interventions: NBI-1070770, Placebo; Drug
Lead sponsor: Neurocrine Biosciences; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 13
States / cities: Little Rock, Arkansas • Rogers, Arkansas • Lemon Grove, California + 10 more

Conditions: Depression
Interventions: Family Focused Treatment (FFT), Individual Treatment (IP); Behavioral
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 7 Years to 13 Years
Enrollment: 134 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 2
States / cities: Los Angeles, California • Boston, Massachusetts

Conditions: Depressive Disorder, Anxiety Disorders
Interventions: Group Behavioral Activation Therapy (GBAT); Behavioral
Lead sponsor: Rutgers University; Other
Eligibility: 11 Years to 15 Years
Enrollment: 895 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Piscataway, New Jersey

Conditions: Anxiety Disorders, Depression
Interventions: Coping Cat/CAT Project, Primary and Secondary Coping Enhancement Therapy; Behavioral
Lead sponsor: Rutgers University; Other
Eligibility: 7 Years to 17 Years
Enrollment: 247 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2020
U.S. locations: 1
States / cities: Piscataway, New Jersey

Conditions: Depression
Interventions: Music therapy; Other
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 7 Years to 15 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Chronic Pain, Depression
Interventions: Repetitive Transcranial Magnetic Stimulation, Acceptance and Commitment Therapy; Device · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: San Diego, California

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

Filter and sort this condition

Live official records

Neural Mechanisms of Family-Focused Treatment for Youth Depression

You Are What You Eat: Food as a Risk Factor and a Treatment for Depression

Transition Care for FEP

Treatment for Migraine and Mood

Cognitive Control Training for Depression

Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

A Study to Evaluate the Efficacy and Safety of NBI-1070770 in Adults With Major Depressive Disorder

Systems of Support Study for Childhood Depression

Transdiagnostic Behavioral Activation Therapy for Youth Anxiety and Depression

Process and Outcomes in CBT for Anxious and Depressed Youth

Assessment of Music Experiences in Navigating Depression Part 2

Repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy

About this Depression clinical trials directory page