Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 29, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 28, 2026, 8:06 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 661–672 of 5,333 matching trials for Depression.

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Live official records

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Conditions: Depression
Interventions: Gamified Attention Bias Modification, Gamified Placebo Training; Device
Lead sponsor: Christopher G. Beevers; Other
Eligibility: 18 Years to 45 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Major Depressive Disorder
Interventions: NMRA-335140, Placebo; Drug
Lead sponsor: Neumora Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 422 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 34
States / cities: Cerritos, California • Irvine, California • Long Beach, California + 27 more

Conditions: Cystic Fibrosis (CF)
Interventions: Not listed
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 18 Months to 11 Years
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 13
States / cities: Orange, California • Aurora, Colorado • Hollywood, Florida + 10 more

Conditions: Knee Osteoarthritis, Depression
Interventions: repetetive transcranial magnetic stimulation; Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 50 Years to 95 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Depression Disorders, Depression - Major Depressive Disorder, Depression Disorder, Depression Chronic, Depression, Depression in Adults
Interventions: heated yoga, sauna, mindfulness app; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Depression Mild, Depression, Depression Moderate
Interventions: Matter Neuroscience App, Stock Photos, No Home Training, Personal Photos, Home Training; Device · Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Stanford, California

Conditions: Depression, Perinatal Depression
Interventions: Perinatal depression online cognitive-behavioral therapy course, Clinical care (psychotherapy sessions); Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older · Female only
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Cannabis Use Disorder, Major Depressive Disorder (MDD)
Interventions: Pregnenolone; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 50 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Dallas, Texas • Richardson, Texas

Conditions: Major Depressive Disorder
Interventions: NMRA-335140, Placebo; Drug
Lead sponsor: Neumora Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 430 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 57
States / cities: Encino, California • Garden Grove, California • Los Alamitos, California + 42 more

Conditions: Perinatal Depression
Interventions: Mamma Mia, Mamma Mia Plus; Device · Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 1,757 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Depression
Interventions: self-monitoring; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 64 Years
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Hines, Illinois

Conditions: Major Depressive Disorder, Treatment Resistant Depression, Bipolar Depression
Interventions: Ketamine; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Rochester, Minnesota

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Evaluation of a Therapeutic Mobile App for Depression

Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression

Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression

fMRI Neurofeedback With Matter Neuroscience App

Health And Response: Digital Markers for Outcomes in Perinatal Depression Treatment Study

Pregnenolone for Cannabis Use Disorder and Depression

Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

"Mamma Mia" for Perinatal Health and Wellness

An eHealth Intervention to Increase Depression Treatment Initiation and Adherence Among Veterans Referred for Mental Health Services

Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:

About this Depression clinical trials directory page