Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 29, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 29, 2026, 12:33 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 733–744 of 5,333 matching trials for Depression.

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Live official records

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Conditions: Major Depressive Disorder
Interventions: Siemens 7T MRI, Sham Neurofeedback; Device
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking, Depression
Interventions: Smoking Cessation Treatment, Nicotine Replacement Therapy, CBASP; Behavioral · Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 16 Years and older
Enrollment: 91 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Major Depressive Disorder
Interventions: Icalcaprant, Placebo for Icalcaprant; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 195 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 33
States / cities: Dothan, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 27 more

Conditions: Crohn Disease, Ulcerative Colitis (UC)
Interventions: Psychologist-administered Cognitive Behavioral Therapy, Self-Administered Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Anxiety Depression
Interventions: EASE app, INSIGHT (Control) App; Other
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 822 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 2
States / cities: Oklahoma City, Oklahoma • Houston, Texas

Conditions: Psychiatric Disorder, Memory Disorders
Interventions: Not listed
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Substance-Related Disorders, Depressive Disorder, Anxiety Disorder
Interventions: OutPatient Treatment for Adolescents (OPT-A), Treatment As Usual; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 10 Years to 17 Years
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Hematopoietic Stem Cell Transplant
Interventions: Ayo wearable; Device
Lead sponsor: St. Jude Children's Research Hospital; Other
Eligibility: 8 Years to 18 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Anxiety Disorders, Psychotic Disorders, Depressive Disorder, Psychosocial Functioning
Interventions: Resilience Training for Teens; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 14 Years to 19 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Bipolar Disorder, Non-Adherence, Medication, Hypertension, Major Depressive Disorder
Interventions: iTAB-CV, Self-Monitoring; Behavioral
Lead sponsor: Case Western Reserve University; Other
Eligibility: 21 Years to 80 Years
Enrollment: 176 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Psychopathology, Child Mental Health, Anxiety Disorders, Mental Disorders, Inflamation, Poverty
Interventions: Psychological fMRI task; Other
Lead sponsor: Northwestern University; Other
Eligibility: 10 Years to 18 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Evanston, Illinois

Conditions: Depressive Symptoms
Interventions: Video, Active game, Neutral game; Behavioral
Lead sponsor: Bard College; Other
Eligibility: 18 Years and older
Enrollment: 350 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Annandale-on-Hudson, New York

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Network Neurofeedback Using 7-Tesla MRI to Reduce Rumination Levels in Depression

Smoking Cessation for Depressed Smokers

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

Use of Psychologist-administered Cognitive Behavioral Therapy (CBT) or Self-administered CBT for the Treatment of Anxiety and/or Depression in Inflammatory Bowel Disease (IBD)

Mobile Health and COVID-19

Neural Correlates of Psychiatric Disorders

Research on Outpatient Adolescent Treatment for Comorbid Substance Use and Internalizing Disorders

Light Therapy to Treat Depression in Pediatric Stem Cell Therapy Recipients

Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

Using mHealth to Improve Adherence and Reduce Blood Pressure in Individuals With Hypertension and Mood Disorders

Experimental Evidence of the Impact of Parental Income on Child Mental Health and Neuroimmune Function

Guided Feedback in an Online Game Impacts Decision Making

About this Depression clinical trials directory page