Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 28, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 28, 2026, 3:03 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 613–624 of 5,333 matching trials for Depression.

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Live official records

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Conditions: Family Caregivers, Dementia, Self-management, Depression, Internet-based Intervention
Interventions: Building Better Caregivers workshop; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 109 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: San Francisco, California • Cooperstown, New York

Conditions: Stroke, Acute Stroke
Interventions: Not listed
Lead sponsor: Alexander Kusnecov, Ph.D.; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression, Depression, Major Depressive Episode
Interventions: Lithium; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 60 Years
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Depression
Interventions: Transcranial Magnetic Stimulation Sham; Device
Lead sponsor: University of California, Davis; Other
Eligibility: 15 Years to 25 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Major Depressive Disorder, Unipolar, Non-psychotic Major Depressive Disorder
Interventions: Not listed
Lead sponsor: Mayo Clinic; Other
Eligibility: 20 Years to 62 Years
Enrollment: 40 participants
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Cardiac Arrest, Anxiety Depression, Family Support
Interventions: Education Intervention; Other
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 0 Days to 17 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Autism Spectrum Disorder
Interventions: MAGSTIM Rapid2 TMS system; Device
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Major Depressive Disorder, Obsessive-Compulsive Disorder, Schizophrenia, Generalized Anxiety Disorder, Mood Disorders, Psychiatric Disorder, Mental Disorder, Depression, Anxiety
Interventions: Transcranial magnetic stimulation; Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 2
States / cities: Sunnyvale, California • Boston, Massachusetts

Conditions: Respiratory Complications, Opioid Induced Respiratory Depression, Postoperative Respiratory Complications
Interventions: Respiratory volume monitoring; Diagnostic Test
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Depression and/or Anxiety in the Mild-to-moderate Range, Stress (Psychology), Chronic Medical Illness
Interventions: SanaMente; Behavioral
Lead sponsor: University of Colorado, Boulder; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Carbondale, Colorado

Conditions: Treatment Resistant Depression, Undergoing Deep Brain Stimulation (DBS) Surgery
Interventions: Abbott Laboratories Infinity™ implantable deep brain stimulation system; Device
Lead sponsor: Nader Pouratian; Other
Eligibility: 21 Years to 70 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Body Image Disturbance, Disordered Eating Behaviors, Eating Disorder Prevention
Interventions: Wysa Digital Chatbot Program; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 13 Years to 19 Years
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD

Inflammation and Post-Stroke Depression

Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

Cognition and Behavior With Sham Accelerated TMS

Multi-Omic, Clinomic and Digitomic Attributes of Major Depression for Integrative Analytics

Removing Surrogates Uncertainty to Reduce Fear and Anxiety After Cardiac Events - Kids

Transcranial Magnetic Stimulation (TMS) to Treat Depression in Autism Spectrum Disorder

Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

Timing of Opioid Administration and Postoperative Respiratory Depression.

SanaMente: A Peer-Led Program to Reduce Health Disparities in Rural Latino/a Communities

Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression

Adolescent Chatbot

About this Depression clinical trials directory page