Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 29, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 28, 2026, 10:44 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 697–708 of 5,333 matching trials for Depression.

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Local aggregate panels are unavailable or hidden for filtered views. The result list above identifies its data source.

Live official records

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Conditions: Mental Health Issue, Breast Cancer
Interventions: Digital Micro-Interventions; Behavioral
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older · Female only
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Cancer in Remission (Any Type or Stage), Depression, Anxiety
Interventions: Repetitive Transcranial Magnetic Stimulation (rTMS); Device
Lead sponsor: Northwestern University; Other
Eligibility: 22 Years to 80 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2023
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Postpartum Depression, Mood Disorders, Anxiety Disorders, Postpartum Anxiety
Interventions: Whole-Body Hyperthermia, fMRI; Other · Diagnostic Test
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2028 – 2032
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder, Social Anxiety Disorder
Interventions: CBT, ST; Behavioral
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 18 Years to 65 Years
Enrollment: 203 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Suicidal Behavior, Suicidal Ideation, Negative Urgency, Cortical Inhibition, Depression
Interventions: Single-/paired-pulse transcranial magnetic stimulation; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 13 Years to 21 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Major Depression, Sleep
Interventions: TMS; Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Stanford, California

Conditions: Major Depressive Disorder
Interventions: Deep Brain Stimulation; Device
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2024
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Epilepsy, SUDEP
Interventions: 6% Carbon dioxide/50% oxygen/balance nitrogen mixture; Other
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 99 Years
Enrollment: 335 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2029
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Adjunctive Treatment of Major Depressive Disorder (MDD)
Interventions: CLE-100, Placebo; Drug
Lead sponsor: Clexio Biosciences Ltd.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 23
States / cities: La Jolla, California • Lafayette, California • Upland, California + 20 more

Conditions: Parents, Children With Disabilities, Stress, Depression
Interventions: ACT Together; Behavioral
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Depression, Mental Disorder in Adolescence
Interventions: Competent Adulthood Transition with Cognitive-Behavioral, Humanistic and Interpersonal Training; Behavioral
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 13 Years to 18 Years
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 6
States / cities: Chicago, Illinois • Glenview, Illinois • Park Ridge, Illinois + 1 more

Conditions: Unipolar Depression, Bipolar Depression
Interventions: Vortioxetine, Cariprazine (Augmentation Phase); Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Rochester, Minnesota

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

A Pre-post Pilot of a Smartphone Intervention

Repetitive Transcranial Magnetic Stimulation in Cancer Patients With Depression and Anxiety

Whole-Body Hyperthermia for Mood and Anxiety Disorders

Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy Response

Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior

Sleep TMS for Depression

Deep Brain Stimulation for Treatment Resistant Depression

Carbon Dioxide (CO2) Chemosensitivity and SUDEP

A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder

ACT Together: Implementing a Web-Based Program With Brief Coaching for Parents of Children With Disabilities in Pediatric Outpatient Clinics

The PATHway Study: Primary Care Based Depression Prevention in Adolescents

RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)

About this Depression clinical trials directory page