Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 29, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 28, 2026, 11:21 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 709–720 of 5,333 matching trials for Depression.

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Live official records

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Conditions: Major Depressive Disorder, Schizo Affective Disorder, Schizophrenia, Bipolar Disorder
Interventions: Behavior Activation; Behavioral
Lead sponsor: Temple University; Other
Eligibility: 18 Years and older
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Healthy Volunteers
Interventions: Propofol - Emergence-from-LOR Protocol, Propofol - Light Sedation Protocol; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Stanford, California

Conditions: Depression - Major Depressive Disorder, Anxiety, PTSD - Post Traumatic Stress Disorder, Insomnia, Alcohol Use Disorder (AUD), Suicide Ideation
Interventions: Deaf CBT-TS; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Major Depressive Disorder, Treatment Resistant Depression
Interventions: Medtronic Summit RC+S DBS system; Device
Lead sponsor: Helen Mayberg, MD; Other
Eligibility: 25 Years to 70 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2030
U.S. locations: 1
States / cities: New York, New York

Conditions: Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury, Treatment, Sleep Health, Depression, Anxiety
Interventions: Sleep Intervention; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 10 Years to 19 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Hoarding Disorder, Hoarding, Depression
Interventions: iTBS; Device
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 70 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Postpartum Depression (PPD), Self-Efficacy, Parental Anxiety, Engagement, Patient, Usability, Length of Stay
Interventions: VoiceLove mobile phone application; Device
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Posttraumatic Stress Disorder, Major Depressive Disorder
Interventions: LDAEP, Placebo, sertraline; Diagnostic Test · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 2
States / cities: Boston, Massachusetts • Charleston, South Carolina

Conditions: Schizophrenia, Bipolar Disorder, Healthy, Psychosis, Schizophreniform Disorders, Schizo Affective Disorder, Major Depression With Psychotic Features
Interventions: Placebo and fMRI, Lorazepam and fMRI; Other · Drug
Lead sponsor: University of Michigan; Other
Eligibility: 16 Years to 60 Years
Enrollment: 143 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Depressive Disorder, Major
Interventions: Active neurofeedback, Sham neurofeedback; Behavioral
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 35 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Pain
Interventions: Virtual Reality; Other
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 8 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Myofascial Pain, Myalgia
Interventions: Brief Behavioral Therapy for Insomnia, BBTI, Physical Self-Regulation, PSR; Behavioral
Lead sponsor: Ian Boggero, PhD; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Lexington, Kentucky

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Getting Out of the House: Using Behavioral Activation to Increase Community Participation

Induction of Dreaming With EEG and Anesthesia in Healthy Adults

Deaf CBT-TS to Reduce Suicide Risk

DBS for TRD With the Medtronic Summit RC+S

Multidimensional Sleep Health Intervention to Optimize Concussion Recovery

Neuromodulation for Comorbid Hoarding Disorder and Depression

NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)

Predicting SSRI Efficacy in Veterans With PTSD

Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis

Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression

Virtual Reality for Pain Management in Burn Patients

BBTI vs PSR in Musculoskeletal Orofacial Pain Adults

About this Depression clinical trials directory page